Association between common cardiovascular risk factors and clinical phenotype in patients with hypertrophic cardiomyopathy from the European Society of Cardiology (ESC) EurObservational Research Programme (EORP) Cardiomyopathy/Myocarditis registry
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| Publication Date: | 2022 |
| Other Authors: | , , , , , , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Download full: | http://hdl.handle.net/10451/55209 |
Summary: | © The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
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Association between common cardiovascular risk factors and clinical phenotype in patients with hypertrophic cardiomyopathy from the European Society of Cardiology (ESC) EurObservational Research Programme (EORP) Cardiomyopathy/Myocarditis registryCardiovascular risk factorsDiabetesGenotypeHypertensionHypertrophic cardiomyopathyObesity© The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.Aims: The interaction between common cardiovascular risk factors (CVRF) and hypertrophic cardiomyopathy (HCM) is poorly studied. We sought to explore the relation between CVRF and the clinical characteristics of patients with HCM enrolled in the EURObservational Research Programme (EORP) Cardiomyopathy registry. Methods and results: 1739 patients with HCM were studied. The relation between hypertension (HT), diabetes (DM), body mass index (BMI) and clinical traits was analyzed. Analyses were stratified according to the presence or absence of a pathogenic variant in a sarcomere gene.The prevalence of HT, DM and obesity (Ob) was 37%, 10%, and 21%, respectively. HT, DM and Ob were associated with older age (p<0.001), less family history of HCM (HT and DM p<0.001), higher New York Heart Association (NYHA) class (p<0.001), atrial fibrillation (HT and DM p<0.001; Ob p = 0.03) and LV (left ventricular) diastolic dysfunction (HT and Ob p<0.001; DM p = 0.003). Stroke was more frequent in HT (p<0.001) and mutation-positive patients with DM (p = 0.02). HT and Ob were associated with higher provocable LV outflow tract gradients (HT p<0.001, Ob p = 0.036). LV hypertrophy was more severe in Ob (p = 0.018). HT and Ob were independently associated with NYHA class (OR 1.419, p = 0.017 and OR 1.584, p = 0.004, respectively). Other associations, including a higher proportion of females in HT and of systolic dysfunction in HT and Ob, were observed only in mutation-positive patients. Conclusion: Common CVRF are associated with a more severe HCM phenotype, suggesting a proactive management of CVRF should be promoted. An interaction between genotype and CVRF was observed for some traits.Oxford University PressRepositório da Universidade de LisboaLopes, Luis R.Losi, Maria-AngelaSheikh, NabeelLaroche, CécileCharron, PhilippeGimeno, JuanKaski, Juan P.Maggioni, Aldo P.Tavazzi, LuigiArbustini, EloisaBrito, DulceCelutkiene, JelenaHagege, AlbertLinhart, AlesMogensen, JensGarcia-Pinilla, José ManuelRipoll-Vera, TomasSeggewiss, HubertVillacorta, EduardoCaforio, AlidaElliott, Perry M.2022-11-22T15:47:37Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/55209engEur Heart J Qual Care Clin Outcomes. 2022 Feb 9;qcac0062058-522510.1093/ehjqcco/qcac0062058-1742info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:51:14Zoai:repositorio.ulisboa.pt:10451/55209Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:26:48.197339Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
Association between common cardiovascular risk factors and clinical phenotype in patients with hypertrophic cardiomyopathy from the European Society of Cardiology (ESC) EurObservational Research Programme (EORP) Cardiomyopathy/Myocarditis registry |
| title |
Association between common cardiovascular risk factors and clinical phenotype in patients with hypertrophic cardiomyopathy from the European Society of Cardiology (ESC) EurObservational Research Programme (EORP) Cardiomyopathy/Myocarditis registry |
| spellingShingle |
