Sustained drug released from contact lens

Bibliographic Details
Main Author: Ferreira, J. A.
Publication Date: 2009
Other Authors: Oliveira, P. de, Silva, P. M. da, Carreira, A., Gil, H., Murta, J. N.
Format: Other
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://hdl.handle.net/10316/11167
Summary: This paper focuses on ophthalmic drug release from a loaded copolymer: the drug is dispersed in the polymeric matrix and entrapped in particles. The copolymer is based in 2-hydroxyethyl methacrylate co-methacrylic acid and silicone is used to prepare the loaded particles. A mathematical model to simulate the drug release is proposed and a qualitative analysis is performed. Experimental results are compared with simulation results. Contact lens made from the presented copolymer are expected to deliver drug at therapeutical levels for a few days.
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spelling Sustained drug released from contact lensOphthalmic drug deliveryContact lensesp-(HEMA/MAA)Reaction-diffusion equationQualitative behaviourNumerical simulationExperimental resultsThis paper focuses on ophthalmic drug release from a loaded copolymer: the drug is dispersed in the polymeric matrix and entrapped in particles. The copolymer is based in 2-hydroxyethyl methacrylate co-methacrylic acid and silicone is used to prepare the loaded particles. A mathematical model to simulate the drug release is proposed and a qualitative analysis is performed. Experimental results are compared with simulation results. Contact lens made from the presented copolymer are expected to deliver drug at therapeutical levels for a few days.Project PTDC/MAT/74548/2006Centro de Matemática da Universidade de Coimbra2009info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherhttps://hdl.handle.net/10316/11167https://hdl.handle.net/10316/11167engPré-Publicações DMUC. 09-20 (2009)Ferreira, J. A.Oliveira, P. deSilva, P. M. daCarreira, A.Gil, H.Murta, J. N.info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2020-05-25T13:11:10Zoai:estudogeral.uc.pt:10316/11167Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T05:23:16.239180Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Sustained drug released from contact lens
title Sustained drug released from contact lens
spellingShingle Sustained drug released from contact lens
Ferreira, J. A.
Ophthalmic drug delivery
Contact lenses
p-(HEMA/MAA)
Reaction-diffusion equation
Qualitative behaviour
Numerical simulation
Experimental results
title_short Sustained drug released from contact lens
title_full Sustained drug released from contact lens
title_fullStr Sustained drug released from contact lens
title_full_unstemmed Sustained drug released from contact lens
title_sort Sustained drug released from contact lens
author Ferreira, J. A.
author_facet Ferreira, J. A.
Oliveira, P. de
Silva, P. M. da
Carreira, A.
Gil, H.
Murta, J. N.
author_role author
author2 Oliveira, P. de
Silva, P. M. da
Carreira, A.
Gil, H.
Murta, J. N.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Ferreira, J. A.
Oliveira, P. de
Silva, P. M. da
Carreira, A.
Gil, H.
Murta, J. N.
dc.subject.por.fl_str_mv Ophthalmic drug delivery
Contact lenses
p-(HEMA/MAA)
Reaction-diffusion equation
Qualitative behaviour
Numerical simulation
Experimental results
topic Ophthalmic drug delivery
Contact lenses
p-(HEMA/MAA)
Reaction-diffusion equation
Qualitative behaviour
Numerical simulation
Experimental results
description This paper focuses on ophthalmic drug release from a loaded copolymer: the drug is dispersed in the polymeric matrix and entrapped in particles. The copolymer is based in 2-hydroxyethyl methacrylate co-methacrylic acid and silicone is used to prepare the loaded particles. A mathematical model to simulate the drug release is proposed and a qualitative analysis is performed. Experimental results are compared with simulation results. Contact lens made from the presented copolymer are expected to deliver drug at therapeutical levels for a few days.
publishDate 2009
dc.date.none.fl_str_mv 2009
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10316/11167
https://hdl.handle.net/10316/11167
url https://hdl.handle.net/10316/11167
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pré-Publicações DMUC. 09-20 (2009)
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Centro de Matemática da Universidade de Coimbra
publisher.none.fl_str_mv Centro de Matemática da Universidade de Coimbra
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833602338310324224

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