Adenosine receptors are the on‐and‐off switch of astrocytic cannabinoid type 1 (CB1) receptor effect upon synaptic plasticity in the medial prefrontal cortex

Bibliographic Details
Main Author: Gonçalves-Ribeiro, Joana
Publication Date: 2024
Other Authors: Savchak, Oksana K., Pinto, Sara, Gomes, Joana I., Rivas‐Santisteban, Rafael, Lillo, Alejandro, Sánchez Romero, Javier, Sebastião, Ana M, Navarrete, Marta, Navarro, Gemma, Franco, Rafael, Vaz, Sandra H.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/64145
Summary: © 2024 The Authors. GLIA published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
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spelling Adenosine receptors are the on‐and‐off switch of astrocytic cannabinoid type 1 (CB1) receptor effect upon synaptic plasticity in the medial prefrontal cortexCB1 receptorAdenosine receptorsAstrogliamPFCSynaptic plasticity© 2024 The Authors. GLIA published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.The medial prefrontal cortex (mPFC) is involved in cognitive functions such as working memory. Astrocytic cannabinoid type 1 receptor (CB1R) induces cytosolic calcium (Ca2+) concentration changes with an impact on neuronal function. mPFC astrocytes also express adenosine A1 and A2A receptors (A1R, A2AR), being unknown the crosstalk between CB1R and adenosine receptors in these cells. We show here that a further level of regulation of astrocyte Ca2+ signaling occurs through CB1R-A2AR or CB1R-A1R heteromers that ultimately impact mPFC synaptic plasticity. CB1R-mediated Ca2+ transients increased and decreased when A1R and A2AR were activated, respectively, unveiling adenosine receptors as modulators of astrocytic CB1R. CB1R activation leads to an enhancement of long-term potentiation (LTP) in the mPFC, under the control of A1R but not of A2AR. Notably, in IP3R2KO mice, that do not show astrocytic Ca2+ level elevations, CB1R activation decreases LTP, which is not modified by A1R or A2AR. The present work suggests that CB1R has a homeostatic role on mPFC LTP, under the control of A1R, probably due to physical crosstalk between these receptors in astrocytes that ultimately alters CB1R Ca2+ signaling.This work was supported by the Fundaçao para a Ciência e para a Tecnologia (FCT) (grant PTDC/MED-FAR/30933/2017 to AMS, PD/BD/150342/2019 to JG-R and SFRH/BD/147277/2019 to SC-P), by the International Society for Neurochemistry (Carer Development Grant 2021 to SHV), the European Union (H2020-WIDESPREAD-05-2017-Twinning (EpiEpinet), grant agreement 952455, to AMS and SHV), the Spanish Ministry for Science, Innovation and Universities (MCIN/AEI/10.13039/501100011033) and the “ERDF A way of making Europe” (grant PID2021-122586NB-I00 to MN and PID2021-126600OB-I00 to RF), and the Fundación Tatiana Pérez de Guzmán el Bueno (PhD grant to JSR).WileyRepositório da Universidade de LisboaGonçalves-Ribeiro, JoanaSavchak, Oksana K.Pinto, SaraGomes, Joana I.Rivas‐Santisteban, RafaelLillo, AlejandroSánchez Romero, JavierSebastião, Ana MNavarrete, MartaNavarro, GemmaFranco, RafaelVaz, Sandra H.2024-04-11T13:18:46Z20242024-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/64145engGlia. 2024 Jun;72(6):1096-11160894-149110.1002/glia.245181098-1136info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T15:14:11Zoai:repositorio.ulisboa.pt:10451/64145Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:37:37.135737Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Adenosine receptors are the on‐and‐off switch of astrocytic cannabinoid type 1 (CB1) receptor effect upon synaptic plasticity in the medial prefrontal cortex
title Adenosine receptors are the on‐and‐off switch of astrocytic cannabinoid type 1 (CB1) receptor effect upon synaptic plasticity in the medial prefrontal cortex
spellingShingle Adenosine receptors are the on‐and‐off switch of astrocytic cannabinoid type 1 (CB1) receptor effect upon synaptic plasticity in the medial prefrontal cortex
Gonçalves-Ribeiro, Joana
CB1 receptor
Adenosine receptors
Astroglia
mPFC
Synaptic plasticity
title_short Adenosine receptors are the on‐and‐off switch of astrocytic cannabinoid type 1 (CB1) receptor effect upon synaptic plasticity in the medial prefrontal cortex
title_full Adenosine receptors are the on‐and‐off switch of astrocytic cannabinoid type 1 (CB1) receptor effect upon synaptic plasticity in the medial prefrontal cortex
title_fullStr Adenosine receptors are the on‐and‐off switch of astrocytic cannabinoid type 1 (CB1) receptor effect upon synaptic plasticity in the medial prefrontal cortex
title_full_unstemmed Adenosine receptors are the on‐and‐off switch of astrocytic cannabinoid type 1 (CB1) receptor effect upon synaptic plasticity in the medial prefrontal cortex
title_sort Adenosine receptors are the on‐and‐off switch of astrocytic cannabinoid type 1 (CB1) receptor effect upon synaptic plasticity in the medial prefrontal cortex
author Gonçalves-Ribeiro, Joana
author_facet Gonçalves-Ribeiro, Joana
Savchak, Oksana K.
Pinto, Sara
Gomes, Joana I.
Rivas‐Santisteban, Rafael
Lillo, Alejandro
Sánchez Romero, Javier
Sebastião, Ana M
Navarrete, Marta
Navarro, Gemma
Franco, Rafael
Vaz, Sandra H.
author_role author
author2 Savchak, Oksana K.
Pinto, Sara
Gomes, Joana I.
Rivas‐Santisteban, Rafael
Lillo, Alejandro
Sánchez Romero, Javier
Sebastião, Ana M
Navarrete, Marta
Navarro, Gemma
Franco, Rafael
Vaz, Sandra H.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Gonçalves-Ribeiro, Joana
Savchak, Oksana K.
Pinto, Sara
Gomes, Joana I.
Rivas‐Santisteban, Rafael
Lillo, Alejandro
Sánchez Romero, Javier
Sebastião, Ana M
Navarrete, Marta
Navarro, Gemma
Franco, Rafael
Vaz, Sandra H.
dc.subject.por.fl_str_mv CB1 receptor
Adenosine receptors
Astroglia
mPFC
Synaptic plasticity
topic CB1 receptor
Adenosine receptors
Astroglia
mPFC
Synaptic plasticity
description © 2024 The Authors. GLIA published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
publishDate 2024
dc.date.none.fl_str_mv 2024-04-11T13:18:46Z
2024
2024-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/64145
url http://hdl.handle.net/10451/64145
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Glia. 2024 Jun;72(6):1096-1116
0894-1491
10.1002/glia.24518
1098-1136
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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