Anatomopathological and Immunohistochemical Profile of Gliomas of Patients in the Region of Maringá-PR

Detalhes bibliográficos
Autor(a) principal: Valadares, Adriana Domingues
Data de Publicação: 2021
Outros Autores: Souza-Kaneshima, Alice Maria, Kaneshima, Edilson Nobuyushi, Fernandes, Igor Lima, Jordão, Igor Passareli, Souza, Paola da Costa, Maftoum, Tarik Radi Campos
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Revista Brasileira de Cancerologia (Online)
DOI: 10.32635/2176-9745.RBC.2021v67n3.1287
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/1287
Resumo: Introduction: Gliomas represent 80% of the central nervous system tumors. World Health Organization (WHO) has added, in 2016, molecular features to the classification of gliomas. The pathophysiology and risk factors of these tumors are not yet fully understood. Objective: Perform a retrospective analysis of immunohistochemical and anatomopathological reports of gliomas. Method: Cross-sectional, retrospective and descriptive study carried out from anatomopathological and immunohistochemical exams made between January 2014 and December 2018 in a pathological anatomy laboratory in the city of Maringa-PR. Of the 234 reports related to the term glioma, 204 were selected for this study. Results: Astrocytic, ependymal and oligodendroglial tumors were found, with astrocytomas accounting for the majority (86.8% of the cases found). Mean age at diagnosis was 51.8 years and the prevalence was higher in men. Furthermore, immunohistochemically detectable mutations were analyzed, such as p53 (mutated in 66.7% of those tested), isocitrate dehydrogenase (IDH) (28.6% mutated), X-linked alpha-thalassemia mental retardation (ATRX) (21.0%) and diagnostic markers such as positive epithelial membrane antigen (EMA) in all analyzed ependymomas. Conclusion: The necessity of further researches on gliomas is undeniable , both epidemiologically considering the new classification and within the clinical and pathophysiological scope in order to improve the understanding of the pathology and the treatment for the patients.
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spelling Anatomopathological and Immunohistochemical Profile of Gliomas of Patients in the Region of Maringá-PRPerfil Anatomopatológico e Inmunohistoquímico de Gliomas en Pacientes la Región de Maringá-PRPerfil Anatomopatológico e Imuno-histoquímico de Gliomas de Pacientes da Região de Maringá-PRGliomaGlioblastomaAstrocitomaImuno-HistoquímicaEpidemiologia MolecularGliomaGlioblastomaAstrocytomaImmunohistochemistryMolecular EpidemiologyGliomaGlioblastomaAstrocitomaInmunohistoquímicaEpidemiología MolecularIntroduction: Gliomas represent 80% of the central nervous system tumors. World Health Organization (WHO) has added, in 2016, molecular features to the classification of gliomas. The pathophysiology and risk factors of these tumors are not yet fully understood. Objective: Perform a retrospective analysis of immunohistochemical and anatomopathological reports of gliomas. Method: Cross-sectional, retrospective and descriptive study carried out from anatomopathological and immunohistochemical exams made between January 2014 and December 2018 in a pathological anatomy laboratory in the city of Maringa-PR. Of the 234 reports related to the term glioma, 204 were selected for this study. Results: Astrocytic, ependymal and oligodendroglial tumors were found, with astrocytomas accounting for the majority (86.8% of the cases found). Mean age at diagnosis was 51.8 years and the prevalence was higher in men. Furthermore, immunohistochemically detectable mutations were analyzed, such as p53 (mutated in 66.7% of those tested), isocitrate dehydrogenase (IDH) (28.6% mutated), X-linked alpha-thalassemia mental retardation (ATRX) (21.0%) and diagnostic markers such as positive epithelial membrane antigen (EMA) in all analyzed ependymomas. Conclusion: The necessity of further researches on gliomas is undeniable , both epidemiologically considering the new classification and within the clinical and pathophysiological scope in order to improve the understanding of the pathology and the treatment for the patients.Introducción: Los gliomas representan 80% de los tumores del sistema nervioso central. La Organización Mundial de la Salud (OMS) agrego, en 2016, criterios moleculares sobre como clasificar los gliomas. La fisiopatología y los factores de riesgo de estos tumores aún no se comprenden completamente. Objetivo: Realizar un análisis retrospectivo de informes inmunohistoquímicos y anatomopatológicos de gliomas. Método: Estudio transversal, retrospectivo y descriptivo con base em pruebas anatomopatológicas e inmunohistoquímicas realizadas entre enero de 2014 y diciembre de 2018 en un