Chronic Intermittent Hypoxia-Induced Dysmetabolism Is Associated with Hepatic Oxidative Stress, Mitochondrial Dysfunction and Inflammation

Bibliographic Details
Main Author: Fernandes, Joana L.
Publication Date: 2023
Other Authors: Martins, Fátima O., Olea, Elena, Prieto-Lloret, Jesus, Braga, Patrícia C., Sacramento, Joana F., Sequeira, Catarina O., Negrinho, Ana P., Pereira, Sofia A., Alves, Marco G., Rocher, Asunción, V Conde, Silvia
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/161759
Summary: CCVC8485 from Junta de Castilla y Leon, Spain. F.O.M., J.F.S. and M.G.A. are supported with CEEC contracts from the Portuguese Foundation for Science and Technology (CEECIND/04266/2017, CEEC IND/02428/2018 and 2021.03439.CEECIND, respectively). This work was also supported by Fundação para a Ciência e a Tecnologia”—FCT IBIMED (UIDP/04501/2020 and UIDB/04501/2020), UMIB (UIDB/00215/2020, and UIDP/00215/2020), ITR—Laboratory for Integrative and Translational Research in Population Health (LA/P/0064/2020), for the PhD student Patrícia C. Braga (UI/BD/150750/2020). Publisher Copyright: © 2023 by the authors.
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spelling Chronic Intermittent Hypoxia-Induced Dysmetabolism Is Associated with Hepatic Oxidative Stress, Mitochondrial Dysfunction and Inflammationchronic intermittent hypoxiainflammationinsulin resistancemetabolic disordersmitochondrial dysfunctionobstructive sleep apneaoxidative stressFood SciencePhysiologyBiochemistryMolecular BiologyClinical BiochemistryCell BiologyCCVC8485 from Junta de Castilla y Leon, Spain. F.O.M., J.F.S. and M.G.A. are supported with CEEC contracts from the Portuguese Foundation for Science and Technology (CEECIND/04266/2017, CEEC IND/02428/2018 and 2021.03439.CEECIND, respectively). This work was also supported by Fundação para a Ciência e a Tecnologia”—FCT IBIMED (UIDP/04501/2020 and UIDB/04501/2020), UMIB (UIDB/00215/2020, and UIDP/00215/2020), ITR—Laboratory for Integrative and Translational Research in Population Health (LA/P/0064/2020), for the PhD student Patrícia C. Braga (UI/BD/150750/2020). Publisher Copyright: © 2023 by the authors.The association between obstructive sleep apnea (OSA) and metabolic disorders is well-established; however, the underlying mechanisms that elucidate this relationship remain incompletely understood. Since the liver is a major organ in the maintenance of metabolic homeostasis, we hypothesize that liver dysfunction plays a crucial role in the pathogenesis of metabolic dysfunction associated with obstructive sleep apnea (OSA). Herein, we explored the underlying mechanisms of this association within the liver. Experiments were performed in male Wistar rats fed with a control or high fat (HF) diet (60% lipid-rich) for 12 weeks. Half of the groups were exposed to chronic intermittent hypoxia (CIH) (30 hypoxic (5% O2) cycles, 8 h/day) that mimics OSA, in the last 15 days. Insulin sensitivity and glucose tolerance were assessed. Liver samples were collected for evaluation of lipid deposition, insulin signaling, glucose homeostasis, hypoxia, oxidative stress, antioxidant defenses, mitochondrial biogenesis and inflammation. Both the CIH and HF diet induced dysmetabolism, a state not aggravated in animals submitted to HF plus CIH. CIH aggravates hepatic lipid deposition in obese animals. Hypoxia-inducible factors levels were altered by these stimuli. CIH decreased the levels of oxidative phosphorylation complexes in both groups and the levels of SOD-1. The HF diet reduced mitochondrial density and hepatic antioxidant capacity. The CIH and HF diet produced alterations in cysteine-related thiols and pro-inflammatory markers. The results obtained suggest that hepatic mitochondrial dysfunction and oxidative stress, leading to inflammation, may be significant factors contributing to the development of dysmetabolism associated with OSA.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)iNOVA4Health - pólo NMSRUNFernandes, Joana L.Martins, Fátima O.Olea, ElenaPrieto-Lloret, JesusBraga, Patrícia C.Sacramento, Joana F.Sequeira, Catarina O.Negrinho, Ana P.Pereira, Sofia A.Alves, Marco G.Rocher, AsunciónV Conde, Silvia2023-12-29T22:32:32Z2023-112023-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/161759eng2076-3921PURE: 78177086https://doi.org/10.3390/antiox12111910info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-05-26T01:41:01Zoai:run.unl.pt:10362/161759Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:47:43.889508Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Chronic Intermittent Hypoxia-Induced Dysmetabolism Is Associated with Hepatic Oxidative Stress, Mitochondrial Dysfunction and Inflammation
title Chronic Intermittent Hypoxia-Induced Dysmetabolism Is Associated with Hepatic Oxidative Stress, Mitochondrial Dysfunction and Inflammation
spellingShingle Chronic Intermittent Hypoxia-Induced Dysmetabolism Is Associated with Hepatic Oxidative Stress, Mitochondrial Dysfunction and Inflammation
Fernandes, Joana L.
