Fe3O4-Au core-shell nanoparticles as a multimodal platform for in vivo imaging and focused photothermal therapy
| Main Author: | |
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| Publication Date: | 2021 |
| Other Authors: | , , , , , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Download full: | http://hdl.handle.net/10362/132549 |
Summary: | CTQ2017-86655-R BIO2017-84246-C2-1-R |
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Fe3O4-Au core-shell nanoparticles as a multimodal platform for in vivo imaging and focused photothermal therapyContrast agentCTImaging-guided therapyMRIMultimodal imagingPharmaceutical ScienceCTQ2017-86655-R BIO2017-84246-C2-1-RIn this study, we report the synthesis of gold-coated iron oxide nanoparticles capped with polyvinylpyrrolidone (Fe@Au NPs). The as-synthesized nanoparticles (NPs) exhibited good stability in aqueous media and excellent features as contrast agents (CA) for both magnetic resonance imaging (MRI) and X-ray computed tomography (CT). Additionally, due to the presence of the local surface plasmon resonances of gold, the NPs showed exploitable “light-to-heat” conversion ability in the near-infrared (NIR) region, a key attribute for effective photothermal therapies (PTT). In vitro experiments revealed biocompatibility as well as excellent efficiency in killing glioblastoma cells via PTT. The in vivo nontoxicity of the NPs was demonstrated using zebrafish embryos as an intermediate step between cells and rodent models. To warrant that an effective therapeutic dose was achieved inside the tumor, both intratumoral and intravenous routes were screened in rodent models by MRI and CT. The pharmacokinetics and biodistribution confirmed the multimodal imaging CA capabilities of the Fe@AuNPs and revealed constraints of the intravenous route for tumor targeting, dictating intratumoral administration for therapeutic applications. Finally, Fe@Au NPs were successfully used for an in vivo proof of concept of imaging- guided focused PTT against glioblastoma multiforme in a mouse model.UCIBIO - Applied Molecular Biosciences UnitDQ - Departamento de QuímicaRUNCaro, CarlosGámez, FranciscoQuaresma, PedroPáez-Muñoz, Jose MaríaDomínguez, AlejandroPearson, John R.Pernía Leal, ManuelBeltrán, Ana M.Fernandez-Afonso, YilianDe La Fuente, Jesús M.Franco, RicardoPereira, EuláliaGarcía-Martín, Maria Luisa2022-02-08T23:23:29Z2021-03-202021-03-20T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/132549eng1999-4923PURE: 36680595https://doi.org/10.3390/pharmaceutics13030416info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:59:14Zoai:run.unl.pt:10362/132549Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:30:21.101848Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
Fe3O4-Au core-shell nanoparticles as a multimodal platform for in vivo imaging and focused photothermal therapy |
| title |
Fe3O4-Au core-shell nanoparticles as a multimodal platform for in vivo imaging and focused photothermal therapy |
| spellingShingle |
Fe3O4-Au core-shell nanoparticles as a multimodal platform for in vivo imaging and focused photothermal therapy Caro, Carlos Contrast agent CT Imaging-guided therapy MRI Multimodal imaging Pharmaceutical Science |
| title_short |
Fe3O4-Au core-shell nanoparticles as a multimodal platform for in vivo imaging and focused photothermal therapy |
| title_full |
Fe3O4-Au core-shell nanoparticles as a multimodal platform for in vivo imaging and focused photothermal therapy |
| title_fullStr |
Fe3O4-Au core-shell nanoparticles as a multimodal platform for in vivo imaging and focused photothermal therapy |
| title_full_unstemmed |
Fe3O4-Au core-shell nanoparticles as a multimodal platform for in vivo imaging and focused photothermal therapy |
| title_sort |
Fe3O4-Au core-shell nanoparticles as a multimodal platform for in vivo imaging and focused photothermal therapy |
| author |
Caro, Carlos |
| author_facet |
Caro, Carlos Gámez, Francisco Quaresma, Pedro Páez-Muñoz, Jose María Domínguez, Alejandro Pearson, John R. Pernía Leal, Manuel Beltrán, Ana M. Fernandez-Afonso, Yilian De La Fuente, Jesús M. Franco, Ricardo Pereira, Eulália García-Martín, Maria Luisa |
| author_role |
author |
| author2 |
Gámez, Francisco Quaresma, Pedro Páez-Muñoz, Jose María Domínguez, Alejandro Pearson, John R. Pernía Leal, Manuel Beltrán, Ana M. Fernandez-Afonso, Yilian De La Fuente, Jesús M. Franco, Ricardo Pereira, Eulália García-Martín, Maria Luisa |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
UCIBIO - Applied Molecular Biosciences Unit DQ - Departamento de Química RUN |
| dc.contributor.author.fl_str_mv |
Caro, Carlos Gámez, Francisco Quaresma, Pedro Páez-Muñoz, Jose María Domínguez, Alejandro Pearson, John R. Pernía Leal, Manuel Beltrán, Ana M. Fernandez-Afonso, Yilian De La Fuente, Jesús M. Franco, Ricardo Pereira, Eulália García-Martín, Maria Luisa |
| dc.subject.por.fl_str_mv |
Contrast agent CT Imaging-guided therapy MRI Multimodal imaging Pharmaceutical Science |
| topic |
Contrast agent CT Imaging-guided therapy MRI Multimodal imaging Pharmaceutical Science |
| description |
CTQ2017-86655-R BIO2017-84246-C2-1-R |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-03-20 2021-03-20T00:00:00Z 2022-02-08T23:23:29Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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http://hdl.handle.net/10362/132549 |
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eng |
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eng |
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1999-4923 PURE: 36680595 https://doi.org/10.3390/pharmaceutics13030416 |
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