Anaplastic thyroid cancer: How far can we go?

Bibliographic Details
Main Author: Amaral, Mariana
Publication Date: 2020
Other Authors: Afonso, Ricardo A., Gaspar, M. Manuela, Reis, Catarina Pinto
Format: Other
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/101654
Summary: This research was funded by Fundacao para a Ciencia e a Tecnologia (FCT) through the Project Reference UID/DTP/04138/2019.
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oai_identifier_str oai:run.unl.pt:10362/101654
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network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository_id_str https://opendoar.ac.uk/repository/7160
spelling Anaplastic thyroid cancer: How far can we go?Anaplastic thyroid cancerChallenges for innovative therapiesTreatments and obstaclesMolecular MedicineAnimal Science and ZoologyPharmacologyDrug DiscoverySDG 3 - Good Health and Well-beingThis research was funded by Fundacao para a Ciencia e a Tecnologia (FCT) through the Project Reference UID/DTP/04138/2019.Globally, thyroid cancer accounts for 2 % of all cancer diagnoses, and can be classified as well-differentiated or undifferentiated. Currently, differentiated thyroid carcinomas have good prognoses, and can be treated with a combination of therapies, including surgical thyroidectomy, radioactive iodine therapy and hormone-based ther-apy. On the other hand, anaplastic thyroid carcinoma, a subtype of undifferentiated thyroid carcinoma character-ized by the loss of thyroid-like phenotype and function, does not respond to either radioactive iodine or hormone therapies. In most cases, anaplastic thyroid carcinomas are diagnosed in later stages of the disease, deeming them inoperable, and showing poor response rates to systemic chemotherapy. Recently, treatment courses using multi-ple-target agents are being explored and clinical trials have shown very promising results, such as overall survival rates, progression-free survival and tumor shrinkage. This review is focused on thyroid carcinomas, with particular focus on anaplastic thyroid carcinoma, exploring its undifferentiated nature. Special interest will be given to the treatment approaches currently available and respective obstacles or drawbacks. Our purpose is to contribute to understand why this malignancy presents low responsiveness to current treatments, while overviewing novel therapies and clinical trials.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)DF – Departamento de FísicaCentro de Estudos de Doenças Crónicas (CEDOC)RUNAmaral, MarianaAfonso, Ricardo A.Gaspar, M. ManuelaReis, Catarina Pinto2020-07-28T22:23:55Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/other13application/pdfhttp://hdl.handle.net/10362/101654eng1611-2156PURE: 19235932https://doi.org/10.17179/excli2020-2257info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:46:46Zoai:run.unl.pt:10362/101654Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:17:48.404982Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Anaplastic thyroid cancer: How far can we go?
title Anaplastic thyroid cancer: How far can we go?
spellingShingle Anaplastic thyroid cancer: How far can we go?
Amaral, Mariana
Anaplastic thyroid cancer
Challenges for innovative therapies
Treatments and obstacles
Molecular Medicine
Animal Science and Zoology
Pharmacology
Drug Discovery
SDG 3 - Good Health and Well-being
title_short Anaplastic thyroid cancer: How far can we go?
title_full Anaplastic thyroid cancer: How far can we go?
title_fullStr Anaplastic thyroid cancer: How far can we go?
title_full_unstemmed Anaplastic thyroid cancer: How far can we go?
title_sort Anaplastic thyroid cancer: How far can we go?
author Amaral, Mariana
author_facet Amaral, Mariana
Afonso, Ricardo A.
Gaspar, M. Manuela
Reis, Catarina Pinto
author_role author
author2 Afonso, Ricardo A.
Gaspar, M. Manuela
Reis, Catarina Pinto
author2_role author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
DF – Departamento de Física
Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv Amaral, Mariana
Afonso, Ricardo A.
Gaspar, M. Manuela
Reis, Catarina Pinto
dc.subject.por.fl_str_mv Anaplastic thyroid cancer
Challenges for innovative therapies
Treatments and obstacles
Molecular Medicine
Animal Science and Zoology
Pharmacology
Drug Discovery
SDG 3 - Good Health and Well-being
topic Anaplastic thyroid cancer
Challenges for innovative therapies
Treatments and obstacles
Molecular Medicine
Animal Science and Zoology
Pharmacology
Drug Discovery
SDG 3 - Good Health and Well-being
description This research was funded by Fundacao para a Ciencia e a Tecnologia (FCT) through the Project Reference UID/DTP/04138/2019.
publishDate 2020
dc.date.none.fl_str_mv 2020-07-28T22:23:55Z
2020
2020-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/101654
url http://hdl.handle.net/10362/101654
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1611-2156
PURE: 19235932
https://doi.org/10.17179/excli2020-2257
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13
application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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