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Cell-penetrating peptides: a tool for effective delivery in gene-targeted therapies

Bibliographic Details
Main Author: Figueiredo, Inês Rego de
Publication Date: 2014
Other Authors: Freire, João Miguel, Flores, Luís, Veiga, Ana Salomé, Castanho, Miguel A. R. B.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/23253
Summary: © 2014 International Union of Biochemistry and Molecular Biology
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spelling Cell-penetrating peptides: a tool for effective delivery in gene-targeted therapiesCell-penetrating peptideGene therapyCancer treatmentDrug delivery© 2014 International Union of Biochemistry and Molecular BiologyThe current landscapes of novel therapeutic approaches rely mostly on gene-targeted technologies, enabling to fight rare genomic diseases, from infections to cancer and hereditary diseases. Although, reaching the action-site for this novel treatments requires to deliver nucleic acids, or other macromolecules into cells, which may pose difficult tasks to pharmaceutical companies. To overcome this technological limitation, a wide variety of vectors have been developed in the past decades and have proven to be successful in delivering various therapeutics. Cell-penetrating peptides (CPP) have been one of the technologies widely studied and have been increasingly used to transport small RNA/DNA, plasmids, antibodies, and nanoparticles into cells. Despite the already proved huge potential that these peptide-based approaches may suggest, few advances have been put to pharmacological or clinical use. This review will describe the origin, development, and usage of CPP to deliver therapeutic agents into cells, with special emphasis on their current application to gene-therapies. Specifically, we will describe the current trials being conducted to treat cancer, gene disorders, and autoimmune diseases using CPP-based therapies.The authors thank Fundação para a Ciência e Tecnologia–Ministério da Educação e Ciência (FCT-MEC, Portugal) [PTDC/QUIBIQ/112929/2009] and Gabinete de Apoio à Investigação Científica, Tecnológica e Inovação (GAPIC–20130028/PEC/BG, 20120006, and 20110007). JMF acknowledges FCT-MEC for fellowship SFRH/BD/70423/2010WileyRepositório da Universidade de LisboaFigueiredo, Inês Rego deFreire, João MiguelFlores, LuísVeiga, Ana SaloméCastanho, Miguel A. R. B.2016-04-05T15:52:28Z20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/23253eng2014 International Union of Biochemistry and Molecular Biology, Volume 66, Number 3, March 2014, Pages 182–1941521-6543DOI 10.1002/iub.1257metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T13:28:03Zoai:repositorio.ulisboa.pt:10451/23253Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T02:45:13.482383Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Cell-penetrating peptides: a tool for effective delivery in gene-targeted therapies
title Cell-penetrating peptides: a tool for effective delivery in gene-targeted therapies
spellingShingle Cell-penetrating peptides: a tool for effective delivery in gene-targeted therapies
Figueiredo, Inês Rego de
Cell-penetrating peptide
Gene therapy
Cancer treatment
Drug delivery
title_short Cell-penetrating peptides: a tool for effective delivery in gene-targeted therapies
title_full Cell-penetrating peptides: a tool for effective delivery in gene-targeted therapies
title_fullStr Cell-penetrating peptides: a tool for effective delivery in gene-targeted therapies
title_full_unstemmed Cell-penetrating peptides: a tool for effective delivery in gene-targeted therapies
title_sort Cell-penetrating peptides: a tool for effective delivery in gene-targeted therapies
author Figueiredo, Inês Rego de
author_facet Figueiredo, Inês Rego de
Freire, João Miguel
Flores, Luís
Veiga, Ana Salomé
Castanho, Miguel A. R. B.
author_role author
author2 Freire, João Miguel
Flores, Luís
Veiga, Ana Salomé
Castanho, Miguel A. R. B.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Figueiredo, Inês Rego de
Freire, João Miguel
Flores, Luís
Veiga, Ana Salomé
Castanho, Miguel A. R. B.
dc.subject.por.fl_str_mv Cell-penetrating peptide
Gene therapy
Cancer treatment
Drug delivery
topic Cell-penetrating peptide
Gene therapy
Cancer treatment
Drug delivery
description © 2014 International Union of Biochemistry and Molecular Biology
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01T00:00:00Z
2016-04-05T15:52:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/23253
url http://hdl.handle.net/10451/23253
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2014 International Union of Biochemistry and Molecular Biology, Volume 66, Number 3, March 2014, Pages 182–194
1521-6543
DOI 10.1002/iub.1257
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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