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Enhancing cannabidiol bioaccessibility using ionic liquid as emulsifier to produce nanosystems: Characterization of structures, cytotoxicity assessment, and in vitro digestion

Bibliographic Details
Main Author: Vardanega, Renata
Publication Date: 2024
Other Authors: Lüdtke, Fernanda Luisa, Loureiro, Luís Carlos Sá, Hijo, Ariel A. C. Toledo, Martins, Joana T., Pinheiro, A. C., Vicente, A. A.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://hdl.handle.net/1822/91722
Summary: The emulsifying potential of a biocompatible ionic liquid (IL) to produce lipid-based nanosystems developed to enhance the bioaccessibility of cannabidiol (CBD) was investigated. The IL (cholinium oleate) was evaluated at concentrations of 1 % and 2 % to produce nanoemulsions (NE-IL) and nanostructured lipid carriers (NLC-IL) loaded with CBD. The IL concentration of 1 % demonstrated to be sufficient to produce both NE-IL and NLC-IL with excellent stability properties, entrapment efficiency superior to 99 %, and CBD retention rate of 100 % during the storage period evaluated (i.e. 28 days at 25 °C). The in vitro digestion evaluation demonstrated that the NLC-IL provided a higher stability to the CBD, while the NE-IL improved the CBD bioaccessibility, which was mainly related to the composition of the lipid matrices used to obtain each nanosystem. Finally, it was observed that the CBD cytotoxicity was reduced when the compound was entrapped into both nanosystems.
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spelling Enhancing cannabidiol bioaccessibility using ionic liquid as emulsifier to produce nanosystems: Characterization of structures, cytotoxicity assessment, and in vitro digestionCholinium oleateCannabinoidsNanoemulsionNanostructured lipid carrierLipid-based systemsStabilityNanoemulsion, nanostructured lipid carrierThe emulsifying potential of a biocompatible ionic liquid (IL) to produce lipid-based nanosystems developed to enhance the bioaccessibility of cannabidiol (CBD) was investigated. The IL (cholinium oleate) was evaluated at concentrations of 1 % and 2 % to produce nanoemulsions (NE-IL) and nanostructured lipid carriers (NLC-IL) loaded with CBD. The IL concentration of 1 % demonstrated to be sufficient to produce both NE-IL and NLC-IL with excellent stability properties, entrapment efficiency superior to 99 %, and CBD retention rate of 100 % during the storage period evaluated (i.e. 28 days at 25 °C). The in vitro digestion evaluation demonstrated that the NLC-IL provided a higher stability to the CBD, while the NE-IL improved the CBD bioaccessibility, which was mainly related to the composition of the lipid matrices used to obtain each nanosystem. Finally, it was observed that the CBD cytotoxicity was reduced when the compound was entrapped into both nanosystems.FCT -Fundação para a Ciência e a Tecnologia(2019/18608-1)info:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoVardanega, RenataLüdtke, Fernanda LuisaLoureiro, Luís Carlos SáHijo, Ariel A. C. ToledoMartins, Joana T.Pinheiro, A. C.Vicente, A. A.2024-072024-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/91722engVardanega, Renata; Lüdtke, Fernanda Luisa; Luís Loureiro; Hijo, Ariel; Martins, Joana T.; Pinheiro, Ana Cristina; Vicente, António A., Enhancing cannabidiol bioaccessibility using ionic liquid as emulsifier to produce nanosystems: Characterization of structures, cytotoxicity assessment, and in vitro digestion. Food Research International, 188(114498), 20240963-996910.1016/j.foodres.2024.11449838823878http://www.journals.elsevier.com/food-research-international/info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-04-12T05:27:28Zoai:repositorium.sdum.uminho.pt:1822/91722Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:54:45.834879Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Enhancing cannabidiol bioaccessibility using ionic liquid as emulsifier to produce nanosystems: Characterization of structures, cytotoxicity assessment, and in vitro digestion
