Non-vitamin K oral anticoagulants assessment in high risk of bleeding patients with non-valvular atrial fibrillation

Bibliographic Details
Main Author: Silva Cunha, Pedro
Publication Date: 2022
Other Authors: Viveiros Monteiro, André, Coutinho Cruz, Madalena, Malveiro, Paula, Reis, João Pedro, Portugal, Guilherme, Dias, Ana, Ferreira, Rui Cruz, Oliveira, Mario
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/51519
Summary: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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spelling Non-vitamin K oral anticoagulants assessment in high risk of bleeding patients with non-valvular atrial fibrillationAnticoagulation unitAtrial fibrillationNon-vitamin K oral anticoagulants© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Atrial fibrillation (AF) is commonly associated with advanced age and the presence of multiple, concomitant acute and chronic health conditions, placing this population at high risk for serious therapeutic side effects. Nonvitamin K antagonist oral anticoagulants (NOACs) are increasingly used for stroke prevention in patients with atrial fibrillation. The purpose of this study was to investigate the effectiveness and safety of NOAC in a group at high risk of bleeding complications, in a real-world setting. We conducted a retrospective analysis of a high-risk cohort of 418 patients (pts) followed-up in our anticoagulation unit; data on patient characteristics, anticoagulation treatment, and bleeding and thrombotic complications were evaluated. The population had a median age of 77.8 ± 10.3 years and the mean CHA2DS2-VASc score was 3.85 (SD ± 1.4). Overall, 289 (69.1%) were ≥75 years old. During a mean follow-up time of 51.2 ± 35.7 months, we observed a rate of any bleeding of 7, a clinically relevant non-major bleeding rate of 4.8, a major bleeding rate of 2.2, a stroke rate of 1.6, and a rate of thrombotic events of 0.28 per 100 patient-years. There were 59 hospitalizations due to any cause (14.1%) and 36 (8.6%) deaths (one due to ischemic stroke). A structured follow-up, with judicious prescribing and drug compliance, may contribute to preventing potential complications.MDPIRepositório da Universidade de LisboaSilva Cunha, PedroViveiros Monteiro, AndréCoutinho Cruz, MadalenaMalveiro, PaulaReis, João PedroPortugal, GuilhermeDias, AnaFerreira, Rui CruzOliveira, Mario2022-02-25T16:09:53Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/51519engGeriatrics (Basel). 2022 Feb 17;7(1):2010.3390/geriatrics70100202308-3417info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:41:58Zoai:repositorio.ulisboa.pt:10451/51519Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:22:28.634822Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Non-vitamin K oral anticoagulants assessment in high risk of bleeding patients with non-valvular atrial fibrillation
title Non-vitamin K oral anticoagulants assessment in high risk of bleeding patients with non-valvular atrial fibrillation
spellingShingle Non-vitamin K oral anticoagulants assessment in high risk of bleeding patients with non-valvular atrial fibrillation
Silva Cunha, Pedro
Anticoagulation unit
Atrial fibrillation
Non-vitamin K oral anticoagulants
title_short Non-vitamin K oral anticoagulants assessment in high risk of bleeding patients with non-valvular atrial fibrillation
title_full Non-vitamin K oral anticoagulants assessment in high risk of bleeding patients with non-valvular atrial fibrillation
title_fullStr Non-vitamin K oral anticoagulants assessment in high risk of bleeding patients with non-valvular atrial fibrillation
title_full_unstemmed Non-vitamin K oral anticoagulants assessment in high risk of bleeding patients with non-valvular atrial fibrillation
title_sort Non-vitamin K oral anticoagulants assessment in high risk of bleeding patients with non-valvular atrial fibrillation
author Silva Cunha, Pedro
author_facet Silva Cunha, Pedro
Viveiros Monteiro, André
Coutinho Cruz, Madalena
Malveiro, Paula
Reis, João Pedro
Portugal, Guilherme
Dias, Ana
Ferreira, Rui Cruz
Oliveira, Mario
author_role author
author2 Viveiros Monteiro, André
Coutinho Cruz, Madalena
Malveiro, Paula
Reis, João Pedro
Portugal, Guilherme
Dias, Ana
Ferreira, Rui Cruz
Oliveira, Mario
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Silva Cunha, Pedro
Viveiros Monteiro, André
Coutinho Cruz, Madalena
Malveiro, Paula
Reis, João Pedro
Portugal, Guilherme
Dias, Ana
Ferreira, Rui Cruz
Oliveira, Mario
dc.subject.por.fl_str_mv Anticoagulation unit
Atrial fibrillation
Non-vitamin K oral anticoagulants
topic Anticoagulation unit
Atrial fibrillation
Non-vitamin K oral anticoagulants
description © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
publishDate 2022
dc.date.none.fl_str_mv 2022-02-25T16:09:53Z
2022
2022-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/51519
url http://hdl.handle.net/10451/51519
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Geriatrics (Basel). 2022 Feb 17;7(1):20
10.3390/geriatrics7010020
2308-3417
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833601677479903232

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