Predictors of functional capacity in patients with pulmonary hypertension

Bibliographic Details
Main Author: Plácido, Rui
Publication Date: 2015
Other Authors: Martins, Susana, Marques, João Silva, Kovell, Lara, Gonçalves, Susana, Almeida, Ana G., Diogo, António Nunes, Pinto, Fausto J.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/34242
Summary: © 2015 Plácido R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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spelling Predictors of functional capacity in patients with pulmonary hypertensionPulmonary hypertension6-Minute walk testBiomarkersEchocardiographyPrognosis© 2015 Plácido R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Introduction: The 6-minute walk test (6 MWT) distance is frequently used in the prediction of pulmonary hypertension (PH) prognosis. However, potential surrogates of this measure have not been established. We aim to describe the clinical, echocardiographic, and laboratorial criteria determining the 6 MWT distance in patients with PH. Methods: In 22 consecutive PH patients, functional capacity was evaluated by the 6 MWT distance and compared with levels of neurohormonal activation biomarkers and echocardiographic parameters for right ventricular (RV) function. Results: A correlation between the 6 MWT distance and several clinical parameters was found: Borg’s pre-test classification (R=-0.46; p=0.038); WHO functional class (p=0.029). Patients with higher levels of aldosterone (R=-0.46; p=0.030), renin (R=-0.43; p=0.046) and mid-regional pro-adrenomedullin (MR-proADM, R=-0.53; p=0.009) had worse 6 MWT performance. The opposite was true for natremia levels (R=0.55; p=0.006). There was a positive correlation between the 6 MWT distance and RV global longitudinal peak systolic strain rate and early diastolic strain rate (R=0.49; p=0.038 and R=-0.55; p=0.018, respectively). On multivariate analysis, only natremia and early diastolic strain rate were predictors of the 6 MWT distance. Conclusion: The 6 MWT distance correlated with renin-angiotensin-aldosterone system activation and parameters for RV myocardial deformation. The new biomarker MR-proADM proved to be useful in the prediction of the functional capacity.OMICS InternationalRepositório da Universidade de LisboaPlácido, RuiMartins, SusanaMarques, João SilvaKovell, LaraGonçalves, SusanaAlmeida, Ana G.Diogo, António NunesPinto, Fausto J.2018-07-18T14:53:50Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/34242engJ Pulm Respir Med 5: 2902161-105X10.4172/2161-105X.1000290info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T13:56:17Zoai:repositorio.ulisboa.pt:10451/34242Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T02:58:38.698355Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Predictors of functional capacity in patients with pulmonary hypertension
title Predictors of functional capacity in patients with pulmonary hypertension
spellingShingle Predictors of functional capacity in patients with pulmonary hypertension
Plácido, Rui
Pulmonary hypertension
6-Minute walk test
Biomarkers
Echocardiography
Prognosis
title_short Predictors of functional capacity in patients with pulmonary hypertension
title_full Predictors of functional capacity in patients with pulmonary hypertension
title_fullStr Predictors of functional capacity in patients with pulmonary hypertension
title_full_unstemmed Predictors of functional capacity in patients with pulmonary hypertension
title_sort Predictors of functional capacity in patients with pulmonary hypertension
author Plácido, Rui
author_facet Plácido, Rui
Martins, Susana
Marques, João Silva
Kovell, Lara
Gonçalves, Susana
Almeida, Ana G.
Diogo, António Nunes
Pinto, Fausto J.
author_role author
author2 Martins, Susana
Marques, João Silva
Kovell, Lara
Gonçalves, Susana
Almeida, Ana G.
Diogo, António Nunes
Pinto, Fausto J.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Plácido, Rui
Martins, Susana
Marques, João Silva
Kovell, Lara
Gonçalves, Susana
Almeida, Ana G.
Diogo, António Nunes
Pinto, Fausto J.
dc.subject.por.fl_str_mv Pulmonary hypertension
6-Minute walk test
Biomarkers
Echocardiography
Prognosis
topic Pulmonary hypertension
6-Minute walk test
Biomarkers
Echocardiography
Prognosis
description © 2015 Plácido R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
2018-07-18T14:53:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/34242
url http://hdl.handle.net/10451/34242
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Pulm Respir Med 5: 290
2161-105X
10.4172/2161-105X.1000290
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv OMICS International
publisher.none.fl_str_mv OMICS International
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833601549516931072

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