Combining experiments and in silico modeling to infer the role of adhesion and proliferation on the collective dynamics of cells

Bibliographic Details
Main Author: Melo, H. P. M.
Publication Date: 2021
Other Authors: Maia, F. Raquel, Nunes, A. S., Reis, R. L., Oliveira, J. M., Araújo, N. A. M.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://hdl.handle.net/1822/74291
Summary: Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1038/s41598-021-99390-x.
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spelling Combining experiments and in silico modeling to infer the role of adhesion and proliferation on the collective dynamics of cellsCell adhesionCell collective dynamicsCell proliferationIn silico modelingEngenharia e Tecnologia::Biotecnologia IndustrialScience & TechnologySupplementary Information: The online version contains supplementary material available at https://doi.org/10.1038/s41598-021-99390-x.The collective dynamics of cells on surfaces and interfaces poses technological and theoretical challenges in the study of morphogenesis, tissue engineering, and cancer. Different mechanisms are at play, including, cellâ cell adhesion, cell motility, and proliferation. However, the relative importance of each one is elusive. Here, experiments with a culture of glioblastoma multiforme cells on a substrate are combined with in silico modeling to infer the rate of each mechanism. By parametrizing these rates, the time-dependence of the spatial correlation observed experimentally is reproduced. The obtained results suggest a reduction in cellâ cell adhesion with the density of cells. The reason for such reduction and possible implications for the collective dynamics of cancer cells are discussed.The authors acknowledge fnancial support from the Portuguese Foundation for Science and Technology (FCT) under Contracts no. PTDC/FIS-MAC/28146/2017 (LISBOA-01-0145-FEDER-028146), UIDB/00618/2020, and UIDP/00618/2020. F.R.M. also acknowledges FCT for her contract under the Transitional Rule DL 57/2016 (CTTI-57/18-I3BS(5)).Nature ResearchUniversidade do MinhoMelo, H. P. M.Maia, F. RaquelNunes, A. S.Reis, R. L.Oliveira, J. M.Araújo, N. A. M.2021-102021-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/74291engMelo H. P. M., Maia F. R., Nunes A. S., Reis R. L., Oliveira J. M., Araújo N. A. M. Combining experiments and in silico modeling to infer the role of adhesion and proliferation on the collective dynamics of cells, Scientific Reports, Vol. 11, pp. 19894, doi:10.1038/s41598-021-99390-x, 20212045-23222045-232210.1038/s41598-021-99390-x34615941https://www.nature.com/articles/s41598-021-99390-xinfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-11T04:36:37Zoai:repositorium.sdum.uminho.pt:1822/74291Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T14:53:20.024227Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Combining experiments and in silico modeling to infer the role of adhesion and proliferation on the collective dynamics of cells
title Combining experiments and in silico modeling to infer the role of adhesion and proliferation on the collective dynamics of cells
spellingShingle Combining experiments and in silico modeling to infer the role of adhesion and proliferation on the collective dynamics of cells
Melo, H. P. M.
Cell adhesion
Cell collective dynamics
Cell proliferation
In silico modeling
Engenharia e Tecnologia::Biotecnologia Industrial
Science & Technology
title_short Combining experiments and in silico modeling to infer the role of adhesion and proliferation on the collective dynamics of cells
title_full Combining experiments and in silico modeling to infer the role of adhesion and proliferation on the collective dynamics of cells
title_fullStr Combining experiments and in silico modeling to infer the role of adhesion and proliferation on the collective dynamics of cells
title_full_unstemmed Combining experiments and in silico modeling to infer the role of adhesion and proliferation on the collective dynamics of cells
title_sort Combining experiments and in silico modeling to infer the role of adhesion and proliferation on the collective dynamics of cells
author Melo, H. P. M.
author_facet Melo, H. P. M.
Maia, F. Raquel
Nunes, A. S.
Reis, R. L.
Oliveira, J. M.
Araújo, N. A. M.
author_role author
author2 Maia, F. Raquel
Nunes, A. S.
Reis, R. L.
Oliveira, J. M.
Araújo, N. A. M.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Melo, H. P. M.
Maia, F. Raquel
Nunes, A. S.
Reis, R. L.
Oliveira, J. M.
Araújo, N. A. M.
dc.subject.por.fl_str_mv Cell adhesion
Cell collective dynamics
Cell proliferation
In silico modeling
Engenharia e Tecnologia::Biotecnologia Industrial
Science & Technology
topic Cell adhesion
Cell collective dynamics
Cell proliferation
In silico modeling
Engenharia e Tecnologia::Biotecnologia Industrial
Science & Technology
description Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1038/s41598-021-99390-x.
publishDate 2021
dc.date.none.fl_str_mv 2021-10
2021-10-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/74291
url https://hdl.handle.net/1822/74291
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Melo H. P. M., Maia F. R., Nunes A. S., Reis R. L., Oliveira J. M., Araújo N. A. M. Combining experiments and in silico modeling to infer the role of adhesion and proliferation on the collective dynamics of cells, Scientific Reports, Vol. 11, pp. 19894, doi:10.1038/s41598-021-99390-x, 2021
2045-2322
2045-2322
10.1038/s41598-021-99390-x
34615941
https://www.nature.com/articles/s41598-021-99390-x
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833594954461478912

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