Diffusion of anti-VEGF injections in the Portuguese National Health System

Bibliographic Details
Main Author: Marques, Ana Patricia
Publication Date: 2015
Other Authors: Macedo, Antonio Filipe, Perelman, Julian, Aguiar, Pedro, Rocha-Sousa, Amandio, Santana, Rui
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/31590
Summary: PMID: 26597866 WOS:000368840100104
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spelling Diffusion of anti-VEGF injections in the Portuguese National Health SystemMACULAR DEGENERATIONVISUAL IMPAIRMENTOLDER-ADULTSRANIBIZUMABEYEBEVACIZUMABPOPULATIONBLINDNESSOUTCOMESHORIZONPMID: 26597866 WOS:000368840100104Objectives: To analyse the temporal and geographical diffusion of antivascular endothelial growth factor (anti-VEGF) interventions, and its determinants in a National Health System (NHS). Setting: NHS Portuguese hospitals. Participants: All inpatient and day cases related to eye diseases at all Portuguese public hospitals for the period 2002-2012 were selected on the basis of four International Classification of Diseases 9th revision, Clinical Modification (ICD-9-CM) codes for procedures: 1474, 1475, 1479 and 149. Primary and secondary outcome measures: We measured anti-VEGF treatment rates by year and county. The determinants of the geographical diffusion were investigated using generalised linear modelling. Results: We analysed all hospital discharges from all NHS hospitals in Portugal (98 408 hospital discharges corresponding to 57 984 patients). National rates of hospitals episodes for the codes for procedures used were low before anti-VEGF approval in 2007 (less than 12% of hospital discharges). Between 2007 and 2012, the rates of hospital episodes related to the introduction of anti-VEGF injections increased by 27% per year. Patients from areas without ophthalmology departments received fewer treatments than those from areas with ophthalmology departments. The availability of an ophthalmology department in the county increased the rates of hospital episodes by 243%, and a 100-persons greater density per km(2) raised the rates by 11%. Conclusions: Our study shows a large but unequal diffusion of anti-VEGF treatments despite the universal coverage and very low copayments. The technological innovation in ophthalmology may thus produce unexpected inequalities related to financial constraints unless the implementation of innovative techniques is planned and regulated.Escola Nacional de Saúde Pública (ENSP)RUNMarques, Ana PatriciaMacedo, Antonio FilipePerelman, JulianAguiar, PedroRocha-Sousa, AmandioSantana, Rui2018-03-02T23:05:07Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article7application/pdfhttp://hdl.handle.net/10362/31590eng2044-6055PURE: 1718142https://doi.org/10.1136/bmjopen-2015-009006info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:31:05Zoai:run.unl.pt:10362/31590Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:02:13.044639Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Diffusion of anti-VEGF injections in the Portuguese National Health System
title Diffusion of anti-VEGF injections in the Portuguese National Health System
spellingShingle Diffusion of anti-VEGF injections in the Portuguese National Health System
Marques, Ana Patricia
MACULAR DEGENERATION
VISUAL IMPAIRMENT
OLDER-ADULTS
RANIBIZUMAB
EYE
BEVACIZUMAB
POPULATION
BLINDNESS
OUTCOMES
HORIZON
title_short Diffusion of anti-VEGF injections in the Portuguese National Health System
title_full Diffusion of anti-VEGF injections in the Portuguese National Health System
title_fullStr Diffusion of anti-VEGF injections in the Portuguese National Health System
title_full_unstemmed Diffusion of anti-VEGF injections in the Portuguese National Health System
title_sort Diffusion of anti-VEGF injections in the Portuguese National Health System
author Marques, Ana Patricia
author_facet Marques, Ana Patricia
Macedo, Antonio Filipe
Perelman, Julian
Aguiar, Pedro
Rocha-Sousa, Amandio
Santana, Rui
author_role author
author2 Macedo, Antonio Filipe
Perelman, Julian
Aguiar, Pedro
Rocha-Sousa, Amandio
Santana, Rui
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Escola Nacional de Saúde Pública (ENSP)
RUN
dc.contributor.author.fl_str_mv Marques, Ana Patricia
Macedo, Antonio Filipe
Perelman, Julian
Aguiar, Pedro
Rocha-Sousa, Amandio
Santana, Rui
dc.subject.por.fl_str_mv MACULAR DEGENERATION
VISUAL IMPAIRMENT
OLDER-ADULTS
RANIBIZUMAB
EYE
BEVACIZUMAB
POPULATION
BLINDNESS
OUTCOMES
HORIZON
topic MACULAR DEGENERATION
VISUAL IMPAIRMENT
OLDER-ADULTS
RANIBIZUMAB
EYE
BEVACIZUMAB
POPULATION
BLINDNESS
OUTCOMES
HORIZON
description PMID: 26597866 WOS:000368840100104
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
2018-03-02T23:05:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/31590
url http://hdl.handle.net/10362/31590
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2044-6055
PURE: 1718142
https://doi.org/10.1136/bmjopen-2015-009006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 7
application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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