laboratorio de anatomía patológica de la ciudad de Maringá-PR. De los 234 informes relacionados con el termino glioma, se seleccionaron 204 para este estudio. Resultados: Se encontraron tumores astrocíticos, ependimarios y oligodendrogliales, siendo los astrocitomas la mayoría (86,8% de los casos encontrados). La edad media al diagnóstico fue de 51,8 años y hubo una mayor prevalencia de estos tumores en el sexo masculino. También se analizaron mutaciones detectables inmunohistoquímicamente, como p53 (mutado en 66,7% de los analizados), isocitrato desidrogenase (IDH) (28,6% mutado), X-linked alpha-thalassemia mental retardation (ATRX) (21,0%) y marcadores de diagnóstico como epithelial membrane antigen (EMA) positivo en todos los ependimomas analizados. Conclusión: Es innegable la necesidad de profundizaren las investigaciones sobre los gliomas, tanto en el campo epidemiológico, ante la nueva clasificación, como en el ámbito fisiopatológico y clínico, con el objetivo de mejorar el conocimiento sobre la patología y el tratamiento de los pacientes.Introdução: Os gliomas representam 80% dos tumores do sistema nervoso central. A Organização Mundial da Saúde (OMS) adicionou, em 2016, critérios moleculares na classificação dos gliomas. A fisiopatologia e os fatores de risco desses tumores ainda não são totalmente conhecidos. Objetivo: Realizar uma análise retrospectiva dos laudos anatomopatológicos e imuno-histoquímicos de gliomas. Método: Estudo transversal, retrospectivo e descritivo, a partir de exames anatomopatológicos e imuno-histoquímicos realizados entre janeiro de 2014 e dezembro de 2018 em um laboratório de anatomia patológica na cidade de Maringá-PR. Dos 234 laudos relacionados com o termo glioma, 204 foram selecionados para este estudo. Resultados: Foram encontrados tumores astrocitários, ependimários e oligodendrogliais, sendo que os astrocitomas corresponderam a maioria (86,8% dos casos encontrados). A média de idade ao diagnóstico foi de 51,8 anos e houve maior prevalência desses tumores no sexo masculino. Também foram analisadas mutações detectáveis por imuno-histoquímica como p53 (mutada em 66,7% dos testados), isocitrato desidrogenase (IDH) (28,6% mutados), X-linked alpha-thalassemia mental retardation (ATRX) (21,0%) e marcadores diagnósticos como o epithelial membrane antigen (EMA) positivo em todos os ependimomas analisados. Conclusão: E inegável a necessidade de novas pesquisas sobre os gliomas tanto no campo epidemiológico, tendo em vista a nova classificação, quanto no escopo fisiopatológico e clinico, com o objetivo de melhorar o entendimento sobre a patologia e o tratamento dos pacientes.INCA2021-07-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/128710.32635/2176-9745.RBC.2021v67n3.1287Revista Brasileira de Cancerologia; Vol. 67 No. 3 (2021): July/Aug./Sept.; e-101287Revista Brasileira de Cancerologia; Vol. 67 Núm. 3 (2021): jul./ago./sept.; e-101287Revista Brasileira de Cancerologia; v. 67 n. 3 (2021): jul./ago./set.; e-1012872176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporenghttps://rbc.inca.gov.br/index.php/revista/article/view/1287/1402https://rbc.inca.gov.br/index.php/revista/article/view/1287/1470Copyright (c) 2021 Revista Brasileira de Cancerologiainfo:eu-repo/semantics/openAccessValadares, Adriana Domingues Souza-Kaneshima, Alice MariaKaneshima, Edilson Nobuyushi Fernandes, Igor Lima Jordão, Igor Passareli Souza, Paola da Costa Maftoum, Tarik Radi Campos 2021-11-29T18:25:10Zoai:rbc.inca.gov.br:article/1287Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T18:25:10Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Anatomopathological and Immunohistochemical Profile of Gliomas of Patients in the Region of Maringá-PR
Perfil Anatomopatológico e Inmunohistoquímico de Gliomas en Pacientes la Región de Maringá-PR
Perfil Anatomopatológico e Imuno-histoquímico de Gliomas de Pacientes da Região de Maringá-PR
title Anatomopathological and Immunohistochemical Profile of Gliomas of Patients in the Region of Maringá-PR
spellingShingle Anatomopathological and Immunohistochemical Profile of Gliomas of Patients in the Region of Maringá-PR
Anatomopathological and Immunohistochemical Profile of Gliomas of Patients in the Region of Maringá-PR
Valadares, Adriana Domingues
Glioma
Glioblastoma
Astrocitoma
Imuno-Histoquímica
Epidemiologia Molecular
Glioma
Glioblastoma
Astrocytoma
Immunohistochemistry
Molecular Epidemiology
Glioma
Glioblastoma
Astrocitoma
Inmunohistoquímica
Epidemiología Molecular
Valadares, Adriana Domingues
Glioma
Glioblastoma
Astrocitoma
Imuno-Histoquímica
Epidemiologia Molecular
Glioma
Glioblastoma
Astrocytoma
Immunohistochemistry
Molecular Epidemiology
Glioma
Glioblastoma
Astrocitoma
Inmunohistoquímica
Epidemiología Molecular
