Hypoalbuminaemia and one-year mortality in haemodialysis patients with heart failure: a cohort analysis

Bibliographic Details
Main Author: Cardoso, Ana
Publication Date: 2021
Other Authors: Branco, Carolina, Sant’Ana, Mariana, Costa, Cláudia, Marques Da Silva, Bernardo, Agapito Fonseca, José, Outerelo, Cristina, Gameiro, Joana
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/59788
Summary: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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spelling Hypoalbuminaemia and one-year mortality in haemodialysis patients with heart failure: a cohort analysisChronic haemodialysisHeart failureHypoalbuminaemiaMalnutritionMortality© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Introduction: The prevalence of chronic kidney disease (CKD) and heart failure (HF) has been rising over the past decade, with a prevalence close to 40%. Cardiovascular disease and malnutrition are common comorbidities and known risk factors for mortality in haemodialysis (HD) patients. We aimed to evaluate the one-year mortality rate after dialysis induction, and the impact of serum albumin levels on survival outcomes, in patients with CKD and HF. Methods: This was a retrospective analysis of patients with CKD and HF who underwent chronic HD between January 2016 and December 2019 in a tertiary-care Portuguese hospital. Variables were submitted to univariate and multivariate analysis to determine factors predictive of one-mortality after HD start. Results: In total, 204 patients were analysed (mean age 75.1 ± 10.3 years). Within the first year of HD start, 28.7% of patients died. These patients were significantly older [79.8 ± 7.2 versus 72.9 ± 10.9 years, p < 0.001; OR 1.08 (1.04-1.13), p < 0.001] and had a higher mean Charlson Index [9.0 ± 1.8 versus 8.3 ± 2.0, p = 0.015; OR 1.22 (1.04-1.44), p = 0.017], lower serum creatinine [5.1 ± 1.6 mg/dL versus 5.8 ± 2.0 mg/dL; p = 0.021; OR 0.80 (0.65-0.97), p = 0.022], lower albumin levels [3.1 ± 0.6 g/dL versus 3.4 ± 0.6 g/dL, p < 0.001; OR 0.38 (0.22-0.66), p = 0.001] and started haemodialysis with a central venous catheter more frequently [80.4% versus 66.2%, p = 0.050]. Multivariate analysis identified older age [aOR 1.07 (1.03-1.12), p = 0.002], lower serum creatinine [aOR 0.80 (0.64-0.99), p = 0.049] and lower serum albumin [aOR 0.41 (0.22-0.75), p = 0.004] as predictors of one-year mortality. Conclusion: In our cohort, older age, lower serum creatinine and lower serum albumin were independent risk factors for one-year mortality, highlighting the prognostic importance of malnutrition in patients starting chronic HD.MDPIRepositório da Universidade de LisboaCardoso, AnaBranco, CarolinaSant’Ana, MarianaCosta, CláudiaMarques Da Silva, BernardoAgapito Fonseca, JoséOuterelo, CristinaGameiro, Joana2023-10-16T14:07:47Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/59788engJ Clin Med. 2021 Sep 29;10(19):4518.10.3390/jcm101945182077-0383info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T15:02:00Zoai:repositorio.ulisboa.pt:10451/59788Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:32:02.307985Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Hypoalbuminaemia and one-year mortality in haemodialysis patients with heart failure: a cohort analysis
title Hypoalbuminaemia and one-year mortality in haemodialysis patients with heart failure: a cohort analysis
spellingShingle Hypoalbuminaemia and one-year mortality in haemodialysis patients with heart failure: a cohort analysis
Cardoso, Ana
Chronic haemodialysis
Heart failure
Hypoalbuminaemia
Malnutrition
Mortality
title_short Hypoalbuminaemia and one-year mortality in haemodialysis patients with heart failure: a cohort analysis
title_full Hypoalbuminaemia and one-year mortality in haemodialysis patients with heart failure: a cohort analysis
title_fullStr Hypoalbuminaemia and one-year mortality in haemodialysis patients with heart failure: a cohort analysis
title_full_unstemmed Hypoalbuminaemia and one-year mortality in haemodialysis patients with heart failure: a cohort analysis
title_sort Hypoalbuminaemia and one-year mortality in haemodialysis patients with heart failure: a cohort analysis
author Cardoso, Ana
author_facet Cardoso, Ana
Branco, Carolina
Sant’Ana, Mariana
Costa, Cláudia
Marques Da Silva, Bernardo
Agapito Fonseca, José
Outerelo, Cristina
Gameiro, Joana
author_role author
author2 Branco, Carolina
Sant’Ana, Mariana
Costa, Cláudia
Marques Da Silva, Bernardo
Agapito Fonseca, José
Outerelo, Cristina
Gameiro, Joana
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Cardoso, Ana
Branco, Carolina
Sant’Ana, Mariana
Costa, Cláudia
Marques Da Silva, Bernardo
Agapito Fonseca, José
Outerelo, Cristina
Gameiro, Joana
dc.subject.por.fl_str_mv Chronic haemodialysis
Heart failure
Hypoalbuminaemia
Malnutrition
Mortality
topic Chronic haemodialysis
Heart failure
Hypoalbuminaemia
Malnutrition
Mortality
description © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01T00:00:00Z
2023-10-16T14:07:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/59788
url http://hdl.handle.net/10451/59788
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Clin Med. 2021 Sep 29;10(19):4518.
10.3390/jcm10194518
2077-0383
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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