The effects of casein glycomacropeptide on general health status in children with PKU
| Main Author: | |
|---|---|
| Publication Date: | 2024 |
| Other Authors: | , , , , , , , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Download full: | http://hdl.handle.net/10362/176461 |
Summary: | Funding Information: This study was sponsored by Vitaflo International Ltd.\u00AE, UK and Arla Foods Ingredients Group P/S. Publisher Copyright: © 2024 |
| id |
RCAP_8574817bb5f1dab5d315874b152b0f9c |
|---|---|
| oai_identifier_str |
oai:run.unl.pt:10362/176461 |
| network_acronym_str |
RCAP |
| network_name_str |
Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| repository_id_str |
https://opendoar.ac.uk/repository/7160 |
| spelling |
The effects of casein glycomacropeptide on general health status in children with PKUA randomized crossover trialAmino acidsGastrointestinal symptomsGlycomacropeptideGut healthInflammationOxidative stressPhenylketonuriaRenal functionSatietyEndocrinology, Diabetes and MetabolismBiochemistryMolecular BiologyGeneticsEndocrinologySDG 3 - Good Health and Well-beingFunding Information: This study was sponsored by Vitaflo International Ltd.\u00AE, UK and Arla Foods Ingredients Group P/S. Publisher Copyright: © 2024In PKU, it is suggested that casein glycomacropeptide based protein substitute (GMP) may have physiological advantage when satiety, oxidative stress, renal function and inflammation are considered. Its prebiotic properties may also help gastrointestinal (GI) tolerance. In children with PKU, a randomized/crossover trial comparing phenylalanine-free amino acids (AA) vs GMP as the single source of protein substitute for 12-weeks in each arm was conducted. There was a 4-week wash out period with AA in-between. At baseline and end of each intervention, blood and fecal samples were taken to monitor gut health, oxidative stress, renal function, inflammatory markers and plasma amino acids. Satiety and Pediatric Quality of Life (PedsQL) GI symptoms questionnaires were completed. Usual weekly blood spots for phenylalanine and tyrosine were done. Twelve patients (8 males; aged 4-9y) with PKU participated. GMP improved the following GI symptoms: stomach pain (p = 0.003), heartburn and reflux (p = 0.041) wind and bloating (p = 0.018). With GMP, there was also a trend for less constipation (p = 0.068), discomfort with eating (p = 0.065) and nausea and vomiting (p = 0.087). There were no changes on stool gut health markers (IgA, short chain fatty acids and fecal calprotectin). There were no statistically significant differences for renal, oxidative stress, inflammatory and gut health markers or measures of satiety except for adiponectin (p = 0.028) and total antioxidant capacity (p = 0.049), although the latter was possibly without clinical significance. Mean dried blood spot phenylalanine (Phe) was 114 μmol/L higher with GMP vs AA (p < 0.001). There was no difference in tyrosine levels. In conclusion, GI symptoms statistically significantly improved with GMP versus AA. The Phe content of GMP may present challenges when it is used as the only protein substitute in children with classical PKU with low Phe tolerance.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS)Comprehensive Health Research Centre (CHRC) - pólo NMSRUNPinto, AlexDaly, AnneNewby, CamilleRobotham, AbigailHeales, SimonEaton, SimonAitkenhead, HelenGilmour, KimberlyJackson, RichardAshmore, CatherineEvans, SharonRocha, Júlio CesarIlgaz, FatmaHickson, MaryMacDonald, Anita2024-12-18T17:24:44Z2024-122024-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/176461eng1096-7192PURE: 103804415https://doi.org/10.1016/j.ymgme.2024.108607info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-04-14T01:38:00Zoai:run.unl.pt:10362/176461Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T19:19:46.918612Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
The effects of casein glycomacropeptide on general health status in children with PKU A randomized crossover trial |
| title |
The effects of casein glycomacropeptide on general health status in children with PKU |
| spellingShingle |
The effects of casein glycomacropeptide on general health status in children with PKU Pinto, Alex Amino acids Gastrointestinal symptoms Glycomacropeptide Gut health Inflammation Oxidative stress Phenylketonuria Renal function Satiety Endocrinology, Diabetes and Metabolism Biochemistry Molecular Biology Genetics Endocrinology SDG 3 - Good Health and Well-being |
| title_short |
The effects of casein glycomacropeptide on general health status in children with PKU |
| title_full |
The effects of casein glycomacropeptide on general health status in children with PKU |
| title_fullStr |
The effects of casein glycomacropeptide on general health status in children with PKU |
| title_full_unstemmed |
The effects of casein glycomacropeptide on general health status in children with PKU |
| title_sort |
The effects of casein glycomacropeptide on general health status in children with PKU |
| author |
Pinto, Alex |
| author_facet |
Pinto, Alex Daly, Anne Newby, Camille Robotham, Abigail Heales, Simon Eaton, Simon Aitkenhead, Helen Gilmour, Kimberly Jackson, Richard Ashmore, Catherine Evans, Sharon Rocha, Júlio Cesar Ilgaz, Fatma Hickson, Mary MacDonald, Anita |
| author_role |
author |
| author2 |
Daly, Anne Newby, Camille Robotham, Abigail Heales, Simon Eaton, Simon Aitkenhead, Helen Gilmour, Kimberly Jackson, Richard Ashmore, Catherine Evans, Sharon Rocha, Júlio Cesar Ilgaz, Fatma Hickson, Mary MacDonald, Anita |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Centro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS) Comprehensive Health Research Centre (CHRC) - pólo NMS RUN |
| dc.contributor.author.fl_str_mv |
Pinto, Alex Daly, Anne Newby, Camille Robotham, Abigail Heales, Simon Eaton, Simon Aitkenhead, Helen Gilmour, Kimberly Jackson, Richard Ashmore, Catherine Evans, Sharon Rocha, Júlio Cesar Ilgaz, Fatma Hickson, Mary MacDonald, Anita |
| dc.subject.por.fl_str_mv |
Amino acids Gastrointestinal symptoms Glycomacropeptide Gut health Inflammation Oxidative stress Phenylketonuria Renal function Satiety Endocrinology, Diabetes and Metabolism Biochemistry Molecular Biology Genetics Endocrinology SDG 3 - Good Health and Well-being |
| topic |
Amino acids Gastrointestinal symptoms Glycomacropeptide Gut health Inflammation Oxidative stress Phenylketonuria Renal function Satiety Endocrinology, Diabetes and Metabolism Biochemistry Molecular Biology Genetics Endocrinology SDG 3 - Good Health and Well-being |
| description |
Funding Information: This study was sponsored by Vitaflo International Ltd.\u00AE, UK and Arla Foods Ingredients Group P/S. Publisher Copyright: © 2024 |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024-12-18T17:24:44Z 2024-12 2024-12-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/176461 |
| url |
http://hdl.handle.net/10362/176461 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
1096-7192 PURE: 103804415 https://doi.org/10.1016/j.ymgme.2024.108607 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.source.none.fl_str_mv |
reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia instacron:RCAAP |
| instname_str |
FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia |
| instacron_str |
RCAAP |
| institution |
RCAAP |
| reponame_str |
Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| collection |
Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| repository.name.fl_str_mv |
Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia |
| repository.mail.fl_str_mv |
info@rcaap.pt |
| _version_ |
1833598022645186560 |