Direct application of the INNO-LiPA Rif.TB line-probe assay for rapid identification of Mycobacterium tuberculosis complex strains and detection of rifampin resistance in 360 Mycobacterium tuberculosis complex strains and detection of rifampin resistance in 360 smear-positive respiratory specimens from an area of high incidence of multidrug-resistant tuberculosis

• Main Author: Viveiros, M
• Publication Date: 2005
• Other Authors: Leandro, C, Rodrigues, L, Almeida, J, Bettencourt, R, Couto, I, Carrilho, L, Diogo, J, Fonseca, A, Lito, L, Lopes, J, Pacheco, T, Pessanha, M, Quirim, J, Sancho, L, Salfinger, M, Amaral, L
• Format: Article
• Language: eng
• Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
• Download full: http://hdl.handle.net/10400.10/416
• topic: Tuberculose; Tuberculose pulmonar; Portugal; Mycobacterium tuberculosis; Multidrug-resistant tuberculosis

The INNO-LiPA Rif.TB assay for the identification of Mycobacterium tuberculosis complex strains and the detection of rifampin (RIF) resistance has been evaluated with 360 smear-positive respiratory specimens from an area of high incidence of multidrug-resistant tuberculosis (MDR-TB). The sensitivity when compared to conventional identification/culture methods was 82.2%, and the specificity was 66.7%; the sensitivity and specificity were 100.0% and 96.9%, respectively, for the detection of RIF resistance. This assay has the potential to provide rapid information that is essential for the effective management of MDR-TB.