The influence of atherosclerotic plaques on the pharmacokinetics of a drug eluted from bioabsorbable stents

Bibliographic Details
Main Author: Ferreira, José Augusto
Publication Date: 2017
Other Authors: Gonçalves, Lino, Naghipoor, Jahed, Oliveira, Paula de, Rabczuk, Timon
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://hdl.handle.net/10316/45373
https://doi.org/10.1016/j.mbs.2016.11.005
Summary: In this paper the effect of plaque composition, on the accumulation of drug released by a drug eluting stent, is analyzed. The mathematical model is represented by two coupled systems of partial differential equations that describe the pharmacokinetics of drug in the stent coating and in the arterial wall. The influence of the stiffness and porosity of soft and hard plaques is studied. A case study based on optical coherence tomography images is also included.
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spelling The influence of atherosclerotic plaques on the pharmacokinetics of a drug eluted from bioabsorbable stentsAbsorbable ImplantsAntineoplastic AgentsArteriesPaclitaxelPlaque, AtheroscleroticSirolimusDrug-Eluting StentsModels, TheoreticalIn this paper the effect of plaque composition, on the accumulation of drug released by a drug eluting stent, is analyzed. The mathematical model is represented by two coupled systems of partial differential equations that describe the pharmacokinetics of drug in the stent coating and in the arterial wall. The influence of the stiffness and porosity of soft and hard plaques is studied. A case study based on optical coherence tomography images is also included.Elsevier2017info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://hdl.handle.net/10316/45373https://hdl.handle.net/10316/45373https://doi.org/10.1016/j.mbs.2016.11.005https://doi.org/10.1016/j.mbs.2016.11.005enghttps://doi.org/10.1016/j.mbs.2016.11.005Ferreira, José AugustoGonçalves, LinoNaghipoor, JahedOliveira, Paula deRabczuk, Timoninfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2021-06-29T10:03:03Zoai:estudogeral.uc.pt:10316/45373Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T05:10:50.551279Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv The influence of atherosclerotic plaques on the pharmacokinetics of a drug eluted from bioabsorbable stents
title The influence of atherosclerotic plaques on the pharmacokinetics of a drug eluted from bioabsorbable stents
spellingShingle The influence of atherosclerotic plaques on the pharmacokinetics of a drug eluted from bioabsorbable stents
Ferreira, José Augusto
Absorbable Implants
Antineoplastic Agents
Arteries
Paclitaxel
Plaque, Atherosclerotic
Sirolimus
Drug-Eluting Stents
Models, Theoretical
title_short The influence of atherosclerotic plaques on the pharmacokinetics of a drug eluted from bioabsorbable stents
title_full The influence of atherosclerotic plaques on the pharmacokinetics of a drug eluted from bioabsorbable stents
title_fullStr The influence of atherosclerotic plaques on the pharmacokinetics of a drug eluted from bioabsorbable stents
title_full_unstemmed The influence of atherosclerotic plaques on the pharmacokinetics of a drug eluted from bioabsorbable stents
title_sort The influence of atherosclerotic plaques on the pharmacokinetics of a drug eluted from bioabsorbable stents
author Ferreira, José Augusto
author_facet Ferreira, José Augusto
Gonçalves, Lino
Naghipoor, Jahed
Oliveira, Paula de
Rabczuk, Timon
author_role author
author2 Gonçalves, Lino
Naghipoor, Jahed
Oliveira, Paula de
Rabczuk, Timon
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Ferreira, José Augusto
Gonçalves, Lino
Naghipoor, Jahed
Oliveira, Paula de
Rabczuk, Timon
dc.subject.por.fl_str_mv Absorbable Implants
Antineoplastic Agents
Arteries
Paclitaxel
Plaque, Atherosclerotic
Sirolimus
Drug-Eluting Stents
Models, Theoretical
topic Absorbable Implants
Antineoplastic Agents
Arteries
Paclitaxel
Plaque, Atherosclerotic
Sirolimus
Drug-Eluting Stents
Models, Theoretical
description In this paper the effect of plaque composition, on the accumulation of drug released by a drug eluting stent, is analyzed. The mathematical model is represented by two coupled systems of partial differential equations that describe the pharmacokinetics of drug in the stent coating and in the arterial wall. The influence of the stiffness and porosity of soft and hard plaques is studied. A case study based on optical coherence tomography images is also included.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10316/45373
https://hdl.handle.net/10316/45373
https://doi.org/10.1016/j.mbs.2016.11.005
https://doi.org/10.1016/j.mbs.2016.11.005
url https://hdl.handle.net/10316/45373
https://doi.org/10.1016/j.mbs.2016.11.005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://doi.org/10.1016/j.mbs.2016.11.005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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