chronic intermittent hypoxia
inflammation
insulin resistance
metabolic disorders
mitochondrial dysfunction
obstructive sleep apnea
oxidative stress
Food Science
Physiology
Biochemistry
Molecular Biology
Clinical Biochemistry
Cell Biology
title_short Chronic Intermittent Hypoxia-Induced Dysmetabolism Is Associated with Hepatic Oxidative Stress, Mitochondrial Dysfunction and Inflammation
title_full Chronic Intermittent Hypoxia-Induced Dysmetabolism Is Associated with Hepatic Oxidative Stress, Mitochondrial Dysfunction and Inflammation
title_fullStr Chronic Intermittent Hypoxia-Induced Dysmetabolism Is Associated with Hepatic Oxidative Stress, Mitochondrial Dysfunction and Inflammation
title_full_unstemmed Chronic Intermittent Hypoxia-Induced Dysmetabolism Is Associated with Hepatic Oxidative Stress, Mitochondrial Dysfunction and Inflammation
title_sort Chronic Intermittent Hypoxia-Induced Dysmetabolism Is Associated with Hepatic Oxidative Stress, Mitochondrial Dysfunction and Inflammation
author Fernandes, Joana L.
author_facet Fernandes, Joana L.
Martins, Fátima O.
Olea, Elena
Prieto-Lloret, Jesus
Braga, Patrícia C.
Sacramento, Joana F.
Sequeira, Catarina O.
Negrinho, Ana P.
Pereira, Sofia A.
Alves, Marco G.
Rocher, Asunción
V Conde, Silvia
author_role author
author2 Martins, Fátima O.
Olea, Elena
Prieto-Lloret, Jesus
Braga, Patrícia C.
Sacramento, Joana F.
Sequeira, Catarina O.
Negrinho, Ana P.
Pereira, Sofia A.
Alves, Marco G.
Rocher, Asunción
V Conde, Silvia
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
iNOVA4Health - pólo NMS
RUN
dc.contributor.author.fl_str_mv Fernandes, Joana L.
Martins, Fátima O.
Olea, Elena
Prieto-Lloret, Jesus
Braga, Patrícia C.
Sacramento, Joana F.
Sequeira, Catarina O.
Negrinho, Ana P.
Pereira, Sofia A.
Alves, Marco G.
Rocher, Asunción
V Conde, Silvia
dc.subject.por.fl_str_mv chronic intermittent hypoxia
inflammation
insulin resistance
metabolic disorders
mitochondrial dysfunction
obstructive sleep apnea
oxidative stress
Food Science
Physiology
Biochemistry
Molecular Biology
Clinical Biochemistry
Cell Biology
topic chronic intermittent hypoxia
inflammation
insulin resistance
metabolic disorders
mitochondrial dysfunction
obstructive sleep apnea
oxidative stress
Food Science
Physiology
Biochemistry
Molecular Biology
Clinical Biochemistry
Cell Biology
description CCVC8485 from Junta de Castilla y Leon, Spain. F.O.M., J.F.S. and M.G.A. are supported with CEEC contracts from the Portuguese Foundation for Science and Technology (CEECIND/04266/2017, CEEC IND/02428/2018 and 2021.03439.CEECIND, respectively). This work was also supported by Fundação para a Ciência e a Tecnologia”—FCT IBIMED (UIDP/04501/2020 and UIDB/04501/2020), UMIB (UIDB/00215/2020, and UIDP/00215/2020), ITR—Laboratory for Integrative and Translational Research in Population Health (LA/P/0064/2020), for the PhD student Patrícia C. Braga (UI/BD/150750/2020). Publisher Copyright: © 2023 by the authors.
publishDate 2023
dc.date.none.fl_str_mv 2023-12-29T22:32:32Z
2023-11
2023-11-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/161759
url http://hdl.handle.net/10362/161759
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2076-3921
PURE: 78177086
https://doi.org/10.3390/antiox12111910
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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