title Enhancing cannabidiol bioaccessibility using ionic liquid as emulsifier to produce nanosystems: Characterization of structures, cytotoxicity assessment, and in vitro digestion
spellingShingle Enhancing cannabidiol bioaccessibility using ionic liquid as emulsifier to produce nanosystems: Characterization of structures, cytotoxicity assessment, and in vitro digestion
Vardanega, Renata
Cholinium oleate
Cannabinoids
Nanoemulsion
Nanostructured lipid carrier
Lipid-based systems
Stability
Nanoemulsion, nanostructured lipid carrier
title_short Enhancing cannabidiol bioaccessibility using ionic liquid as emulsifier to produce nanosystems: Characterization of structures, cytotoxicity assessment, and in vitro digestion
title_full Enhancing cannabidiol bioaccessibility using ionic liquid as emulsifier to produce nanosystems: Characterization of structures, cytotoxicity assessment, and in vitro digestion
title_fullStr Enhancing cannabidiol bioaccessibility using ionic liquid as emulsifier to produce nanosystems: Characterization of structures, cytotoxicity assessment, and in vitro digestion
title_full_unstemmed Enhancing cannabidiol bioaccessibility using ionic liquid as emulsifier to produce nanosystems: Characterization of structures, cytotoxicity assessment, and in vitro digestion
title_sort Enhancing cannabidiol bioaccessibility using ionic liquid as emulsifier to produce nanosystems: Characterization of structures, cytotoxicity assessment, and in vitro digestion
author Vardanega, Renata
author_facet Vardanega, Renata
Lüdtke, Fernanda Luisa
Loureiro, Luís Carlos Sá
Hijo, Ariel A. C. Toledo
Martins, Joana T.
Pinheiro, A. C.
Vicente, A. A.
author_role author
author2 Lüdtke, Fernanda Luisa
Loureiro, Luís Carlos Sá
Hijo, Ariel A. C. Toledo
Martins, Joana T.
Pinheiro, A. C.
Vicente, A. A.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Vardanega, Renata
Lüdtke, Fernanda Luisa
Loureiro, Luís Carlos Sá
Hijo, Ariel A. C. Toledo
Martins, Joana T.
Pinheiro, A. C.
Vicente, A. A.
dc.subject.por.fl_str_mv Cholinium oleate
Cannabinoids
Nanoemulsion
Nanostructured lipid carrier
Lipid-based systems
Stability
Nanoemulsion, nanostructured lipid carrier
topic Cholinium oleate
Cannabinoids
Nanoemulsion
Nanostructured lipid carrier
Lipid-based systems
Stability
Nanoemulsion, nanostructured lipid carrier
description The emulsifying potential of a biocompatible ionic liquid (IL) to produce lipid-based nanosystems developed to enhance the bioaccessibility of cannabidiol (CBD) was investigated. The IL (cholinium oleate) was evaluated at concentrations of 1 % and 2 % to produce nanoemulsions (NE-IL) and nanostructured lipid carriers (NLC-IL) loaded with CBD. The IL concentration of 1 % demonstrated to be sufficient to produce both NE-IL and NLC-IL with excellent stability properties, entrapment efficiency superior to 99 %, and CBD retention rate of 100 % during the storage period evaluated (i.e. 28 days at 25 °C). The in vitro digestion evaluation demonstrated that the NLC-IL provided a higher stability to the CBD, while the NE-IL improved the CBD bioaccessibility, which was mainly related to the composition of the lipid matrices used to obtain each nanosystem. Finally, it was observed that the CBD cytotoxicity was reduced when the compound was entrapped into both nanosystems.
publishDate 2024
dc.date.none.fl_str_mv 2024-07
2024-07-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/91722
url https://hdl.handle.net/1822/91722
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Vardanega, Renata; Lüdtke, Fernanda Luisa; Luís Loureiro; Hijo, Ariel; Martins, Joana T.; Pinheiro, Ana Cristina; Vicente, António A., Enhancing cannabidiol bioaccessibility using ionic liquid as emulsifier to produce nanosystems: Characterization of structures, cytotoxicity assessment, and in vitro digestion. Food Research International, 188(114498), 2024
0963-9969
10.1016/j.foodres.2024.114498
38823878
http://www.journals.elsevier.com/food-research-international/
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833597052126232576

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