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What is the role of beta-blockers in a contemporary treatment cohort of patients with acute coronary syndrome?

Bibliographic Details
Main Author: Timóteo, Ana Teresa
Publication Date: 2018
Other Authors: Rosa, Sílvia Aguiar, Cruz, Madalena, Moreira, Rita Ilhão, Carvalho, Ramiro, Ferreira, Maria Lurdes, Ferreira, Rui Cruz
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/145058
Summary: Copyright © 2018 Sociedade Portuguesa de Cardiologia. Publicado por Elsevier España, S.L.U. All rights reserved.
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spelling What is the role of beta-blockers in a contemporary treatment cohort of patients with acute coronary syndrome?A propensity-score matching analysisBeta-blockersMyocardial infarctionPrognosisSDG 3 - Good Health and Well-beingCopyright © 2018 Sociedade Portuguesa de Cardiologia. Publicado por Elsevier España, S.L.U. All rights reserved.INTRODUCTION: The evidence for beta-blocker use in patients after acute coronary syndrome (ACS), particularly in those with left ventricular (LV) dysfunction, dates from the late 1990s. We aimed to assess the role of beta-blockers in a contemporary population of patients with ACS. METHODS: Propensity-score matching (1:2) was performed for the use of beta-blockers in a population of consecutive patients admitted to our department with ACS. After matching, 1520 patients were analyzed. Cox regression analysis was used to assess the impact of beta-blocker use on the primary outcome (one-year all-cause mortality). RESULTS: Patients who did not receive beta-blockers were less aggressively treated with other pharmacological and invasive interventions and had higher one-year mortality (20.3% vs. 7.5%). Beta-blocker use was an independent predictor of mortality, with a significant relative risk reduction of 56%. The other independent predictors were age, diabetes, LV dysfunction, heart rate, systolic blood pressure and creatinine on admission. The impact of beta-blockers was significant for all classes of LV function, including patients with normal or mildly reduced ejection fraction. CONCLUSIONS: In a contemporary ACS population, we confirmed the benefits of beta-blocker use after ACS, including in patients with normal or mildly to moderately impaired LV function.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNTimóteo, Ana TeresaRosa, Sílvia AguiarCruz, MadalenaMoreira, Rita IlhãoCarvalho, RamiroFerreira, Maria LurdesFerreira, Rui Cruz2022-10-26T22:05:06Z2018-112018-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article8application/pdfhttp://hdl.handle.net/10362/145058eng0870-2551PURE: 11115143https://doi.org/10.1016/j.repc.2017.11.016info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:06:17Zoai:run.unl.pt:10362/145058Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:36:55.657526Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv What is the role of beta-blockers in a contemporary treatment cohort of patients with acute coronary syndrome?
A propensity-score matching analysis
title What is the role of beta-blockers in a contemporary treatment cohort of patients with acute coronary syndrome?
spellingShingle What is the role of beta-blockers in a contemporary treatment cohort of patients with acute coronary syndrome?
Timóteo, Ana Teresa
Beta-blockers
Myocardial infarction
Prognosis
SDG 3 - Good Health and Well-being
title_short What is the role of beta-blockers in a contemporary treatment cohort of patients with acute coronary syndrome?
title_full What is the role of beta-blockers in a contemporary treatment cohort of patients with acute coronary syndrome?
title_fullStr What is the role of beta-blockers in a contemporary treatment cohort of patients with acute coronary syndrome?
title_full_unstemmed What is the role of beta-blockers in a contemporary treatment cohort of patients with acute coronary syndrome?
title_sort What is the role of beta-blockers in a contemporary treatment cohort of patients with acute coronary syndrome?
author Timóteo, Ana Teresa
author_facet Timóteo, Ana Teresa
Rosa, Sílvia Aguiar
Cruz, Madalena
Moreira, Rita Ilhão
Carvalho, Ramiro
Ferreira, Maria Lurdes
Ferreira, Rui Cruz
author_role author
author2 Rosa, Sílvia Aguiar
Cruz, Madalena
Moreira, Rita Ilhão
Carvalho, Ramiro
Ferreira, Maria Lurdes
Ferreira, Rui Cruz
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Timóteo, Ana Teresa
Rosa, Sílvia Aguiar
Cruz, Madalena
Moreira, Rita Ilhão
Carvalho, Ramiro
Ferreira, Maria Lurdes
Ferreira, Rui Cruz
dc.subject.por.fl_str_mv Beta-blockers
Myocardial infarction
Prognosis
SDG 3 - Good Health and Well-being
topic Beta-blockers
Myocardial infarction
Prognosis
SDG 3 - Good Health and Well-being
description Copyright © 2018 Sociedade Portuguesa de Cardiologia. Publicado por Elsevier España, S.L.U. All rights reserved.
publishDate 2018
dc.date.none.fl_str_mv 2018-11
2018-11-01T00:00:00Z
2022-10-26T22:05:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/145058
url http://hdl.handle.net/10362/145058
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0870-2551
PURE: 11115143
https://doi.org/10.1016/j.repc.2017.11.016
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 8
application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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