Etanercept-Induced Interstitial Lung Disease in a Patient with Plaque Psoriasis

Detalhes bibliográficos
Autor(a) principal: Lopes, Jorge
Data de Publicação: 2019
Outros Autores: Campainha, Sérgio, Sousa, Cristina, Teixeira, Diogo, Baptista, Armando, Moreira, Ana
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: https://doi.org/10.29021/spdv.77.3.1098
Resumo: Etanercept is one of the biologic drugs approved for the treatment of psoriasis. Despite its wide use and proven efficacy, few cases of pulmonary toxicity have been reported.We present a patient with psoriasis vulgaris medicated with etanercept. Seven months after its start, the patient developed productive cough, with no fever or constitutional symptoms. The thoracic computerized tomography revealed a pattern of bilateral dense micronodules, with predominance in the superior lobes. After suspension of etanercept, there was symptomatic and imaging resolution, without the need for additional pharmacological treatment. We switched the biologic agent for ustekinumab, with goodtolerance and high efficacy.
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spelling Etanercept-Induced Interstitial Lung Disease in a Patient with Plaque PsoriasisDoença Pulmonar Intersticial Induzida por Etanercept em Doente com Psoríase em PlacasEtanercept/adverse effectsLung DiseasesInterstitial/chemically inducedPsoriasis/drug therapyPsoríasereações adversas a fármacosdoença pulmonar intersticialetanerceptEtanercept is one of the biologic drugs approved for the treatment of psoriasis. Despite its wide use and proven efficacy, few cases of pulmonary toxicity have been reported.We present a patient with psoriasis vulgaris medicated with etanercept. Seven months after its start, the patient developed productive cough, with no fever or constitutional symptoms. The thoracic computerized tomography revealed a pattern of bilateral dense micronodules, with predominance in the superior lobes. After suspension of etanercept, there was symptomatic and imaging resolution, without the need for additional pharmacological treatment. We switched the biologic agent for ustekinumab, with goodtolerance and high efficacy.O etanercept é um dos fármacos biológicos aprovados para o tratamento da psoríase. Apesar da sua vasta utilização e comprovada eficácia, estão descritos raros casos de toxicidade pulmonar com a sua utilização.Apresentamos uma doente com psoríase vulgar medicada com etanercept. Sete meses após o início do fármaco, inicia um quadro de tosse produtiva, sem febre ou sintomas constitucionais. Na tomografia computorizada torácica, apresentava um padrão de micronódulos densos bilaterais, com predomínio nos lobos superiores. Após suspensão do agente verificou-se resolução sintomática e imagiológica, sem necessidade de tratamento farmacológico adicional. Optou-se pela troca de agente biológicopara ustecinumab, com boa tolerância e elevada eficácia.Sociedade Portuguesa de Dermatologia e Venereologia2019-10-11T00:00:00Zjournal articleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.29021/spdv.77.3.1098oai:ojs.revista.spdv.com.pt:article/1098Journal of the Portuguese Society of Dermatology and Venereology; Vol 77 No 3 (2019): July / September; 245-248Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 77 n. 3 (2019): Julho / Setembro; 245-2482182-24092182-2395reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAPporhttps://revista.spdv.com.pt/index.php/spdv/article/view/1098https://doi.org/10.29021/spdv.77.3.1098https://revista.spdv.com.pt/index.php/spdv/article/view/1098/792Lopes, JorgeCampainha, SérgioSousa, CristinaTeixeira, DiogoBaptista, ArmandoMoreira, Anainfo:eu-repo/semantics/openAccess2022-10-06T12:35:12Zoai:ojs.revista.spdv.com.pt:article/1098Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T10:31:24.841302Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Etanercept-Induced Interstitial Lung Disease in a Patient with Plaque Psoriasis
Doença Pulmonar Intersticial Induzida por Etanercept em Doente com Psoríase em Placas
title Etanercept-Induced Interstitial Lung Disease in a Patient with Plaque Psoriasis
spellingShingle Etanercept-Induced Interstitial Lung Disease in a Patient with Plaque Psoriasis
Lopes, Jorge
Etanercept/adverse effects
Lung Diseases
Interstitial/chemically induced
Psoriasis/drug therapy
Psoríase
reações adversas a fármacos
doença pulmonar intersticial
etanercept
title_short Etanercept-Induced Interstitial Lung Disease in a Patient with Plaque Psoriasis
title_full Etanercept-Induced Interstitial Lung Disease in a Patient with Plaque Psoriasis
title_fullStr Etanercept-Induced Interstitial Lung Disease in a Patient with Plaque Psoriasis
title_full_unstemmed Etanercept-Induced Interstitial Lung Disease in a Patient with Plaque Psoriasis
title_sort Etanercept-Induced Interstitial Lung Disease in a Patient with Plaque Psoriasis
author Lopes, Jorge
author_facet Lopes, Jorge
Campainha, Sérgio
Sousa, Cristina
Teixeira, Diogo
Baptista, Armando
Moreira, Ana
author_role author
author2 Campainha, Sérgio
Sousa, Cristina
Teixeira, Diogo
Baptista, Armando
Moreira, Ana
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Lopes, Jorge
Campainha, Sérgio
Sousa, Cristina
Teixeira, Diogo
Baptista, Armando
Moreira, Ana
dc.subject.por.fl_str_mv Etanercept/adverse effects
Lung Diseases
Interstitial/chemically induced
Psoriasis/drug therapy
Psoríase
reações adversas a fármacos
doença pulmonar intersticial
etanercept
topic Etanercept/adverse effects
Lung Diseases
Interstitial/chemically induced
Psoriasis/drug therapy
Psoríase
reações adversas a fármacos
doença pulmonar intersticial
etanercept
description Etanercept is one of the biologic drugs approved for the treatment of psoriasis. Despite its wide use and proven efficacy, few cases of pulmonary toxicity have been reported.We present a patient with psoriasis vulgaris medicated with etanercept. Seven months after its start, the patient developed productive cough, with no fever or constitutional symptoms. The thoracic computerized tomography revealed a pattern of bilateral dense micronodules, with predominance in the superior lobes. After suspension of etanercept, there was symptomatic and imaging resolution, without the need for additional pharmacological treatment. We switched the biologic agent for ustekinumab, with goodtolerance and high efficacy.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-11T00:00:00Z
dc.type.driver.fl_str_mv journal article
info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.29021/spdv.77.3.1098
oai:ojs.revista.spdv.com.pt:article/1098
url https://doi.org/10.29021/spdv.77.3.1098
identifier_str_mv oai:ojs.revista.spdv.com.pt:article/1098
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revista.spdv.com.pt/index.php/spdv/article/view/1098
https://doi.org/10.29021/spdv.77.3.1098
https://revista.spdv.com.pt/index.php/spdv/article/view/1098/792
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Dermatologia e Venereologia
publisher.none.fl_str_mv Sociedade Portuguesa de Dermatologia e Venereologia
dc.source.none.fl_str_mv Journal of the Portuguese Society of Dermatology and Venereology; Vol 77 No 3 (2019): July / September; 245-248
Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 77 n. 3 (2019): Julho / Setembro; 245-248
2182-2409
2182-2395
reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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