Tissue oxygen demand in regulation of the behavior of the cells in the vasculature
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Texto Completo: | http://hdl.handle.net/10451/10674 |
Resumo: | © 2013 John Wiley & Sons Ltd |
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Tissue oxygen demand in regulation of the behavior of the cells in the vasculatureMicrovascular blood flowTissue oxygen demandRed blood cellEndothelial cellVascular smooth muscle cellRegulation© 2013 John Wiley & Sons LtdThe control of arteriolar diameters in microvasculature has been in the focus of studies on mechanisms matching oxygen demand and supply at the tissue level. Functionally, important vascular elements include EC, VSMC, and RBC. Integration of these different cell types into functional units aimed at matching tissue oxygen supply with tissue oxygen demand is only achieved when all these cells can respond to the signals of tissue oxygen demand. Many vasoactive agents that serve as signals of tissue oxygen demand have their receptors on all these types of cells (VSMC, EC, and RBC) implying that there can be a coordinated regulation of their behavior by the tissue oxygen demand. Such functions of RBC as oxygen carrying by Hb, rheology, and release of vasoactive agents are considered. Several common extra- and intracellular signaling pathways that link tissue oxygen demand with control of VSMC contractility, EC permeability, and RBC functioning are discussed.John Wiley & SonsRepositório da Universidade de LisboaBarvitenko, Nadezhda N.Aslam, MuhammadFilosa, JessicaMatteucci, ElenaNikinmaa, MikkoPantaleo, AntonellaSaldanha, CarlotaBaskurt, Oguz K.2014-03-04T16:54:34Z20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/10674engMicrocirculation 20: 484–501, 20131073-9688http://dx.doi.org/10.1111/micc.12052metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T13:06:35Zoai:repositorio.ulisboa.pt:10451/10674Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T02:35:07.293227Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
Tissue oxygen demand in regulation of the behavior of the cells in the vasculature |
| title |
Tissue oxygen demand in regulation of the behavior of the cells in the vasculature |
| spellingShingle |
Tissue oxygen demand in regulation of the behavior of the cells in the vasculature Barvitenko, Nadezhda N. Microvascular blood flow Tissue oxygen demand Red blood cell Endothelial cell Vascular smooth muscle cell Regulation |
| title_short |
Tissue oxygen demand in regulation of the behavior of the cells in the vasculature |
| title_full |
Tissue oxygen demand in regulation of the behavior of the cells in the vasculature |
| title_fullStr |
Tissue oxygen demand in regulation of the behavior of the cells in the vasculature |
| title_full_unstemmed |
Tissue oxygen demand in regulation of the behavior of the cells in the vasculature |
| title_sort |
Tissue oxygen demand in regulation of the behavior of the cells in the vasculature |
| author |
Barvitenko, Nadezhda N. |
| author_facet |
Barvitenko, Nadezhda N. Aslam, Muhammad Filosa, Jessica Matteucci, Elena Nikinmaa, Mikko Pantaleo, Antonella Saldanha, Carlota Baskurt, Oguz K. |
| author_role |
author |
| author2 |
Aslam, Muhammad Filosa, Jessica Matteucci, Elena Nikinmaa, Mikko Pantaleo, Antonella Saldanha, Carlota Baskurt, Oguz K. |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Barvitenko, Nadezhda N. Aslam, Muhammad Filosa, Jessica Matteucci, Elena Nikinmaa, Mikko Pantaleo, Antonella Saldanha, Carlota Baskurt, Oguz K. |
| dc.subject.por.fl_str_mv |
Microvascular blood flow Tissue oxygen demand Red blood cell Endothelial cell Vascular smooth muscle cell Regulation |
| topic |
Microvascular blood flow Tissue oxygen demand Red blood cell Endothelial cell Vascular smooth muscle cell Regulation |
| description |
© 2013 John Wiley & Sons Ltd |
| publishDate |
2013 |
| dc.date.none.fl_str_mv |
2013 2013-01-01T00:00:00Z 2014-03-04T16:54:34Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10451/10674 |
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http://hdl.handle.net/10451/10674 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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Microcirculation 20: 484–501, 2013 1073-9688 http://dx.doi.org/10.1111/micc.12052 |
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metadata only access info:eu-repo/semantics/openAccess |
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metadata only access |
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openAccess |
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application/pdf |
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John Wiley & Sons |
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John Wiley & Sons |
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reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia instacron:RCAAP |
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RCAAP |
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Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
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Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia |
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info@rcaap.pt |
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