Management of infections in rheumatic patients receiving biological therapies. the Portuguese Society of Rheumatology recommendations

Bibliographic Details
Main Author: Teixeira, Lídia
Publication Date: 2016
Other Authors: Fonseca, Ana Rita, Eugénio, Gisela, Rodrigues, Marília, Khmelinskii, Nikita, Fernandes, Sílvia, Serra, Sofia, Costa, Tiago, Santos, Maria
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/50258
Summary: © Sociedade Portuguesa de Reumatologia |
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spelling Management of infections in rheumatic patients receiving biological therapies. the Portuguese Society of Rheumatology recommendationsBiologicsInfectionsTreatmentRecommendations© Sociedade Portuguesa de Reumatologia |Introduction: Infections are a major cause of morbidity and mortality in systemic inflammatory rheumatic diseases and the management of infectious complications in patients under biological therapies deserves particular attention. Objective: Develop evidence-based recommendations for the management of infections in rheumatic patients receiving biological therapies. Methods: A search in PubMed (until 10 November 2014) and EMBASE (until 20 December 2014) databases was performed. Patients with systemic inflammatory rheumatic diseases treated with approved biologics in whom infections occurred were included. Search results were submitted to title and abstract selection, followed by detailed review of suitable studies. Information regarding presentation of the infectious complication, its diagnosis, treatment, and outcome, as well as maintenance or discontinuation of the biological agent was extracted and subsequently pooled according to the type of infection considered. Results of literature review were presented and critically reviewed in a dedicated meeting by a multidisciplinary panel. Recommendations were then formulated using the Delphi method. Finally, the level of agreement among rheumatologists was voted using an online survey. Results: Fifteen recommendations were issued. Nine general recommendations concerned the assessment of infectious risk before and while on biologics, the procedures in case of suspected infection and the management of biologics during infectious complications. Six specific recommendations were developed for respiratory, urinary, gastrointestinal, skin, osteoarticular and disseminated infections. Conclusion: These fifteen recommendations are intended to help rheumatologists in the management of infections in patients on biological therapy. They integrate an extensive literature review, expert opinion and inputs from Portuguese rheumatologists.Sociedade Portuguesa de ReumatologiaRepositório da Universidade de LisboaTeixeira, LídiaFonseca, Ana RitaEugénio, GiselaRodrigues, MaríliaKhmelinskii, NikitaFernandes, SílviaSerra, SofiaCosta, TiagoSantos, Maria2021-12-02T17:39:02Z20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50258engActa Reumatologica Portuguesa, 41(4), 287–3040303-464X2184-8777info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:38:32Zoai:repositorio.ulisboa.pt:10451/50258Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:19:25.549563Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Management of infections in rheumatic patients receiving biological therapies. the Portuguese Society of Rheumatology recommendations
title Management of infections in rheumatic patients receiving biological therapies. the Portuguese Society of Rheumatology recommendations
spellingShingle Management of infections in rheumatic patients receiving biological therapies. the Portuguese Society of Rheumatology recommendations
Teixeira, Lídia
Biologics
Infections
Treatment
Recommendations
title_short Management of infections in rheumatic patients receiving biological therapies. the Portuguese Society of Rheumatology recommendations
title_full Management of infections in rheumatic patients receiving biological therapies. the Portuguese Society of Rheumatology recommendations
title_fullStr Management of infections in rheumatic patients receiving biological therapies. the Portuguese Society of Rheumatology recommendations
title_full_unstemmed Management of infections in rheumatic patients receiving biological therapies. the Portuguese Society of Rheumatology recommendations
title_sort Management of infections in rheumatic patients receiving biological therapies. the Portuguese Society of Rheumatology recommendations
author Teixeira, Lídia
author_facet Teixeira, Lídia
Fonseca, Ana Rita
Eugénio, Gisela
Rodrigues, Marília
Khmelinskii, Nikita
Fernandes, Sílvia
Serra, Sofia
Costa, Tiago
Santos, Maria
author_role author
author2 Fonseca, Ana Rita
Eugénio, Gisela
Rodrigues, Marília
Khmelinskii, Nikita
Fernandes, Sílvia
Serra, Sofia
Costa, Tiago
Santos, Maria
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Teixeira, Lídia
Fonseca, Ana Rita
Eugénio, Gisela
Rodrigues, Marília
Khmelinskii, Nikita
Fernandes, Sílvia
Serra, Sofia
Costa, Tiago
Santos, Maria
dc.subject.por.fl_str_mv Biologics
Infections
Treatment
Recommendations
topic Biologics
Infections
Treatment
Recommendations
description © Sociedade Portuguesa de Reumatologia |
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-01-01T00:00:00Z
2021-12-02T17:39:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/50258
url http://hdl.handle.net/10451/50258
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Acta Reumatologica Portuguesa, 41(4), 287–304
0303-464X
2184-8777
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Reumatologia
publisher.none.fl_str_mv Sociedade Portuguesa de Reumatologia
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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