Synergistic antimicrobial interaction between honey and phage against Escherichia coli biofilms

Bibliographic Details
Main Author: Oliveira, A.
Publication Date: 2017
Other Authors: Ribeiro, Henrique, Silva, A., Silva, Maria Daniela, Sousa, J., Rodrigues, Célia Fortuna, Melo, Luís D. R., Henriques, Ana Filipa, Sillankorva, Sanna
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/1822/47098
Summary: CEB Annual Meeting 2017
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spelling Synergistic antimicrobial interaction between honey and phage against Escherichia coli biofilmsAntimicrobialHneyPhageEscherichia coliBiofilmsCEB Annual Meeting 2017Chronic wounds that take months, years or may even never heal present a major biological and financial problem on both individual patients and the broader health system. Chronic wounds afford a hostile environment of damaged tissues that allow bacterial proliferation and further wound colonization. Wound colonization by bacterial biofilms is one of the main obstacles of chronic wounds healing. Biofilms are structured communities of bacterial cells enclosed in a self-produced polymeric matrix and adhered to an inert or living surface. Escherichia coli is among the most common colonizers of infected wounds and it is a prolific biofilm former. Living in biofilm communities, cells are protected, become more difficult to control and eradicate, and less susceptible to antibiotic therapy. Due to the vast increase of antibiotic resistant bacteria, there is a renewed interestin pre-antibiotic therapies. Years before the discovery of modern antibiotics, bacteriophages(phages) that are bacterial viruses, and beehive products such as honey were extensively used for their antimicrobial properties. Phages, are the natural bacterial enemies and have proven efficacy towards antibiotic-resistant bacteria, have self-replicating nature, do not interfere with the commensal flora and many studies acknowledge that phages can destroy, tovarying extent, mono and mixed biofilm populations. Honey, on the other hand, has a broad spectrum antibacterial activity against bacteria and its high viscosity provides a protective barrier against infections being suitable for skincare, promoting the wound healing, tissue regeneration and anti-inflammatory process. This work presents insights into the proceedings triggering E.coli biofilm control with phage, two Portuguese(PT) honeys and their combination, achieved through standard antimicrobial activity assays, zeta potential and flow cytometry studies and further visual insights sought by SEM and TEM microscopy.This study was supported by FCT under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI-01-0145-FEDER-006684) and BioTecNorteoperation (NORTE-01-0145-FEDER-000004) funded by the European Regional Development Fund under the scope of Norte2020 - Programa Operacional Regional do Norte.info:eu-repo/semantics/publishedVersionUniversidade do MinhoOliveira, A.Ribeiro, HenriqueSilva, A.Silva, Maria DanielaSousa, J.Rodrigues, Célia FortunaMelo, Luís D. R.Henriques, Ana FilipaSillankorva, Sanna2017-07-062017-07-06T00:00:00Zconference posterinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/1822/47098engOliveira, A.; Ribeiro, Henrique; Silva, A.; Silva, Maria Daniela; Sousa, J.; Rodrigues, Célia F.; Melo, Luís D. R.; Henriques, Ana Filipa; Sillankorva, Sanna, Synergistic antimicrobial interaction between honey and phage against Escherichia coli biofilms. CEB Annual Meeting 2017. Braga, Portugal, 6th July, 2017.info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-11T05:43:24Zoai:repositorium.sdum.uminho.pt:1822/47098Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T15:27:48.109486Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Synergistic antimicrobial interaction between honey and phage against Escherichia coli biofilms
title Synergistic antimicrobial interaction between honey and phage against Escherichia coli biofilms
spellingShingle Synergistic antimicrobial interaction between honey and phage against Escherichia coli biofilms
Oliveira, A.
Antimicrobial
Hney
Phage
Escherichia coli
Biofilms
title_short Synergistic antimicrobial interaction between honey and phage against Escherichia coli biofilms
title_full Synergistic antimicrobial interaction between honey and phage against Escherichia coli biofilms
title_fullStr Synergistic antimicrobial interaction between honey and phage against Escherichia coli biofilms
title_full_unstemmed Synergistic antimicrobial interaction between honey and phage against Escherichia coli biofilms
title_sort Synergistic antimicrobial interaction between honey and phage against Escherichia coli biofilms
author Oliveira, A.
author_facet Oliveira, A.
Ribeiro, Henrique
Silva, A.
Silva, Maria Daniela
Sousa, J.
Rodrigues, Célia Fortuna
Melo, Luís D. R.
Henriques, Ana Filipa
Sillankorva, Sanna
author_role author
author2 Ribeiro, Henrique
Silva, A.
Silva, Maria Daniela
Sousa, J.
Rodrigues, Célia Fortuna
Melo, Luís D. R.
Henriques, Ana Filipa
Sillankorva, Sanna
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Oliveira, A.
Ribeiro, Henrique
Silva, A.
Silva, Maria Daniela
Sousa, J.
Rodrigues, Célia Fortuna
Melo, Luís D. R.
Henriques, Ana Filipa
Sillankorva, Sanna
dc.subject.por.fl_str_mv Antimicrobial
Hney
Phage
Escherichia coli
Biofilms
topic Antimicrobial
Hney
Phage
Escherichia coli
Biofilms
description CEB Annual Meeting 2017
publishDate 2017
dc.date.none.fl_str_mv 2017-07-06
2017-07-06T00:00:00Z
dc.type.driver.fl_str_mv conference poster
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/47098
url http://hdl.handle.net/1822/47098
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Oliveira, A.; Ribeiro, Henrique; Silva, A.; Silva, Maria Daniela; Sousa, J.; Rodrigues, Célia F.; Melo, Luís D. R.; Henriques, Ana Filipa; Sillankorva, Sanna, Synergistic antimicrobial interaction between honey and phage against Escherichia coli biofilms. CEB Annual Meeting 2017. Braga, Portugal, 6th July, 2017.
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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