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Sirtuins and SIRT6 in carcinogenesis and in diet

Bibliographic Details
Main Author: de Céu Teixeira, Maria
Publication Date: 2019
Other Authors: Sanchez-Lopez, Elena, Espina, Marta, Garcia, Maria Luisa, Durazzo, Alessandra, Lucarini, Massimo, Novellino, Ettore, Souto, Selma B., Santini, Antonello, Souto, Eliana B.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/1822/61785
Summary: Sirtuins are a highly conserved family of nicotinamide adenine dinucleotide (NAD)-dependent protein lysine modifying enzymes. They are key regulators for a wide variety of cellular and physiological processes such as cell proliferation, differentiation, DNA damage and stress response, genome stability, cell survival, metabolism, energy homeostasis, organ development and aging. Aging is one of the major risk factors of cancer, as many of the physiological mechanisms and pathologies associated with the aging process also contribute to tumor initiation, growth and/or metastasis. This review focuses on one the mammalian sirtuins, SIRT6, which has emerged as an important regulator of longevity and appears to have multiple biochemical functions that interfere with tumor development and may be useful in cancer prevention and for site-specific treatment. The recent evidence of the role of SIRT6 in carcinogenesis is also discussed, focusing on the potential use of SIRT6 modulators in cancer nanomedicine.
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spelling Sirtuins and SIRT6 in carcinogenesis and in dietsirtuinsSIRT6cancermodulatorchemotherapydietScience & TechnologySirtuins are a highly conserved family of nicotinamide adenine dinucleotide (NAD)-dependent protein lysine modifying enzymes. They are key regulators for a wide variety of cellular and physiological processes such as cell proliferation, differentiation, DNA damage and stress response, genome stability, cell survival, metabolism, energy homeostasis, organ development and aging. Aging is one of the major risk factors of cancer, as many of the physiological mechanisms and pathologies associated with the aging process also contribute to tumor initiation, growth and/or metastasis. This review focuses on one the mammalian sirtuins, SIRT6, which has emerged as an important regulator of longevity and appears to have multiple biochemical functions that interfere with tumor development and may be useful in cancer prevention and for site-specific treatment. The recent evidence of the role of SIRT6 in carcinogenesis is also discussed, focusing on the potential use of SIRT6 modulators in cancer nanomedicine.The authors would like to thank the financial support received from the Portuguese Science and Technology Foundation (FCT/MCT) and from European Funds (PRODER/COMPETE) under the project reference M-ERA-NET/0004/2015-PAIRED, co-financed by FEDER, under the Partnership Agreement PT2020. MCT wishes to acknowledge FCT and Dendropharma - Investigação E Serviços De Intervenção Farmacêutica, Sociedade Unipessoal Lda, for the individual fellowship (PDE/00017/2013). The Institute of Nanoscience and Nanotechnology is also acknowledged (project ART2018).Multidisciplinary Digital Publishing InstituteUniversidade do Minhode Céu Teixeira, MariaSanchez-Lopez, ElenaEspina, MartaGarcia, Maria LuisaDurazzo, AlessandraLucarini, MassimoNovellino, EttoreSouto, Selma B.Santini, AntonelloSouto, Eliana B.2019-10-072019-10-07T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/61785eng1661-659610.3390/ijms2019494531591350https://www.mdpi.com/1422-0067/20/19/4945info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-11T06:21:40Zoai:repositorium.sdum.uminho.pt:1822/61785Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T15:50:31.180986Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Sirtuins and SIRT6 in carcinogenesis and in diet
title Sirtuins and SIRT6 in carcinogenesis and in diet
spellingShingle Sirtuins and SIRT6 in carcinogenesis and in diet
de Céu Teixeira, Maria
sirtuins
SIRT6
cancer
modulator
chemotherapy
diet
Science & Technology
title_short Sirtuins and SIRT6 in carcinogenesis and in diet
title_full Sirtuins and SIRT6 in carcinogenesis and in diet
title_fullStr Sirtuins and SIRT6 in carcinogenesis and in diet
title_full_unstemmed Sirtuins and SIRT6 in carcinogenesis and in diet
title_sort Sirtuins and SIRT6 in carcinogenesis and in diet
author de Céu Teixeira, Maria
author_facet de Céu Teixeira, Maria
Sanchez-Lopez, Elena
Espina, Marta
Garcia, Maria Luisa
Durazzo, Alessandra
Lucarini, Massimo
Novellino, Ettore
Souto, Selma B.
Santini, Antonello
Souto, Eliana B.
author_role author
author2 Sanchez-Lopez, Elena
Espina, Marta
Garcia, Maria Luisa
Durazzo, Alessandra
Lucarini, Massimo
Novellino, Ettore
Souto, Selma B.
Santini, Antonello
Souto, Eliana B.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv de Céu Teixeira, Maria
Sanchez-Lopez, Elena
Espina, Marta
Garcia, Maria Luisa
Durazzo, Alessandra
Lucarini, Massimo
Novellino, Ettore
Souto, Selma B.
Santini, Antonello
Souto, Eliana B.
dc.subject.por.fl_str_mv sirtuins
SIRT6
cancer
modulator
chemotherapy
diet
Science & Technology
topic sirtuins
SIRT6
cancer
modulator
chemotherapy
diet
Science & Technology
description Sirtuins are a highly conserved family of nicotinamide adenine dinucleotide (NAD)-dependent protein lysine modifying enzymes. They are key regulators for a wide variety of cellular and physiological processes such as cell proliferation, differentiation, DNA damage and stress response, genome stability, cell survival, metabolism, energy homeostasis, organ development and aging. Aging is one of the major risk factors of cancer, as many of the physiological mechanisms and pathologies associated with the aging process also contribute to tumor initiation, growth and/or metastasis. This review focuses on one the mammalian sirtuins, SIRT6, which has emerged as an important regulator of longevity and appears to have multiple biochemical functions that interfere with tumor development and may be useful in cancer prevention and for site-specific treatment. The recent evidence of the role of SIRT6 in carcinogenesis is also discussed, focusing on the potential use of SIRT6 modulators in cancer nanomedicine.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-07
2019-10-07T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/61785
url http://hdl.handle.net/1822/61785
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1661-6596
10.3390/ijms20194945
31591350
https://www.mdpi.com/1422-0067/20/19/4945
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833595575013998592

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