Cytokines and neutrophil extracellular traps in the equine endometrium: friends or foes?

Bibliographic Details
Main Author: Galvão, António
Publication Date: 2012
Other Authors: Rebordão, Maria Rosa, Szóstek, Anna Z., J. Skarzynski, Dariusz, Ferreira-Dias, Graça
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10400.5/7045
Summary: Articles in International Journals
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network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
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spelling Cytokines and neutrophil extracellular traps in the equine endometrium: friends or foes?Neutrophil extracellular trapscytokinesmareendometriumendometritisreproductionArticles in International JournalsCytokines may play a dual role in the reproductive tract – either involved in physiologic processes or mediating inflammation and other pathologic processes. Physiologic secretory and angiogenic function in the equine endometrium appears to be regulated by cytokines TNFa, FasL, IFNg through their receptors. These receptors are present in glandular epithelium, and stroma cells and their mRNA expression changes throughout the estrous cycle. Besides, interleukins (IL-1a and IL-1b) and their receptors mRNA expression vary according to various degrees of endometrium inflammation (endometritis) and fibrosis (endometrosis). A novel paradigm in innate immunity and neutrophils (PMN) hyperactivation is PMN ability to cast out their DNA in response to infectious stimuli. These PMN extracellular traps (NETs) bind and kill pathogens, at the infection site. The intriguing dilemma is that even though NETs may function as a first line of defense, they also release molecules that may contribute to tissue damage. Thus, we postulate that PMN present in the endometrium at estrus, mating or infection, might form NETs, and release nucleic and cytoplasmic proteins with immunomodulatory properties. Equine PMN stimulated in vitro showed NETs formation capacity when in contact with some bacteria strains obtained from mares with endometritis, such as Streptococcus zooepidemicus, Escherichia coli and Staphylococus capitis. In this regard, even though NETs and cytokines function as an effective antimicrobial first line of defense or modulate physiologic endometrial function, respectively (friends), they may also be involved in endometrial fibrosis pathogenesis and endometrial secretory function impairment, due to enhanced NETs formation and/or a decrease on NETs degradation (foes).PferdeheilkundeRepositório da Universidade de LisboaGalvão, AntónioRebordão, Maria RosaSzóstek, Anna Z.J. Skarzynski, DariuszFerreira-Dias, Graça2014-08-13T10:08:10Z2012-012012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/7045engGalvão, António ... [et al.]. 2012. Cytokines and neutrophil extracellular traps and in the equine endometrium: friends or foes?. Pferdeheilkunde, 28 (1):4-70177-7726info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T15:23:41Zoai:repositorio.ulisboa.pt:10400.5/7045Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:41:54.008813Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Cytokines and neutrophil extracellular traps in the equine endometrium: friends or foes?
title Cytokines and neutrophil extracellular traps in the equine endometrium: friends or foes?
spellingShingle Cytokines and neutrophil extracellular traps in the equine endometrium: friends or foes?
Galvão, António
Neutrophil extracellular traps
cytokines
mare
endometrium
endometritis
reproduction
title_short Cytokines and neutrophil extracellular traps in the equine endometrium: friends or foes?
title_full Cytokines and neutrophil extracellular traps in the equine endometrium: friends or foes?
title_fullStr Cytokines and neutrophil extracellular traps in the equine endometrium: friends or foes?
title_full_unstemmed Cytokines and neutrophil extracellular traps in the equine endometrium: friends or foes?
title_sort Cytokines and neutrophil extracellular traps in the equine endometrium: friends or foes?
author Galvão, António
author_facet Galvão, António
Rebordão, Maria Rosa
Szóstek, Anna Z.
J. Skarzynski, Dariusz
Ferreira-Dias, Graça
author_role author
author2 Rebordão, Maria Rosa
Szóstek, Anna Z.
J. Skarzynski, Dariusz
Ferreira-Dias, Graça
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Galvão, António
Rebordão, Maria Rosa
Szóstek, Anna Z.
J. Skarzynski, Dariusz
Ferreira-Dias, Graça
dc.subject.por.fl_str_mv Neutrophil extracellular traps
cytokines
mare
endometrium
endometritis
reproduction
topic Neutrophil extracellular traps
cytokines
mare
endometrium
endometritis
reproduction
description Articles in International Journals
publishDate 2012
dc.date.none.fl_str_mv 2012-01
2012-01-01T00:00:00Z
2014-08-13T10:08:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/7045
url http://hdl.handle.net/10400.5/7045
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Galvão, António ... [et al.]. 2012. Cytokines and neutrophil extracellular traps and in the equine endometrium: friends or foes?. Pferdeheilkunde, 28 (1):4-7
0177-7726
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Pferdeheilkunde
publisher.none.fl_str_mv Pferdeheilkunde
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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