Erythrocyte reactive nitrogen species in health and disease

Bibliographic Details
Main Author: Saldanha, Carlota
Publication Date: 2018
Other Authors: Silva-Herdade, Ana S.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/44628
Summary: Copyright: © 2018 Saldanha C. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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spelling Erythrocyte reactive nitrogen species in health and diseaseErythrocyteNitric oxidePeroxynitriteNitriteNitrateS-nitrosoglutathionePhosphoinositide-3 kinaseAdenylyl cyclaseCopyright: © 2018 Saldanha C. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.In general, reactive nitrogen species, like nitric oxide (NO) and peroxynitrite are classified in primary and secondary according its benefic or deleterious effects respectively. Multiple benefic roles through the body has been attributed to nitric oxide (NO), a key signaling molecule, which acts as vasodilator relaxing smooth muscles of arteries; participates in the blood pressure control; hinders the initiation of inflammation NO liberated from endothelium cells or lymphocytes to intravascular corporal fluid enter into erythrocytes through membrane band 3 protein being after captured by deoxyhemoglobin or by oxyhemoglobin. Inside the erythrocytes several chemical reactions occur with generation of S-nitrosoglutathione a NO reservoir molecules and NO derivatives (NOx) molecules namely nitrite, nitrate and peroxynitrite. The erythrocyte acts as sensor of the tissues oxygen partial pressure and consequently change its oxygen levels lead along with NO contents. NO is released through band 3 protein into the blood, at microcirculatory network, in tissues with low oxygen partial pressure. The aim of this mini review was to present the erythrocyte signal transduction pathways associated with NO and S-nitrosoglutathione efflux, metabolic behavior of the NO reservoir molecules and NO reactive species in human erythrocytes under several biological conditions. For examples, the effects of external amphipathic molecules, fibrinogen, and internal manipulation of protein phosphorylation degree and redox status on erythrocyte. NOx, NO and S-nitrosoglutathione efflux levels are herein included. Erythrocyte NO efflux evidenced as biomarkers of inflammatory vascular diseases will be herein highlighted.This work was funded by Fundação para a Ciência e Tecnologia: LISBOA-01-0145-FEDER-007391, project cofunded by FEDER, through POR Lisboa 2020 - Programa Operacional Regional de Lisboa, PORTUGAL 2020.Open Access TextRepositório da Universidade de LisboaSaldanha, CarlotaSilva-Herdade, Ana S.2020-10-21T11:08:09Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/44628engClin Med Invest, 2018, Volume 3(2): 1-410.15761/CMI.10001612398-5763info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:23:15Zoai:repositorio.ulisboa.pt:10451/44628Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:10:54.852884Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Erythrocyte reactive nitrogen species in health and disease
title Erythrocyte reactive nitrogen species in health and disease
spellingShingle Erythrocyte reactive nitrogen species in health and disease
Saldanha, Carlota
Erythrocyte
Nitric oxide
Peroxynitrite
Nitrite
Nitrate
S-nitrosoglutathione
Phosphoinositide-3 kinase
Adenylyl cyclase
title_short Erythrocyte reactive nitrogen species in health and disease
title_full Erythrocyte reactive nitrogen species in health and disease
title_fullStr Erythrocyte reactive nitrogen species in health and disease
title_full_unstemmed Erythrocyte reactive nitrogen species in health and disease
title_sort Erythrocyte reactive nitrogen species in health and disease
author Saldanha, Carlota
author_facet Saldanha, Carlota
Silva-Herdade, Ana S.
author_role author
author2 Silva-Herdade, Ana S.
author2_role author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Saldanha, Carlota
Silva-Herdade, Ana S.
dc.subject.por.fl_str_mv Erythrocyte
Nitric oxide
Peroxynitrite
Nitrite
Nitrate
S-nitrosoglutathione
Phosphoinositide-3 kinase
Adenylyl cyclase
topic Erythrocyte
Nitric oxide
Peroxynitrite
Nitrite
Nitrate
S-nitrosoglutathione
Phosphoinositide-3 kinase
Adenylyl cyclase
description Copyright: © 2018 Saldanha C. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
2020-10-21T11:08:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/44628
url http://hdl.handle.net/10451/44628
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Clin Med Invest, 2018, Volume 3(2): 1-4
10.15761/CMI.1000161
2398-5763
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Open Access Text
publisher.none.fl_str_mv Open Access Text
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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