Caffeine and adenosine

Bibliographic Details
Main Author: Ribeiro, Joaquim A.
Publication Date: 2010
Other Authors: Sebastião, Ana M
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/6361
Summary: © 2010 – IOS Press and the authors. All rights reserved
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spelling Caffeine and adenosineAdenosineAlzheimer’s diseaseHuntington’s diseaseParkinson’s diseaseSchizophreniaCognition© 2010 – IOS Press and the authors. All rights reservedCaffeine causes most of its biological effects via antagonizing all types of adenosine receptors (ARs): A1, A2A, A3, and A2B and, as does adenosine, exerts effects on neurons and glial cells of all brain areas. In consequence, caffeine, when acting as an AR antagonist, is doing the opposite of activation of adenosine receptors due to removal of endogenous adenosinergic tonus. Besides AR antagonism, xanthines, including caffeine, have other biological actions: they inhibit phosphodiesterases (PDEs) (e.g., PDE1, PDE4, PDE5), promote calcium release from intracellular stores, and interfere with GABA-A receptors. Caffeine, through antagonism of ARs, affects brain functions such as sleep, cognition, learning, and memory, and modifies brain dysfunctions and diseases: Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, Epilepsy, Pain/Migraine, Depression, Schizophrenia. In conclusion, targeting approaches that involve ARs will enhance the possibilities to correct brain dysfunctions, via the universally consumed substance that is caffeine.The work in the authors’ laboratory is supported by research grants from Fundação para a Ciência e Tecnologia (FCT), Gulbenkian Foundation and European Union (COST B30).IOS PressRepositório da Universidade de LisboaRibeiro, Joaquim A.Sebastião, Ana M2012-05-23T11:25:38Z20102010-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/6361engJournal of Alzheimer’s Disease 20 (2010) S3–S151387-2877info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T12:53:16Zoai:repositorio.ulisboa.pt:10451/6361Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T02:30:12.434663Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Caffeine and adenosine
title Caffeine and adenosine
spellingShingle Caffeine and adenosine
Ribeiro, Joaquim A.
Adenosine
Alzheimer’s disease
Huntington’s disease
Parkinson’s disease
Schizophrenia
Cognition
title_short Caffeine and adenosine
title_full Caffeine and adenosine
title_fullStr Caffeine and adenosine
title_full_unstemmed Caffeine and adenosine
title_sort Caffeine and adenosine
author Ribeiro, Joaquim A.
author_facet Ribeiro, Joaquim A.
Sebastião, Ana M
author_role author
author2 Sebastião, Ana M
author2_role author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Ribeiro, Joaquim A.
Sebastião, Ana M
dc.subject.por.fl_str_mv Adenosine
Alzheimer’s disease
Huntington’s disease
Parkinson’s disease
Schizophrenia
Cognition
topic Adenosine
Alzheimer’s disease
Huntington’s disease
Parkinson’s disease
Schizophrenia
Cognition
description © 2010 – IOS Press and the authors. All rights reserved
publishDate 2010
dc.date.none.fl_str_mv 2010
2010-01-01T00:00:00Z
2012-05-23T11:25:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/6361
url http://hdl.handle.net/10451/6361
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Alzheimer’s Disease 20 (2010) S3–S15
1387-2877
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv IOS Press
publisher.none.fl_str_mv IOS Press
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833601385866723328

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