Systemic lupus erythematosus features in rheumatoid arthritis and their effect on overall mortality

Detalhes bibliográficos
Autor(a) principal: Icen, Murat
Data de Publicação: 2008
Outros Autores: Nicola, Paulo J., Maradit-Kremers, Hilal, Crowson, Cynthia S., Therneau, Terry M., Matteson, Eric L., Gabriel, Sherine E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://hdl.handle.net/10451/23331
Resumo: Copyright © 2009 The Journal of Rheumatology. All rights reserved.
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spelling Systemic lupus erythematosus features in rheumatoid arthritis and their effect on overall mortalityRheumatoid arthritisSystemic lupus erythematosusMortalityCopyright © 2009 The Journal of Rheumatology. All rights reserved.Objective. Features of systemic lupus erythematosus (SLE) are commonly observed in patients with rheumatoid arthritis (RA). However, their frequency and clinical significance are uncertain. We examined the frequency of SLE features in RA and their effect on overall mortality. Methods. We assembled a population-based incidence cohort of subjects aged ≥ 18 years first diagnosed with RA [1987 American College of Rheumatology (ACR) criteria] between 1955 and 1995. Information regarding disease characteristics, therapy, comorbidities, and SLE features (1982 ACR criteria) were collected from the complete inpatient and outpatient medical records. Cox regression models were used to estimate the mortality risk associated with lupus features. Results. The study population comprised 603 subjects with incident RA (mean age 58 yrs, 73% women) with a mean followup time of 15 years. By 25 years after RA incidence, ≥ 4 SLE features were observed in 15.5% of the subjects with RA. After adjustment for age and sex, occurrence of ≥ 4 SLE features was associated with increased overall mortality [hazard ratio (HR) 5.54, 95% confidence interval (CI) 3.59–8.53].With further adjustment for RA characteristics, therapy, and comorbidities, the association weakened but remained statistically significant (HR 2.56, 95% CI 1.60–4.08). After adjustment for age, sex, RA characteristics, therapy, and comorbidities, thrombocytopenia (2.0, 95% CI 1.2, 3.1) and proteinuria (1.8, 95% CI 1.3, 2.6) were significantly associated with mortality. Conclusion. SLE features were common in RA, given sufficient observation time. Subjects with RA who developed ≥ 4 SLE features had an increased risk of death. Proteinuria and thrombocytopenia were individually associated with an increased mortality risk.Supported in part by a grant from the National Institutes of Health, NIAMS (R01 AR46849), and the National Institutes of Health (AR-30582) US Public Health Service. Dr. Nicola was funded by a fellowship from the Fundação para a Ciência e Tecnologia, Portugal (SFRH/BD/17282/2004)Earl D. SilvermanRepositório da Universidade de LisboaIcen, MuratNicola, Paulo J.Maradit-Kremers, HilalCrowson, Cynthia S.Therneau, Terry M.Matteson, Eric L.Gabriel, Sherine E.2016-04-07T15:45:30Z20082008-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/23331engJ Rheumatol 2009;36:50–570315-162X10.3899/jrheum.080091metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T13:28:07Zoai:repositorio.ulisboa.pt:10451/23331Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T02:45:14.717867Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Systemic lupus erythematosus features in rheumatoid arthritis and their effect on overall mortality
title Systemic lupus erythematosus features in rheumatoid arthritis and their effect on overall mortality
spellingShingle Systemic lupus erythematosus features in rheumatoid arthritis and their effect on overall mortality
Icen, Murat
Rheumatoid arthritis
Systemic lupus erythematosus
Mortality
title_short Systemic lupus erythematosus features in rheumatoid arthritis and their effect on overall mortality
title_full Systemic lupus erythematosus features in rheumatoid arthritis and their effect on overall mortality
title_fullStr Systemic lupus erythematosus features in rheumatoid arthritis and their effect on overall mortality
title_full_unstemmed Systemic lupus erythematosus features in rheumatoid arthritis and their effect on overall mortality
title_sort Systemic lupus erythematosus features in rheumatoid arthritis and their effect on overall mortality
author Icen, Murat
author_facet Icen, Murat
Nicola, Paulo J.
Maradit-Kremers, Hilal
Crowson, Cynthia S.
Therneau, Terry M.
Matteson, Eric L.
Gabriel, Sherine E.
author_role author
author2 Nicola, Paulo J.
Maradit-Kremers, Hilal
Crowson, Cynthia S.
Therneau, Terry M.
Matteson, Eric L.
Gabriel, Sherine E.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Icen, Murat
Nicola, Paulo J.
Maradit-Kremers, Hilal
Crowson, Cynthia S.
Therneau, Terry M.
Matteson, Eric L.
Gabriel, Sherine E.
dc.subject.por.fl_str_mv Rheumatoid arthritis
Systemic lupus erythematosus
Mortality
topic Rheumatoid arthritis
Systemic lupus erythematosus
Mortality
description Copyright © 2009 The Journal of Rheumatology. All rights reserved.
publishDate 2008
dc.date.none.fl_str_mv 2008
2008-01-01T00:00:00Z
2016-04-07T15:45:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/23331
url http://hdl.handle.net/10451/23331
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Rheumatol 2009;36:50–57
0315-162X
10.3899/jrheum.080091
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Earl D. Silverman
publisher.none.fl_str_mv Earl D. Silverman
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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