Association between common cardiovascular risk factors and clinical phenotype in patients with hypertrophic cardiomyopathy from the European Society of Cardiology (ESC) EurObservational Research Programme (EORP) Cardiomyopathy/Myocarditis registry Lopes, Luis R. Cardiovascular risk factors Diabetes Genotype Hypertension Hypertrophic cardiomyopathy Obesity |
| title_short |
Association between common cardiovascular risk factors and clinical phenotype in patients with hypertrophic cardiomyopathy from the European Society of Cardiology (ESC) EurObservational Research Programme (EORP) Cardiomyopathy/Myocarditis registry |
| title_full |
Association between common cardiovascular risk factors and clinical phenotype in patients with hypertrophic cardiomyopathy from the European Society of Cardiology (ESC) EurObservational Research Programme (EORP) Cardiomyopathy/Myocarditis registry |
| title_fullStr |
Association between common cardiovascular risk factors and clinical phenotype in patients with hypertrophic cardiomyopathy from the European Society of Cardiology (ESC) EurObservational Research Programme (EORP) Cardiomyopathy/Myocarditis registry |
| title_full_unstemmed |
Association between common cardiovascular risk factors and clinical phenotype in patients with hypertrophic cardiomyopathy from the European Society of Cardiology (ESC) EurObservational Research Programme (EORP) Cardiomyopathy/Myocarditis registry |
| title_sort |
Association between common cardiovascular risk factors and clinical phenotype in patients with hypertrophic cardiomyopathy from the European Society of Cardiology (ESC) EurObservational Research Programme (EORP) Cardiomyopathy/Myocarditis registry |
| author |
Lopes, Luis R. |
| author_facet |
Lopes, Luis R. Losi, Maria-Angela Sheikh, Nabeel Laroche, Cécile Charron, Philippe Gimeno, Juan Kaski, Juan P. Maggioni, Aldo P. Tavazzi, Luigi Arbustini, Eloisa Brito, Dulce Celutkiene, Jelena Hagege, Albert Linhart, Ales Mogensen, Jens Garcia-Pinilla, José Manuel Ripoll-Vera, Tomas Seggewiss, Hubert Villacorta, Eduardo Caforio, Alida Elliott, Perry M. |
| author_role |
author |
| author2 |
Losi, Maria-Angela Sheikh, Nabeel Laroche, Cécile Charron, Philippe Gimeno, Juan Kaski, Juan P. Maggioni, Aldo P. Tavazzi, Luigi Arbustini, Eloisa Brito, Dulce Celutkiene, Jelena Hagege, Albert Linhart, Ales Mogensen, Jens Garcia-Pinilla, José Manuel Ripoll-Vera, Tomas Seggewiss, Hubert Villacorta, Eduardo Caforio, Alida Elliott, Perry M. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Lopes, Luis R. Losi, Maria-Angela Sheikh, Nabeel Laroche, Cécile Charron, Philippe Gimeno, Juan Kaski, Juan P. Maggioni, Aldo P. Tavazzi, Luigi Arbustini, Eloisa Brito, Dulce Celutkiene, Jelena Hagege, Albert Linhart, Ales Mogensen, Jens Garcia-Pinilla, José Manuel Ripoll-Vera, Tomas Seggewiss, Hubert Villacorta, Eduardo Caforio, Alida Elliott, Perry M. |
| dc.subject.por.fl_str_mv |
Cardiovascular risk factors Diabetes Genotype Hypertension Hypertrophic cardiomyopathy Obesity |
| topic |
Cardiovascular risk factors Diabetes Genotype Hypertension Hypertrophic cardiomyopathy Obesity |
| description |
© The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| publishDate |
2022 |
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2022-11-22T15:47:37Z 2022 2022-01-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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http://hdl.handle.net/10451/55209 |
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http://hdl.handle.net/10451/55209 |
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eng |
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eng |
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Eur Heart J Qual Care Clin Outcomes. 2022 Feb 9;qcac006 2058-5225 10.1093/ehjqcco/qcac006 2058-1742 |
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Oxford University Press |
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Oxford University Press |
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