Multimorbidity and frailty are associated with poorer SARS-CoV-2-related outcomes: systematic review of population-based studies

Bibliographic Details
Main Author: Makovski, Tatjana T.
Publication Date: 2024
Other Authors: Ghattas, Jinane, Monnier-Besnard, Stéphanie, Cavillot, Lisa, Ambrožová, Monika, Vašinová, Barbora, Feteira-Santos, Rodrigo, Bezzegh, Peter, Bollmann, Felipe Ponce, Cottam, James, Haneef, Romana, Devleesschauwer, Brecht, Speybroeck, Niko, Nogueira, Paulo Jorge, Forjaz, Maria João, Coste, Joël, Carcaillon-Bentata, Laure
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/65436
Summary: © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
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spelling Multimorbidity and frailty are associated with poorer SARS-CoV-2-related outcomes: systematic review of population-based studiesCOVID-19FrailtyMultimorbidityMultiple chronic conditionsSARS-CoV-2© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.Background: Estimating the risks and impacts of COVID-19 for different health groups at the population level is essential for orienting public health measures. Adopting a population-based approach, we conducted a systematic review to explore: (1) the etiological role of multimorbidity and frailty in developing SARS-CoV-2 infection and COVID-19-related short-term outcomes; and (2) the prognostic role of multimorbidity and frailty in developing short- and long-term outcomes. This review presents the state of the evidence in the early years of the pandemic. It was conducted within the European Union Horizon 2020 program (No: 101018317); Prospero registration: CRD42021249444. Methods: PubMed, Embase, World Health Organisation COVID-19 Global literature on coronavirus disease, and PsycINFO were searched between January 2020 and 7 April 2021 for multimorbidity and 1 February 2022 for frailty. Quantitative peer-reviewed studies published in English with population-representative samples and validated multimorbidity and frailty tools were considered. Results: Overall, 9,701 records were screened by title/abstract and 267 with full text. Finally, 14 studies were retained for multimorbidity (etiological role, n = 2; prognostic, n = 13) and 5 for frailty (etiological role, n = 2; prognostic, n = 4). Only short-term outcomes, mainly mortality, were identified. An elevated likelihood of poorer outcomes was associated with an increasing number of diseases, a higher Charlson Comorbidity Index, different disease combinations, and an increasing frailty level. Discussion: Future studies, which include the effects of recent virus variants, repeated exposure and vaccination, will be useful for comparing the possible evolution of the associations observed in the earlier waves.The study was performed as part of the Population Health Information Research Infrastructure (PHIRI) project funded by the European Union’s (EU) Horizon 2020 research and innovation program under the grant agreement no. 101018317 (available from: https://cordis.europa.eu/project/id/101018317).Springer NatureRepositório da Universidade de LisboaMakovski, Tatjana T.Ghattas, JinaneMonnier-Besnard, StéphanieCavillot, LisaAmbrožová, MonikaVašinová, BarboraFeteira-Santos, RodrigoBezzegh, PeterBollmann, Felipe PonceCottam, JamesHaneef, RomanaDevleesschauwer, BrechtSpeybroeck, NikoNogueira, Paulo JorgeForjaz, Maria JoãoCoste, JoëlCarcaillon-Bentata, Laure2024-07-24T11:12:54Z20242024-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/65436engAging Clin Exp Res. 2024 Feb 14;36(1):401594-066710.1007/s40520-023-02685-41720-8319info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T15:16:53Zoai:repositorio.ulisboa.pt:10451/65436Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:38:59.514917Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Multimorbidity and frailty are associated with poorer SARS-CoV-2-related outcomes: systematic review of population-based studies
title Multimorbidity and frailty are associated with poorer SARS-CoV-2-related outcomes: systematic review of population-based studies
spellingShingle Multimorbidity and frailty are associated with poorer SARS-CoV-2-related outcomes: systematic review of population-based studies
Makovski, Tatjana T.
COVID-19
Frailty
Multimorbidity
Multiple chronic conditions
SARS-CoV-2
title_short Multimorbidity and frailty are associated with poorer SARS-CoV-2-related outcomes: systematic review of population-based studies
title_full Multimorbidity and frailty are associated with poorer SARS-CoV-2-related outcomes: systematic review of population-based studies
title_fullStr Multimorbidity and frailty are associated with poorer SARS-CoV-2-related outcomes: systematic review of population-based studies
title_full_unstemmed Multimorbidity and frailty are associated with poorer SARS-CoV-2-related outcomes: systematic review of population-based studies
title_sort Multimorbidity and frailty are associated with poorer SARS-CoV-2-related outcomes: systematic review of population-based studies
author Makovski, Tatjana T.
author_facet Makovski, Tatjana T.
Ghattas, Jinane
Monnier-Besnard, Stéphanie
Cavillot, Lisa
Ambrožová, Monika
Vašinová, Barbora
Feteira-Santos, Rodrigo
Bezzegh, Peter
Bollmann, Felipe Ponce
Cottam, James
Haneef, Romana
Devleesschauwer, Brecht
Speybroeck, Niko
Nogueira, Paulo Jorge
Forjaz, Maria João
Coste, Joël
Carcaillon-Bentata, Laure
author_role author
author2 Ghattas, Jinane
Monnier-Besnard, Stéphanie
Cavillot, Lisa
Ambrožová, Monika
Vašinová, Barbora
Feteira-Santos, Rodrigo
Bezzegh, Peter
Bollmann, Felipe Ponce
Cottam, James
Haneef, Romana
Devleesschauwer, Brecht
Speybroeck, Niko
Nogueira, Paulo Jorge
Forjaz, Maria João
Coste, Joël
Carcaillon-Bentata, Laure
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Makovski, Tatjana T.
Ghattas, Jinane
Monnier-Besnard, Stéphanie
Cavillot, Lisa
Ambrožová, Monika
Vašinová, Barbora
Feteira-Santos, Rodrigo
Bezzegh, Peter
Bollmann, Felipe Ponce
Cottam, James
Haneef, Romana
Devleesschauwer, Brecht
Speybroeck, Niko
Nogueira, Paulo Jorge
Forjaz, Maria João
Coste, Joël
Carcaillon-Bentata, Laure
dc.subject.por.fl_str_mv COVID-19
Frailty
Multimorbidity
Multiple chronic conditions
SARS-CoV-2
topic COVID-19
Frailty
Multimorbidity
Multiple chronic conditions
SARS-CoV-2
description © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
publishDate 2024
dc.date.none.fl_str_mv 2024-07-24T11:12:54Z
2024
2024-01-01T00:00:00Z
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dc.relation.none.fl_str_mv Aging Clin Exp Res. 2024 Feb 14;36(1):40
1594-0667
10.1007/s40520-023-02685-4
1720-8319
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