Impact of EGFR genetic variants on glioma risk and patient outcome

Bibliographic Details
Main Author: Costa, Bruno Marques
Publication Date: 2011
Other Authors: Pereira, Marta Viana, Fernandes, Ricardo, Costa, S., Linhares, Paulo, Vaz, Rui, Pinheiro, Céline, Lima, Jorge, Soares, Paula, Silva, Ana, Pardal, Fernando, Amorim, Júlia, Nabiço, Rui, Almeida, Rui, Alegria, Carlos, Pires, Manuel Melo, Pinheiro, Célia, Carvalho, Ernesto, Oliveira, P., Lopes, José M., Reis, R. M.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/1822/16679
Summary: B.M. Costa and M. Viana-Pereira contributed equally to this work; The authors thank the Immunochemotherapy Department of Hospital S. Marcos, and Clinica Laboratorial Dr. Edgar Botelho Moniz, S. Tirso, Portugal, for their helpful assistance in the management of controls
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spelling Impact of EGFR genetic variants on glioma risk and patient outcomeEpidermal growth factor receptorGliomaEpidemiologyGlioblastomaAstrocytomaOligodendrogliomaSingle-nucleotide polymorphismScience & TechnologyB.M. Costa and M. Viana-Pereira contributed equally to this work; The authors thank the Immunochemotherapy Department of Hospital S. Marcos, and Clinica Laboratorial Dr. Edgar Botelho Moniz, S. Tirso, Portugal, for their helpful assistance in the management of controlsBACKGROUND: The epidermal growth factor receptor (EGFR) regulates important cellular processes and is frequently implicated in human tumors. Three EGFR polymorphisms have been described as having a transcriptional regulatory function: two single-nucleotide polymorphisms in the essential promoter region, -216G/T and -191C/A, and a polymorphic (CA)(n) microsatellite sequence in intron 1. We aimed to elucidate the roles of these EGFR polymorphisms in glioma susceptibility and prognosis. METHODS: We conducted a case-control study with 196 patients with glioma and 168 cancer-free controls. Unconditional multivariate logistic regression models were used to calculate ORs and 95% confidence intervals. A Cox regression model was used to evaluate associations with patient survival. False-positive report probabilities were also assessed. RESULTS: None of the EGFR -216G/T variants was significantly associated with glioma risk. The -191C/A genotype was associated with higher risk for glioma when the (CA)(n) alleles were classified as short for ≤16 or ≤17 repeats. Independently of the (CA)(n) repeat cutoff point used, shorter (CA)(n) repeat variants were significantly associated with increased risk for glioma, particularly glioblastoma and oligodendroglioma. In all tested models with different (CA)(n) cutoff points, only -191C/A genotype was consistently associated with improved survival of patients with glioblastoma. CONCLUSIONS: Our findings implicate EGFR -191C/A and the (CA)(n) repeat polymorphisms as risk factors for gliomas, and suggest -191C/A as a prognostic marker in glioblastoma. Impact: Our data support a role of these EGFR polymorphisms in determining glioma susceptibility, with potential relevance for molecularly based stratification of patients with glioblastoma for individualized therapies.Schering-Plough Farma, PortugalFundação para a Ciência e a Tecnologia (FCT) - SFRH/BPD/33612/2009; SFRH/BD/29145/2006American Association for Cancer ResearchUniversidade do MinhoCosta, Bruno MarquesPereira, Marta VianaFernandes, RicardoCosta, S.Linhares, PauloVaz, RuiPinheiro, CélineLima, JorgeSoares, PaulaSilva, AnaPardal, FernandoAmorim, JúliaNabiço, RuiAlmeida, RuiAlegria, CarlosPires, Manuel MeloPinheiro, CéliaCarvalho, ErnestoOliveira, P.Lopes, José M.Reis, R. M.2011-122011-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/16679eng1055-996510.1158/1055-9965.EPI-11-034021960689http://cebp.aacrjournals.org/lookup/doi/10.1158/1055-9965.EPI-11-0340info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-11T04:22:55Zoai:repositorium.sdum.uminho.pt:1822/16679Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T14:46:57.288002Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Impact of EGFR genetic variants on glioma risk and patient outcome
title Impact of EGFR genetic variants on glioma risk and patient outcome
spellingShingle Impact of EGFR genetic variants on glioma risk and patient outcome
Costa, Bruno Marques
Epidermal growth factor receptor
Glioma
Epidemiology
Glioblastoma
Astrocytoma
Oligodendroglioma
Single-nucleotide polymorphism
Science & Technology
title_short Impact of EGFR genetic variants on glioma risk and patient outcome
title_full Impact of EGFR genetic variants on glioma risk and patient outcome
title_fullStr Impact of EGFR genetic variants on glioma risk and patient outcome
title_full_unstemmed Impact of EGFR genetic variants on glioma risk and patient outcome
title_sort Impact of EGFR genetic variants on glioma risk and patient outcome
author Costa, Bruno Marques
author_facet Costa, Bruno Marques
Pereira, Marta Viana
Fernandes, Ricardo
Costa, S.
Linhares, Paulo
Vaz, Rui
Pinheiro, Céline
Lima, Jorge
Soares, Paula
Silva, Ana
Pardal, Fernando
Amorim, Júlia
Nabiço, Rui
Almeida, Rui
Alegria, Carlos
Pires, Manuel Melo
Pinheiro, Célia
Carvalho, Ernesto
Oliveira, P.
Lopes, José M.
Reis, R. M.
author_role author
author2 Pereira, Marta Viana
Fernandes, Ricardo
Costa, S.
Linhares, Paulo
Vaz, Rui
Pinheiro, Céline
Lima, Jorge
Soares, Paula
Silva, Ana
Pardal, Fernando
Amorim, Júlia
Nabiço, Rui
Almeida, Rui
Alegria, Carlos
Pires, Manuel Melo
Pinheiro, Célia
Carvalho, Ernesto
Oliveira, P.
Lopes, José M.
Reis, R. M.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Costa, Bruno Marques
Pereira, Marta Viana
Fernandes, Ricardo
Costa, S.
Linhares, Paulo
Vaz, Rui
Pinheiro, Céline
Lima, Jorge
Soares, Paula
Silva, Ana
Pardal, Fernando
Amorim, Júlia
Nabiço, Rui
Almeida, Rui
Alegria, Carlos
Pires, Manuel Melo
Pinheiro, Célia
Carvalho, Ernesto
Oliveira, P.
Lopes, José M.
Reis, R. M.
dc.subject.por.fl_str_mv Epidermal growth factor receptor
Glioma
Epidemiology
Glioblastoma
Astrocytoma
Oligodendroglioma
Single-nucleotide polymorphism
Science & Technology
topic Epidermal growth factor receptor
Glioma
Epidemiology
Glioblastoma
Astrocytoma
Oligodendroglioma
Single-nucleotide polymorphism
Science & Technology
description B.M. Costa and M. Viana-Pereira contributed equally to this work; The authors thank the Immunochemotherapy Department of Hospital S. Marcos, and Clinica Laboratorial Dr. Edgar Botelho Moniz, S. Tirso, Portugal, for their helpful assistance in the management of controls
publishDate 2011
dc.date.none.fl_str_mv 2011-12
2011-12-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/16679
url http://hdl.handle.net/1822/16679
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1055-9965
10.1158/1055-9965.EPI-11-0340
21960689
http://cebp.aacrjournals.org/lookup/doi/10.1158/1055-9965.EPI-11-0340
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Association for Cancer Research
publisher.none.fl_str_mv American Association for Cancer Research
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833594881879048192

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