Acute corneal allograft rejection following SARS-CoV-2 vaccination–A systematic review

Detalhes bibliográficos
Autor(a) principal: Moura-Coelho, Nuno
Data de Publicação: 2023
Outros Autores: Cunha, João Paulo, Papa-Vettorazzi, Renato, Gris, Óscar, Güell, José Luis
Tipo de documento: Outros
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://hdl.handle.net/10362/151467
Resumo: Publisher Copyright: © 2022 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.
id RCAP_9ead5161f2bc74aee73223ebe02dfb87
oai_identifier_str oai:run.unl.pt:10362/151467
network_acronym_str RCAP
network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository_id_str https://opendoar.ac.uk/repository/7160
spelling Acute corneal allograft rejection following SARS-CoV-2 vaccination–A systematic reviewcoronaviruskeratoplastyrejectionvaccinesOphthalmologySDG 3 - Good Health and Well-beingPublisher Copyright: © 2022 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.All documented cases of acute corneal allograft rejection following SARS-CoV-2 vaccination were examined, to characterize possible risk factors and graft outcomes. Comprehensive search (4 electronic databases: PubMed, CENTRAL, ClinicalTrials.gov, Google Scholar, plus manual search in articles' reference lists) until March 1st 2022 to identify studies reporting acute corneal allograft rejection following SARS-CoV-2 vaccination; study protocol was developed in line with PRISMA statement. We analysed demographics, allograft type, rejection prophylaxis regime at the time of vaccination, transplantation-to-vaccination time (G-Vt), vaccination-to-immune reaction onset time (V-Rt), management, best-corrected visual acuity before and after rejection, and graft survival. Of 169 titles/abstracts screened, 16 studies (n = 36 eyes) met the inclusion criteria. Fourteen eyes (38.9%) had received >1 graft, and 11.1% of cases had history of immune reactions; 52.9% of cases occurred after the first dose. Median (P25-P75) G-Vt was 48 (10–78) months; median V-Rt was 9 (7–14) days. In eyes with resolved rejection, median time-to-resolution was 3 (1–4) weeks. Four eyes (11.1%) had partial resolution of corneal decompensation, and 5 grafts (13.9%) failed. Acute corneal allograft rejection after SARS-CoV-2 vaccination is a rare event, but may occur any time post-keratoplasty. Early recognition and prompt, aggressive treatment is warranted to optimize vision and graft survival. Well-known risk factors for rejection may be confounding factors, including the high proportion of cases with a history of previous grafts and the rejection prophylaxis regimes at the time of vaccination. Increasing immunosuppressants in the peri-vaccination period may decrease the risk of immune reactions, especially in high-risk cases.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNMoura-Coelho, NunoCunha, João PauloPapa-Vettorazzi, RenatoGris, ÓscarGüell, José Luis2023-03-31T22:17:04Z2023-022023-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://hdl.handle.net/10362/151467eng1755-375XPURE: 45347947https://doi.org/10.1111/aos.15211info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:10:43Zoai:run.unl.pt:10362/151467Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:41:07.611247Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Acute corneal allograft rejection following SARS-CoV-2 vaccination–A systematic review
title Acute corneal allograft rejection following SARS-CoV-2 vaccination–A systematic review
spellingShingle Acute corneal allograft rejection following SARS-CoV-2 vaccination–A systematic review
Moura-Coelho, Nuno
coronavirus
keratoplasty
rejection
vaccines
Ophthalmology
SDG 3 - Good Health and Well-being
title_short Acute corneal allograft rejection following SARS-CoV-2 vaccination–A systematic review
title_full Acute corneal allograft rejection following SARS-CoV-2 vaccination–A systematic review
title_fullStr Acute corneal allograft rejection following SARS-CoV-2 vaccination–A systematic review
title_full_unstemmed Acute corneal allograft rejection following SARS-CoV-2 vaccination–A systematic review
title_sort Acute corneal allograft rejection following SARS-CoV-2 vaccination–A systematic review
author Moura-Coelho, Nuno
author_facet Moura-Coelho, Nuno
Cunha, João Paulo
Papa-Vettorazzi, Renato
Gris, Óscar
Güell, José Luis
author_role author
author2 Cunha, João Paulo
Papa-Vettorazzi, Renato
Gris, Óscar
Güell, José Luis
author2_role author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Moura-Coelho, Nuno
Cunha, João Paulo
Papa-Vettorazzi, Renato
Gris, Óscar
Güell, José Luis
dc.subject.por.fl_str_mv coronavirus
keratoplasty
rejection
vaccines
Ophthalmology
SDG 3 - Good Health and Well-being
topic coronavirus
keratoplasty
rejection
vaccines
Ophthalmology
SDG 3 - Good Health and Well-being
description Publisher Copyright: © 2022 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.
publishDate 2023
dc.date.none.fl_str_mv 2023-03-31T22:17:04Z
2023-02
2023-02-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/151467
url http://hdl.handle.net/10362/151467
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1755-375X
PURE: 45347947
https://doi.org/10.1111/aos.15211
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833596891079639040

Registros relacionados