Combination of aloe vera improves the biological performance of chitosan membranes for skin tissue repair

Bibliographic Details
Main Author: Silva, Simone Santos
Publication Date: 2013
Other Authors: Popa, Elena Geta, Gomes, Manuela E., Cerqueira, M. T., Marques, A. P., Caridade, S. G., Mano, J. F., Reis, R. L.
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/1822/27101
Summary: Publicado em "Journal of Tissue Engineering and Regenerative Medicine", vol. 7, suppl. 1 (2013)
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spelling Combination of aloe vera improves the biological performance of chitosan membranes for skin tissue repairAloe veraChitosanMembranesPublicado em "Journal of Tissue Engineering and Regenerative Medicine", vol. 7, suppl. 1 (2013)In the last years, aloe vera (AV), a tropical plant belonging to theliliaceaefamily, has gained popularity for medical, cosmetic and nutritional purposes. Commercially, AV appears in food supplements, as additive to drinks, coating fruits, moisturizer, and healing agent in cosmetic products, among others uses. The interest in AV comes from its chemical diversity and biological properties, which includes analgesic, antiinflammatory, wound healing, antibacterial, immune modulation and anti-tumor activities. Therefore, the use of the therapeutic properties of AV gel could be very useful in the creation of materials for regenerative medicine. In the present work, the biomedical potential of systems composed by AV gel and chitosan (Cht), a natural polysaccharide, was assessed by processing them into membranes by solvent casting. Additionally, the blended system was crosslinked with genipin, a natural crosslinker agent. The crosslinking will bring the possibility to control the leaching out of AV gel portion from the blended membranes. The developed blended membranes were characterized by rough surfaces and controllable degradation behavior. Besides, the non- and crosslinked blended membranes have an increased stiffness and viscoelastic behavior as compared to chitosan membranes. Thus, these membranes will facilitate the penetration of the AV gel onto the skin, and the membrane may act at different stages of the healing process, while protecting the injury from infection. Additionally, chitosan will increase the stability of the polysaccharides and/or compounds present in the AV composition, which can in turn keep their natural biological activity. To examine cell behavior in the developed membranes, human dermalfibroblasts (hDfs) were seeded in the membranes. The results haven shown that the blended membranes were more favorable for hDfs adhesion and proliferation in comparison with chitosan membranes. Furthermore, the calcein-AM results are in agreement with the findings obtained from the alamar blue assay (cellular viability) and DNA quantification (cell proliferation), suggesting that they are viable independently of the cell number present on the membrane surface. All findings indicated that the produced blended membranes present adequate properties for skin applications, namely as wound dressing materials.John Wiley and SonsUniversidade do MinhoSilva, Simone SantosPopa, Elena GetaGomes, Manuela E.Cerqueira, M. T.Marques, A. P.Caridade, S. G.Mano, J. F.Reis, R. L.2013-092013-09-01T00:00:00Zconference objectinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/1822/27101enghttp://onlinelibrary.wiley.com/doi/10.1002/term.2013.7.issue-s1/issuetocinfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-11T04:16:39Zoai:repositorium.sdum.uminho.pt:1822/27101Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T14:44:19.295600Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Combination of aloe vera improves the biological performance of chitosan membranes for skin tissue repair
title Combination of aloe vera improves the biological performance of chitosan membranes for skin tissue repair
spellingShingle Combination of aloe vera improves the biological performance of chitosan membranes for skin tissue repair
Silva, Simone Santos
Aloe vera
Chitosan
Membranes
title_short Combination of aloe vera improves the biological performance of chitosan membranes for skin tissue repair
title_full Combination of aloe vera improves the biological performance of chitosan membranes for skin tissue repair
title_fullStr Combination of aloe vera improves the biological performance of chitosan membranes for skin tissue repair
title_full_unstemmed Combination of aloe vera improves the biological performance of chitosan membranes for skin tissue repair
title_sort Combination of aloe vera improves the biological performance of chitosan membranes for skin tissue repair
author Silva, Simone Santos
author_facet Silva, Simone Santos
Popa, Elena Geta
Gomes, Manuela E.
Cerqueira, M. T.
Marques, A. P.
Caridade, S. G.
Mano, J. F.
Reis, R. L.
author_role author
author2 Popa, Elena Geta
Gomes, Manuela E.
Cerqueira, M. T.
Marques, A. P.
Caridade, S. G.
Mano, J. F.
Reis, R. L.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Silva, Simone Santos
Popa, Elena Geta
Gomes, Manuela E.
Cerqueira, M. T.
Marques, A. P.
Caridade, S. G.
Mano, J. F.
Reis, R. L.
dc.subject.por.fl_str_mv Aloe vera
Chitosan
Membranes
topic Aloe vera
Chitosan
Membranes
description Publicado em "Journal of Tissue Engineering and Regenerative Medicine", vol. 7, suppl. 1 (2013)
publishDate 2013
dc.date.none.fl_str_mv 2013-09
2013-09-01T00:00:00Z
dc.type.driver.fl_str_mv conference object
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/27101
url http://hdl.handle.net/1822/27101
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://onlinelibrary.wiley.com/doi/10.1002/term.2013.7.issue-s1/issuetoc
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley and Sons
publisher.none.fl_str_mv John Wiley and Sons
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
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collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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