Subsyndromal delirium in critically ill patients: cognitive and functional long-term outcomes

Bibliographic Details
Main Author: Paulino, Maria Carolina
Publication Date: 2023
Other Authors: Conceição, Catarina, Silvestre, Joana, Lopes, Maria Inês, Gonçalves, Hernâni, Dias, Cláudia Camila, Serafim, Rodrigo, Salluh, Jorge I. F., Póvoa, Pedro
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/60253
Summary: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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spelling Subsyndromal delirium in critically ill patients: cognitive and functional long-term outcomesICUCognitive dysfunctionDeliriumLong-term outcomeSubsyndromal delirium© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Subsyndromal delirium (SSD) in the Intensive Care Unit (ICU) is associated with an increased morbidity with unknown post-discharge functional and cognitive outcomes. We performed a prospective multicenter study to analyze the mental status of patients during their first 72 h after ICU admission and its trajectory, with follow-ups at 3 and 6 months after hospital discharge. Amongst the 106 included patients, SSD occurred in 24.5% (n = 26) and was associated with the duration of mechanical ventilation (p = 0.003) and the length of the ICU stay (p = 0.002). After the initial 72 h, most of the SSD patients (30.8%) improved and no longer had SSD; 19.2% continued to experience SSD and one patient (3.8%) progressed to delirium. The post-hospital discharge survival rate for the SSD patients was 100% at 3 months and 87.5% at 6 months. At admission, 96.2% of the SSD patients were fully independent in daily living activities, 66.7% at 3-month follow-up, and 100% at 6-month follow-up. Most SSD patients demonstrated a cognitive decline from admission to 3-month follow-up and improved at 6 months (IQCODE-SF: admission 3.13, p < 0.001; 3 months 3.41, p = 0.019; 6 months 3.19, p = 0.194). We concluded that early SSD is associated with worse outcomes, mainly a transitory cognitive decline after hospital discharge at 3 months, with an improvement at 6 months. This highlights the need to prevent and identify this condition during ICU stays.MDPIRepositório da Universidade de LisboaPaulino, Maria CarolinaConceição, CatarinaSilvestre, JoanaLopes, Maria InêsGonçalves, HernâniDias, Cláudia CamilaSerafim, RodrigoSalluh, Jorge I. F.Póvoa, Pedro2023-11-09T14:38:43Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/60253engJ Clin Med. 2023 Oct 4;12(19):636310.3390/jcm121963632077-0383info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T15:04:25Zoai:repositorio.ulisboa.pt:10451/60253Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:32:59.920042Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Subsyndromal delirium in critically ill patients: cognitive and functional long-term outcomes
title Subsyndromal delirium in critically ill patients: cognitive and functional long-term outcomes
spellingShingle Subsyndromal delirium in critically ill patients: cognitive and functional long-term outcomes
Paulino, Maria Carolina
ICU
Cognitive dysfunction
Delirium
Long-term outcome
Subsyndromal delirium
title_short Subsyndromal delirium in critically ill patients: cognitive and functional long-term outcomes
title_full Subsyndromal delirium in critically ill patients: cognitive and functional long-term outcomes
title_fullStr Subsyndromal delirium in critically ill patients: cognitive and functional long-term outcomes
title_full_unstemmed Subsyndromal delirium in critically ill patients: cognitive and functional long-term outcomes
title_sort Subsyndromal delirium in critically ill patients: cognitive and functional long-term outcomes
author Paulino, Maria Carolina
author_facet Paulino, Maria Carolina
Conceição, Catarina
Silvestre, Joana
Lopes, Maria Inês
Gonçalves, Hernâni
Dias, Cláudia Camila
Serafim, Rodrigo
Salluh, Jorge I. F.
Póvoa, Pedro
author_role author
author2 Conceição, Catarina
Silvestre, Joana
Lopes, Maria Inês
Gonçalves, Hernâni
Dias, Cláudia Camila
Serafim, Rodrigo
Salluh, Jorge I. F.
Póvoa, Pedro
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Paulino, Maria Carolina
Conceição, Catarina
Silvestre, Joana
Lopes, Maria Inês
Gonçalves, Hernâni
Dias, Cláudia Camila
Serafim, Rodrigo
Salluh, Jorge I. F.
Póvoa, Pedro
dc.subject.por.fl_str_mv ICU
Cognitive dysfunction
Delirium
Long-term outcome
Subsyndromal delirium
topic ICU
Cognitive dysfunction
Delirium
Long-term outcome
Subsyndromal delirium
description © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
publishDate 2023
dc.date.none.fl_str_mv 2023-11-09T14:38:43Z
2023
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/60253
url http://hdl.handle.net/10451/60253
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Clin Med. 2023 Oct 4;12(19):6363
10.3390/jcm12196363
2077-0383
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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