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Exosomes and brain metastases: a review on their role and potential applications

Bibliographic Details
Main Author: Oliveira, Filipa
Publication Date: 2021
Other Authors: Castanho, Miguel A. R. B., Neves, Vera
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/57425
Summary: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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spelling Exosomes and brain metastases: a review on their role and potential applicationsExosomesTumor microenvironmentPre-metastatic nicheDrug delivery systemMetastatic cancerBrain metastasesBlood–brain barrier© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Brain metastases (BM) are a frequent complication in patients with advanced stages of cancer, associated with impairment of the neurological function, quality of life, prognosis, and survival. BM treatment consists of a combination of the available cancer therapies, such as surgery, radiotherapy, chemotherapy, immunotherapy and targeted therapies. Even so, cancer patients with BM are still linked to poor prognosis, with overall survival being reported as 12 months or less. Intercellular communication has a pivotal role in the development of metastases, therefore, it has been extensively studied not only to better understand the metastization process, but also to further develop new therapeutic strategies. Exosomes have emerged as key players in intercellular communication being potential therapeutic targets, drug delivery systems (DDS) or biomarkers. In this Review, we focus on the role of these extracellular vesicles (EVs) in BM formation and their promising application in the development of new BM therapeutic strategies.This research was funded by the Portuguese Funding Agency, Fundação para a Ciência e a Tecnologia, FCT IP, grants PD/BD/135046/2017, PTDC/BIA-BQM/5027/2020, DL 57/2016/CP1451/CT0023.MDPIRepositório da Universidade de LisboaOliveira, FilipaCastanho, Miguel A. R. B.Neves, Vera2023-05-15T13:38:17Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/57425engInt. J. Mol. Sci. 2021, 22(19), 108991661-659610.3390/ijms2219108991422-0067info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:56:52Zoai:repositorio.ulisboa.pt:10451/57425Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:29:36.323933Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Exosomes and brain metastases: a review on their role and potential applications
title Exosomes and brain metastases: a review on their role and potential applications
spellingShingle Exosomes and brain metastases: a review on their role and potential applications
Oliveira, Filipa
Exosomes
Tumor microenvironment
Pre-metastatic niche
Drug delivery system
Metastatic cancer
Brain metastases
Blood–brain barrier
title_short Exosomes and brain metastases: a review on their role and potential applications
title_full Exosomes and brain metastases: a review on their role and potential applications
title_fullStr Exosomes and brain metastases: a review on their role and potential applications
title_full_unstemmed Exosomes and brain metastases: a review on their role and potential applications
title_sort Exosomes and brain metastases: a review on their role and potential applications
author Oliveira, Filipa
author_facet Oliveira, Filipa
Castanho, Miguel A. R. B.
Neves, Vera
author_role author
author2 Castanho, Miguel A. R. B.
Neves, Vera
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Oliveira, Filipa
Castanho, Miguel A. R. B.
Neves, Vera
dc.subject.por.fl_str_mv Exosomes
Tumor microenvironment
Pre-metastatic niche
Drug delivery system
Metastatic cancer
Brain metastases
Blood–brain barrier
topic Exosomes
Tumor microenvironment
Pre-metastatic niche
Drug delivery system
Metastatic cancer
Brain metastases
Blood–brain barrier
description © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01T00:00:00Z
2023-05-15T13:38:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/57425
url http://hdl.handle.net/10451/57425
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Int. J. Mol. Sci. 2021, 22(19), 10899
1661-6596
10.3390/ijms221910899
1422-0067
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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