Genetic predictors of poor prognosis in Portuguese patients with Juvenile Idiopathic Arthritis: data from Reuma.pt

Bibliographic Details
Main Author: Mourão, Ana
Publication Date: 2015
Other Authors: Santos, Maria, Mendonça, Sílvia, Oliveira-Ramos, Filipa, Salgado, Manuel, Estanqueiro, Paula, Melo-Gomes, José, Martins, Fernando, Lopes, Ana, Bettencourt, Bruno Filipe, Bruges-Armas, Jácome, Costa, José, Furtado, Carolina, Figueira, Ricardo, Brito, Iva, Branco, Jaime, Fonseca, João Eurico, Canhao, Helena
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/51759
Summary: Copyright © 2015 Ana Filipa Mourão et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
id RCAP_a6decc0f972bfb997c2c84d37a566b3a
oai_identifier_str oai:repositorio.ulisboa.pt:10451/51759
network_acronym_str RCAP
network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository_id_str https://opendoar.ac.uk/repository/7160
spelling Genetic predictors of poor prognosis in Portuguese patients with Juvenile Idiopathic Arthritis: data from Reuma.ptCopyright © 2015 Ana Filipa Mourão et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Introduction: This study aimed to assess the genetic determinants of poor outcome in Portuguese patients with juvenile idiopathic arthritis (JIA). Methods: Our study was conducted in Reuma.pt, the Rheumatic Diseases Portuguese Register, which includes patients with JIA. We collected prospectively patient and disease characteristics and a blood sample for DNA analysis. Poor prognosis was defined as CHAQ/HAQ >0.75 at the last visit and/or the treatment with biological therapy. A selected panel of single nucleotide polymorphisms (SNPs) associated with susceptibility was studied to verify if there was association with poor prognosis. Results: Of the 812 patients with JIA registered in Reuma.pt, 267 had a blood sample and registered information used to define "poor prognosis." In univariate analysis, we found significant associations with poor prognosis for allele A of TNFA1P3/20 rs6920220, allele G of TRAF1/C5 rs3761847, and allele G of PTPN2 rs7234029. In multivariate models, the associations with TRAF1/C5 (1.96 [1.17-3.3]) remained significant at the 5% level, while TNFA1P3/20 and PTPN2 were no longer significant. Nevertheless, none of associations found was significant after the Bonferroni correction was applied. Conclusion: Our study does not confirm the association between a panel of selected SNP and poor prognosis in Portuguese patients with JIA.HindawiRepositório da Universidade de LisboaMourão, AnaSantos, MariaMendonça, SílviaOliveira-Ramos, FilipaSalgado, ManuelEstanqueiro, PaulaMelo-Gomes, JoséMartins, FernandoLopes, AnaBettencourt, Bruno FilipeBruges-Armas, JácomeCosta, JoséFurtado, CarolinaFigueira, RicardoBrito, IvaBranco, JaimeFonseca, João EuricoCanhao, Helena2022-03-15T16:55:29Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/51759engJournal of immunology research, 706515.2314-886110.1155/2015/7065152314-7156info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:42:33Zoai:repositorio.ulisboa.pt:10451/51759Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:22:43.687702Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Genetic predictors of poor prognosis in Portuguese patients with Juvenile Idiopathic Arthritis: data from Reuma.pt
title Genetic predictors of poor prognosis in Portuguese patients with Juvenile Idiopathic Arthritis: data from Reuma.pt
spellingShingle Genetic predictors of poor prognosis in Portuguese patients with Juvenile Idiopathic Arthritis: data from Reuma.pt
Mourão, Ana
title_short Genetic predictors of poor prognosis in Portuguese patients with Juvenile Idiopathic Arthritis: data from Reuma.pt
title_full Genetic predictors of poor prognosis in Portuguese patients with Juvenile Idiopathic Arthritis: data from Reuma.pt
title_fullStr Genetic predictors of poor prognosis in Portuguese patients with Juvenile Idiopathic Arthritis: data from Reuma.pt
title_full_unstemmed Genetic predictors of poor prognosis in Portuguese patients with Juvenile Idiopathic Arthritis: data from Reuma.pt
title_sort Genetic predictors of poor prognosis in Portuguese patients with Juvenile Idiopathic Arthritis: data from Reuma.pt
author Mourão, Ana
author_facet Mourão, Ana
Santos, Maria
Mendonça, Sílvia
Oliveira-Ramos, Filipa
Salgado, Manuel
Estanqueiro, Paula
Melo-Gomes, José
Martins, Fernando
Lopes, Ana
Bettencourt, Bruno Filipe
Bruges-Armas, Jácome
Costa, José
Furtado, Carolina
Figueira, Ricardo
Brito, Iva
Branco, Jaime
Fonseca, João Eurico
Canhao, Helena
author_role author
author2 Santos, Maria
Mendonça, Sílvia
Oliveira-Ramos, Filipa
Salgado, Manuel
Estanqueiro, Paula
Melo-Gomes, José
Martins, Fernando
Lopes, Ana
Bettencourt, Bruno Filipe
Bruges-Armas, Jácome
Costa, José
Furtado, Carolina
Figueira, Ricardo
Brito, Iva
Branco, Jaime
Fonseca, João Eurico
Canhao, Helena
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Mourão, Ana
Santos, Maria
Mendonça, Sílvia
Oliveira-Ramos, Filipa
Salgado, Manuel
Estanqueiro, Paula
Melo-Gomes, José
Martins, Fernando
Lopes, Ana
Bettencourt, Bruno Filipe
Bruges-Armas, Jácome
Costa, José
Furtado, Carolina
Figueira, Ricardo
Brito, Iva
Branco, Jaime
Fonseca, João Eurico
Canhao, Helena
description Copyright © 2015 Ana Filipa Mourão et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
2022-03-15T16:55:29Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/51759
url http://hdl.handle.net/10451/51759
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of immunology research, 706515.
2314-8861
10.1155/2015/706515
2314-7156
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hindawi
publisher.none.fl_str_mv Hindawi
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833601679225782272

Similar Items