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Renin-angiotensin system in lung tumor and microenvironment interactions

Bibliographic Details
Main Author: Catarata, MJ
Publication Date: 2020
Other Authors: Ribeiro, R, Oliveira, MJ, Cordeiro, CR, Medeiros, R
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://hdl.handle.net/10216/143500
Summary: The mechanistic involvement of the renin-angiotensin system (RAS) reaches beyond cardiovascular physiopathology. Recent knowledge pinpoints a pleiotropic role for this system, particularly in the lung, and mainly through locally regulated alternative molecules and secondary pathways. Angiotensin peptides play a role in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. This manuscript reviews the literature supporting a role for the renin-angiotensin system in the lung tumor microenvironment and discusses whether blockade of this pathway in clinical settings may serve as an adjuvant therapy in lung cancer.
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spelling Renin-angiotensin system in lung tumor and microenvironment interactionsHypoxiaLung cancerRenin-angiotensinTumor microenvironmentThe mechanistic involvement of the renin-angiotensin system (RAS) reaches beyond cardiovascular physiopathology. Recent knowledge pinpoints a pleiotropic role for this system, particularly in the lung, and mainly through locally regulated alternative molecules and secondary pathways. Angiotensin peptides play a role in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. This manuscript reviews the literature supporting a role for the renin-angiotensin system in the lung tumor microenvironment and discusses whether blockade of this pathway in clinical settings may serve as an adjuvant therapy in lung cancer.MDPI20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/143500eng2072-669410.3390/cancers12061457Catarata, MJRibeiro, ROliveira, MJCordeiro, CRMedeiros, Rinfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-02-27T17:16:17Zoai:repositorio-aberto.up.pt:10216/143500Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T22:08:40.701997Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Renin-angiotensin system in lung tumor and microenvironment interactions
title Renin-angiotensin system in lung tumor and microenvironment interactions
spellingShingle Renin-angiotensin system in lung tumor and microenvironment interactions
Catarata, MJ
Hypoxia
Lung cancer
Renin-angiotensin
Tumor microenvironment
title_short Renin-angiotensin system in lung tumor and microenvironment interactions
title_full Renin-angiotensin system in lung tumor and microenvironment interactions
title_fullStr Renin-angiotensin system in lung tumor and microenvironment interactions
title_full_unstemmed Renin-angiotensin system in lung tumor and microenvironment interactions
title_sort Renin-angiotensin system in lung tumor and microenvironment interactions
author Catarata, MJ
author_facet Catarata, MJ
Ribeiro, R
Oliveira, MJ
Cordeiro, CR
Medeiros, R
author_role author
author2 Ribeiro, R
Oliveira, MJ
Cordeiro, CR
Medeiros, R
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Catarata, MJ
Ribeiro, R
Oliveira, MJ
Cordeiro, CR
Medeiros, R
dc.subject.por.fl_str_mv Hypoxia
Lung cancer
Renin-angiotensin
Tumor microenvironment
topic Hypoxia
Lung cancer
Renin-angiotensin
Tumor microenvironment
description The mechanistic involvement of the renin-angiotensin system (RAS) reaches beyond cardiovascular physiopathology. Recent knowledge pinpoints a pleiotropic role for this system, particularly in the lung, and mainly through locally regulated alternative molecules and secondary pathways. Angiotensin peptides play a role in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. This manuscript reviews the literature supporting a role for the renin-angiotensin system in the lung tumor microenvironment and discusses whether blockade of this pathway in clinical settings may serve as an adjuvant therapy in lung cancer.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/143500
url https://hdl.handle.net/10216/143500
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2072-6694
10.3390/cancers12061457
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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