Oral glucose lowering drugs in type 2 diabetic patients with chronic kidney disease

Bibliographic Details
Main Author: Nogueira, C
Publication Date: 2013
Other Authors: Souto, SB, Vinha, E, Carvalho-Braga, D, Carvalho, D
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10400.23/671
Summary: Chronic kidney disease (CKD) represents a challenge in the treatment of type 2 diabetic patients. Renal impairment may affect drug clearance and other pharmacokinetic processes which can increase toxicity and drug to drug interactions or cause ineffective therapy. There are many oral glucose lowering drugs available for the treatment of type 2 diabetes mellitus (T2DM) with different mechanisms of action and different pharmacokinetic profiles. While all classes may be used in patients with mild renal impairment, therapeutic options for patients with moderate to severe CKD are still limited. This review focuses on the pharmacokinetics, metabolism, and safety of oral glucose lowering drugs in patients with T2DM and CKD.
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spelling Oral glucose lowering drugs in type 2 diabetic patients with chronic kidney diseaseDiabetes Mellitus Tipo 2HipoglicemiantesInsuficiência Renal CrónicaChronic kidney disease (CKD) represents a challenge in the treatment of type 2 diabetic patients. Renal impairment may affect drug clearance and other pharmacokinetic processes which can increase toxicity and drug to drug interactions or cause ineffective therapy. There are many oral glucose lowering drugs available for the treatment of type 2 diabetes mellitus (T2DM) with different mechanisms of action and different pharmacokinetic profiles. While all classes may be used in patients with mild renal impairment, therapeutic options for patients with moderate to severe CKD are still limited. This review focuses on the pharmacokinetics, metabolism, and safety of oral glucose lowering drugs in patients with T2DM and CKD.Repositório Científico do Hospital de BragaNogueira, CSouto, SBVinha, ECarvalho-Braga, DCarvalho, D2014-07-28T20:47:29Z2013-01-01T00:00:00Z2013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.23/671engHormones. 2013 Oct-Dec;12(4):483-94info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2022-09-21T09:02:23Zoai:repositorio.hospitaldebraga.pt:10400.23/671Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T10:15:21.081718Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Oral glucose lowering drugs in type 2 diabetic patients with chronic kidney disease
title Oral glucose lowering drugs in type 2 diabetic patients with chronic kidney disease
spellingShingle Oral glucose lowering drugs in type 2 diabetic patients with chronic kidney disease
Nogueira, C
Diabetes Mellitus Tipo 2
Hipoglicemiantes
Insuficiência Renal Crónica
title_short Oral glucose lowering drugs in type 2 diabetic patients with chronic kidney disease
title_full Oral glucose lowering drugs in type 2 diabetic patients with chronic kidney disease
title_fullStr Oral glucose lowering drugs in type 2 diabetic patients with chronic kidney disease
title_full_unstemmed Oral glucose lowering drugs in type 2 diabetic patients with chronic kidney disease
title_sort Oral glucose lowering drugs in type 2 diabetic patients with chronic kidney disease
author Nogueira, C
author_facet Nogueira, C
Souto, SB
Vinha, E
Carvalho-Braga, D
Carvalho, D
author_role author
author2 Souto, SB
Vinha, E
Carvalho-Braga, D
Carvalho, D
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Hospital de Braga
dc.contributor.author.fl_str_mv Nogueira, C
Souto, SB
Vinha, E
Carvalho-Braga, D
Carvalho, D
dc.subject.por.fl_str_mv Diabetes Mellitus Tipo 2
Hipoglicemiantes
Insuficiência Renal Crónica
topic Diabetes Mellitus Tipo 2
Hipoglicemiantes
Insuficiência Renal Crónica
description Chronic kidney disease (CKD) represents a challenge in the treatment of type 2 diabetic patients. Renal impairment may affect drug clearance and other pharmacokinetic processes which can increase toxicity and drug to drug interactions or cause ineffective therapy. There are many oral glucose lowering drugs available for the treatment of type 2 diabetes mellitus (T2DM) with different mechanisms of action and different pharmacokinetic profiles. While all classes may be used in patients with mild renal impairment, therapeutic options for patients with moderate to severe CKD are still limited. This review focuses on the pharmacokinetics, metabolism, and safety of oral glucose lowering drugs in patients with T2DM and CKD.
publishDate 2013
dc.date.none.fl_str_mv 2013-01-01T00:00:00Z
2013-01-01T00:00:00Z
2014-07-28T20:47:29Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.23/671
url http://hdl.handle.net/10400.23/671
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Hormones. 2013 Oct-Dec;12(4):483-94
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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