Optimization of simulated moving bed processes for multicomponent chiral separations

Detalhes bibliográficos
Autor(a) principal: Ribeiro, António E.
Data de Publicação: 2012
Outros Autores: Rodrigues, Alírio, Pais, Luís S.
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://hdl.handle.net/10198/9139
Resumo: This work will present and discuss the experimental and simulation results obtained for the analytical and preparative separation of the four stereoisomers of nadolol, an important example of a non-selective beta-adrenergic receptor antagonist (beta-blocker) pharmaceutical drug, widely used in the treatment of cardiovascular system diseases, such as hypertension, ischemic heart disease (angina pectoris), congestive heart failure and certain arrhythmias. The main focus will be placed in the selection of the proper CSP/solvent combination for SMB operation. Experimental results will be presented using Chiralpak AD and Chiralpak IA CSP (Daicel, Europe) and different mixtures of alkanes, alcohols and acetonitrile as solvent.
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spelling Optimization of simulated moving bed processes for multicomponent chiral separationsMulticomponentChiral separationSimulated moving-bedThis work will present and discuss the experimental and simulation results obtained for the analytical and preparative separation of the four stereoisomers of nadolol, an important example of a non-selective beta-adrenergic receptor antagonist (beta-blocker) pharmaceutical drug, widely used in the treatment of cardiovascular system diseases, such as hypertension, ischemic heart disease (angina pectoris), congestive heart failure and certain arrhythmias. The main focus will be placed in the selection of the proper CSP/solvent combination for SMB operation. Experimental results will be presented using Chiralpak AD and Chiralpak IA CSP (Daicel, Europe) and different mixtures of alkanes, alcohols and acetonitrile as solvent.Biblioteca Digital do IPBRibeiro, António E.Rodrigues, AlírioPais, Luís S.2014-01-13T13:21:42Z20122012-01-01T00:00:00Zconference objectinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10198/9139engRibeiro, António E.; Rodrigues, A.E.; Pais, L.S. (2012). Optimization of simulated moving bed processes for multicomponent chiral separations. In SPICA 2012 14th International Symposium on Preparative and Industrial Chromatography and Allied Techniques. Brussels, Belgiuminfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-02-25T12:00:41Zoai:bibliotecadigital.ipb.pt:10198/9139Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T11:24:56.162865Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Optimization of simulated moving bed processes for multicomponent chiral separations
title Optimization of simulated moving bed processes for multicomponent chiral separations
spellingShingle Optimization of simulated moving bed processes for multicomponent chiral separations
Ribeiro, António E.
Multicomponent
Chiral separation
Simulated moving-bed
title_short Optimization of simulated moving bed processes for multicomponent chiral separations
title_full Optimization of simulated moving bed processes for multicomponent chiral separations
title_fullStr Optimization of simulated moving bed processes for multicomponent chiral separations
title_full_unstemmed Optimization of simulated moving bed processes for multicomponent chiral separations
title_sort Optimization of simulated moving bed processes for multicomponent chiral separations
author Ribeiro, António E.
author_facet Ribeiro, António E.
Rodrigues, Alírio
Pais, Luís S.
author_role author
author2 Rodrigues, Alírio
Pais, Luís S.
author2_role author
author
dc.contributor.none.fl_str_mv Biblioteca Digital do IPB
dc.contributor.author.fl_str_mv Ribeiro, António E.
Rodrigues, Alírio
Pais, Luís S.
dc.subject.por.fl_str_mv Multicomponent
Chiral separation
Simulated moving-bed
topic Multicomponent
Chiral separation
Simulated moving-bed
description This work will present and discuss the experimental and simulation results obtained for the analytical and preparative separation of the four stereoisomers of nadolol, an important example of a non-selective beta-adrenergic receptor antagonist (beta-blocker) pharmaceutical drug, widely used in the treatment of cardiovascular system diseases, such as hypertension, ischemic heart disease (angina pectoris), congestive heart failure and certain arrhythmias. The main focus will be placed in the selection of the proper CSP/solvent combination for SMB operation. Experimental results will be presented using Chiralpak AD and Chiralpak IA CSP (Daicel, Europe) and different mixtures of alkanes, alcohols and acetonitrile as solvent.
publishDate 2012
dc.date.none.fl_str_mv 2012
2012-01-01T00:00:00Z
2014-01-13T13:21:42Z
dc.type.driver.fl_str_mv conference object
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10198/9139
url http://hdl.handle.net/10198/9139
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Ribeiro, António E.; Rodrigues, A.E.; Pais, L.S. (2012). Optimization of simulated moving bed processes for multicomponent chiral separations. In SPICA 2012 14th International Symposium on Preparative and Industrial Chromatography and Allied Techniques. Brussels, Belgium
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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