Application of OSN in membrane cascade for purification of the API Amoxicillin

Detalhes bibliográficos
Autor(a) principal: Ferreira, Susana Cristina Dias Ramos
Data de Publicação: 2013
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://hdl.handle.net/10362/10710
Resumo: Dissertação para obtenção do Grau de Mestre em Engenharia Química e Bioquímica
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spelling Application of OSN in membrane cascade for purification of the API AmoxicillinAmoxicillinPurificationOrganic solvent nanofiltration (OSN)Active pharmaceutical ingredients (API)Membrane cascadeDissertação para obtenção do Grau de Mestre em Engenharia Química e BioquímicaThe present work developed at Imperial College London (ICL) in collaboration with the Massachusetts Institute of Technology (MIT) had the objective of purifying the API amoxicillin containing an initial concentration of 30ppm of the compound 4-hydroxy-l-phenylglycine (impurity) using an OSN membrane cascade. Project proposal:  Solubility and stability studies of the API in different solvents.  Solvent choice for the separation process.  Dissociation study of the API and impurity to exploit a promising optimization of the process.  Membrane screening using dead-end and m-CSTR upside-down measurements.  Process modeling and simulation of different configurations Amoxicillin showed to be a sensitive compound to work with having a low solubility and a fast decomposition in the studied solvents. The solvents tested in detail were water, acetone, ethanol and methanol, being water the one choose to performed the purification. From the dissociation study it was possible to understand the possible exploitation of the pH parameter in the optimization of the separation process. In the membrane screening the effect of pressure and pH were studied in six types of membranes. It could be conclude that the main obstacle for the purification process was the membrane performance itself, with insufficient separation between the compounds (difference of 10 p.p. in rejection). The most promising results were obtained using the TFNF-DL membrane, with an API rejection of 99.12% and an impurity rejection of 87.80%. The process modelling was performed in a semi-batch mode with one and two stages, respectively, and in continuous mode with two-stages and two different configurations. An increase from two to three stages was also analyzed for the continuous configuration II. A maximum purity of 99.65% with a yield of 97.86% was obtained with the semi-batch two-stage cascade system. From the continuous three stage cascade system, a purity of 98.65% and a yield of 98.54% were achieved.Faculdade de Ciências e TecnologiaLivingston, AndrewCoelhoso, IsabelRUNFerreira, Susana Cristina Dias Ramos2013-11-12T11:37:48Z20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10362/10710enginfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:14:30Zoai:run.unl.pt:10362/10710Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T16:45:36.498803Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Application of OSN in membrane cascade for purification of the API Amoxicillin
title Application of OSN in membrane cascade for purification of the API Amoxicillin
spellingShingle Application of OSN in membrane cascade for purification of the API Amoxicillin
Ferreira, Susana Cristina Dias Ramos
Amoxicillin
Purification
Organic solvent nanofiltration (OSN)
Active pharmaceutical ingredients (API)
Membrane cascade
title_short Application of OSN in membrane cascade for purification of the API Amoxicillin
title_full Application of OSN in membrane cascade for purification of the API Amoxicillin
title_fullStr Application of OSN in membrane cascade for purification of the API Amoxicillin
title_full_unstemmed Application of OSN in membrane cascade for purification of the API Amoxicillin
title_sort Application of OSN in membrane cascade for purification of the API Amoxicillin
author Ferreira, Susana Cristina Dias Ramos
author_facet Ferreira, Susana Cristina Dias Ramos
author_role author
dc.contributor.none.fl_str_mv Livingston, Andrew
Coelhoso, Isabel
RUN
dc.contributor.author.fl_str_mv Ferreira, Susana Cristina Dias Ramos
dc.subject.por.fl_str_mv Amoxicillin
Purification
Organic solvent nanofiltration (OSN)
Active pharmaceutical ingredients (API)
Membrane cascade
topic Amoxicillin
Purification
Organic solvent nanofiltration (OSN)
Active pharmaceutical ingredients (API)
Membrane cascade
description Dissertação para obtenção do Grau de Mestre em Engenharia Química e Bioquímica
publishDate 2013
dc.date.none.fl_str_mv 2013-11-12T11:37:48Z
2013
2013-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/10710
url http://hdl.handle.net/10362/10710
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Faculdade de Ciências e Tecnologia
publisher.none.fl_str_mv Faculdade de Ciências e Tecnologia
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833596169054322688

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