title_short Anatomopathological and Immunohistochemical Profile of Gliomas of Patients in the Region of Maringá-PR
title_full Anatomopathological and Immunohistochemical Profile of Gliomas of Patients in the Region of Maringá-PR
title_fullStr Anatomopathological and Immunohistochemical Profile of Gliomas of Patients in the Region of Maringá-PR
Anatomopathological and Immunohistochemical Profile of Gliomas of Patients in the Region of Maringá-PR
title_full_unstemmed Anatomopathological and Immunohistochemical Profile of Gliomas of Patients in the Region of Maringá-PR
Anatomopathological and Immunohistochemical Profile of Gliomas of Patients in the Region of Maringá-PR
title_sort Anatomopathological and Immunohistochemical Profile of Gliomas of Patients in the Region of Maringá-PR
author Valadares, Adriana Domingues
author_facet Valadares, Adriana Domingues
Valadares, Adriana Domingues
Souza-Kaneshima, Alice Maria
Kaneshima, Edilson Nobuyushi
Fernandes, Igor Lima
Jordão, Igor Passareli
Souza, Paola da Costa
Maftoum, Tarik Radi Campos
Souza-Kaneshima, Alice Maria
Kaneshima, Edilson Nobuyushi
Fernandes, Igor Lima
Jordão, Igor Passareli
Souza, Paola da Costa
Maftoum, Tarik Radi Campos
author_role author
author2 Souza-Kaneshima, Alice Maria
Kaneshima, Edilson Nobuyushi
Fernandes, Igor Lima
Jordão, Igor Passareli
Souza, Paola da Costa
Maftoum, Tarik Radi Campos
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Valadares, Adriana Domingues
Souza-Kaneshima, Alice Maria
Kaneshima, Edilson Nobuyushi
Fernandes, Igor Lima
Jordão, Igor Passareli
Souza, Paola da Costa
Maftoum, Tarik Radi Campos
dc.subject.por.fl_str_mv Glioma
Glioblastoma
Astrocitoma
Imuno-Histoquímica
Epidemiologia Molecular
Glioma
Glioblastoma
Astrocytoma
Immunohistochemistry
Molecular Epidemiology
Glioma
Glioblastoma
Astrocitoma
Inmunohistoquímica
Epidemiología Molecular
topic Glioma
Glioblastoma
Astrocitoma
Imuno-Histoquímica
Epidemiologia Molecular
Glioma
Glioblastoma
Astrocytoma
Immunohistochemistry
Molecular Epidemiology
Glioma
Glioblastoma
Astrocitoma
Inmunohistoquímica
Epidemiología Molecular
description Introduction: Gliomas represent 80% of the central nervous system tumors. World Health Organization (WHO) has added, in 2016, molecular features to the classification of gliomas. The pathophysiology and risk factors of these tumors are not yet fully understood. Objective: Perform a retrospective analysis of immunohistochemical and anatomopathological reports of gliomas. Method: Cross-sectional, retrospective and descriptive study carried out from anatomopathological and immunohistochemical exams made between January 2014 and December 2018 in a pathological anatomy laboratory in the city of Maringa-PR. Of the 234 reports related to the term glioma, 204 were selected for this study. Results: Astrocytic, ependymal and oligodendroglial tumors were found, with astrocytomas accounting for the majority (86.8% of the cases found). Mean age at diagnosis was 51.8 years and the prevalence was higher in men. Furthermore, immunohistochemically detectable mutations were analyzed, such as p53 (mutated in 66.7% of those tested), isocitrate dehydrogenase (IDH) (28.6% mutated), X-linked alpha-thalassemia mental retardation (ATRX) (21.0%) and diagnostic markers such as positive epithelial membrane antigen (EMA) in all analyzed ependymomas. Conclusion: The necessity of further researches on gliomas is undeniable , both epidemiologically considering the new classification and within the clinical and pathophysiological scope in order to improve the understanding of the pathology and the treatment for the patients.
publishDate 2021
dc.date.none.fl_str_mv 2021-07-21
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Artigos, Avaliado pelos pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1287
10.32635/2176-9745.RBC.2021v67n3.1287
url https://rbc.inca.gov.br/index.php/revista/article/view/1287
identifier_str_mv 10.32635/2176-9745.RBC.2021v67n3.1287
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1287/1402
https://rbc.inca.gov.br/index.php/revista/article/view/1287/1470
dc.rights.driver.fl_str_mv Copyright (c) 2021 Revista Brasileira de Cancerologia
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2021 Revista Brasileira de Cancerologia
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 67 No. 3 (2021): July/Aug./Sept.; e-101287
Revista Brasileira de Cancerologia; Vol. 67 Núm. 3 (2021): jul./ago./sept.; e-101287
Revista Brasileira de Cancerologia; v. 67 n. 3 (2021): jul./ago./set.; e-101287
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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dc.identifier.doi.none.fl_str_mv 10.32635/2176-9745.RBC.2021v67n3.1287

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