Fibroblast growth factor signaling in axons: from development to disease

Detalhes bibliográficos
Autor(a) principal: Tomé, Diogo
Data de Publicação: 2023
Outros Autores: Dias, Marta S., Correia, Joana, Almeida, Ramiro D.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: https://hdl.handle.net/10316/111759
https://doi.org/10.1186/s12964-023-01284-0
Resumo: The fibroblast growth factor (FGF) family regulates various and important aspects of nervous system development, ranging from the well-established roles in neuronal patterning to more recent and exciting functions in axonal growth and synaptogenesis. In addition, FGFs play a critical role in axonal regeneration, particularly after spinal cord injury, confirming their versatile nature in the nervous system. Due to their widespread involvement in neural development, the FGF system also underlies several human neurological disorders. While particular attention has been given to FGFs in a whole-cell context, their effects at the axonal level are in most cases undervalued. Here we discuss the endeavor of the FGF system in axons, we delve into this neuronal subcompartment to provide an original view of this multipurpose family of growth factors in nervous system (dys)function. Video Abstract.
id RCAP_7aa7bc87fed28523bb609db4ab4348d0
oai_identifier_str oai:estudogeral.uc.pt:10316/111759
network_acronym_str RCAP
network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository_id_str https://opendoar.ac.uk/repository/7160
spelling Fibroblast growth factor signaling in axons: from development to diseaseFGFSignaling pathwaysAxonsPresynaptic terminalAxonal injuryNeuronal disordersHumansNeuronsNeurogenesisSignal TransductionFibroblast Growth FactorsAxonsThe fibroblast growth factor (FGF) family regulates various and important aspects of nervous system development, ranging from the well-established roles in neuronal patterning to more recent and exciting functions in axonal growth and synaptogenesis. In addition, FGFs play a critical role in axonal regeneration, particularly after spinal cord injury, confirming their versatile nature in the nervous system. Due to their widespread involvement in neural development, the FGF system also underlies several human neurological disorders. While particular attention has been given to FGFs in a whole-cell context, their effects at the axonal level are in most cases undervalued. Here we discuss the endeavor of the FGF system in axons, we delve into this neuronal subcompartment to provide an original view of this multipurpose family of growth factors in nervous system (dys)function. Video Abstract.Signal Transduction Society2023-10-16info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://hdl.handle.net/10316/111759https://hdl.handle.net/10316/111759https://doi.org/10.1186/s12964-023-01284-0eng1478-811XTomé, DiogoDias, Marta S.Correia, JoanaAlmeida, Ramiro D.info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-06-13T13:00:06Zoai:estudogeral.uc.pt:10316/111759Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T06:04:05.427362Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Fibroblast growth factor signaling in axons: from development to disease
title Fibroblast growth factor signaling in axons: from development to disease
spellingShingle Fibroblast growth factor signaling in axons: from development to disease
Tomé, Diogo
FGF
Signaling pathways
Axons
Presynaptic terminal
Axonal injury
Neuronal disorders
Humans
Neurons
Neurogenesis
Signal Transduction
Fibroblast Growth Factors
Axons
title_short Fibroblast growth factor signaling in axons: from development to disease
title_full Fibroblast growth factor signaling in axons: from development to disease
title_fullStr Fibroblast growth factor signaling in axons: from development to disease
title_full_unstemmed Fibroblast growth factor signaling in axons: from development to disease
title_sort Fibroblast growth factor signaling in axons: from development to disease
author Tomé, Diogo
author_facet Tomé, Diogo
Dias, Marta S.
Correia, Joana
Almeida, Ramiro D.
author_role author
author2 Dias, Marta S.
Correia, Joana
Almeida, Ramiro D.
author2_role author
author
author
dc.contributor.author.fl_str_mv Tomé, Diogo
Dias, Marta S.
Correia, Joana
Almeida, Ramiro D.
dc.subject.por.fl_str_mv FGF
Signaling pathways
Axons
Presynaptic terminal
Axonal injury
Neuronal disorders
Humans
Neurons
Neurogenesis
Signal Transduction
Fibroblast Growth Factors
Axons
topic FGF
Signaling pathways
Axons
Presynaptic terminal
Axonal injury
Neuronal disorders
Humans
Neurons
Neurogenesis
Signal Transduction
Fibroblast Growth Factors
Axons
description The fibroblast growth factor (FGF) family regulates various and important aspects of nervous system development, ranging from the well-established roles in neuronal patterning to more recent and exciting functions in axonal growth and synaptogenesis. In addition, FGFs play a critical role in axonal regeneration, particularly after spinal cord injury, confirming their versatile nature in the nervous system. Due to their widespread involvement in neural development, the FGF system also underlies several human neurological disorders. While particular attention has been given to FGFs in a whole-cell context, their effects at the axonal level are in most cases undervalued. Here we discuss the endeavor of the FGF system in axons, we delve into this neuronal subcompartment to provide an original view of this multipurpose family of growth factors in nervous system (dys)function. Video Abstract.
publishDate 2023
dc.date.none.fl_str_mv 2023-10-16
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10316/111759
https://hdl.handle.net/10316/111759
https://doi.org/10.1186/s12964-023-01284-0
url https://hdl.handle.net/10316/111759
https://doi.org/10.1186/s12964-023-01284-0
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1478-811X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Signal Transduction Society
publisher.none.fl_str_mv Signal Transduction Society
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833602565345902592

Registros relacionados