Population dynamics of centrosome amplification

Bibliographic Details
Main Author: Louro, Marco António Dias
Publication Date: 2024
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/169105
Summary: "Living organisms are fundamentally composed of cells and subject to evolutionary change. These are perhaps two of the most general concepts in biology. An integrative framework that encompasses both evolutionary and cell biology is necessary for understanding how cellular features change and diversify. Such a framework is crucial for understanding a plethora of phenomena, ranging from how cellular components expand and disappear across the tree of life to human disease. In this thesis, I make use of evolutionary and cell biological principles to address the causes and consequences of centriole number abnormalities.(...)"
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spelling Population dynamics of centrosome amplificationcentrosome amplificationmutation-selection balancecancerPlk4cell cycleDomínio/Área Científica::Ciências Naturais"Living organisms are fundamentally composed of cells and subject to evolutionary change. These are perhaps two of the most general concepts in biology. An integrative framework that encompasses both evolutionary and cell biology is necessary for understanding how cellular features change and diversify. Such a framework is crucial for understanding a plethora of phenomena, ranging from how cellular components expand and disappear across the tree of life to human disease. In this thesis, I make use of evolutionary and cell biological principles to address the causes and consequences of centriole number abnormalities.(...)"Bank, CláudiaBettencourt-Dias, MónicaRUNLouro, Marco António Dias2024-05-212024-022025-05-31T00:00:00Z2024-05-21T00:00:00Zdoctoral thesisinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10362/169105TID:101778783enginfo:eu-repo/semantics/embargoedAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-07-01T01:35:05Zoai:run.unl.pt:10362/169105Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:57:14.220368Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Population dynamics of centrosome amplification
title Population dynamics of centrosome amplification
spellingShingle Population dynamics of centrosome amplification
Louro, Marco António Dias
centrosome amplification
mutation-selection balance
cancer
Plk4
cell cycle
Domínio/Área Científica::Ciências Naturais
title_short Population dynamics of centrosome amplification
title_full Population dynamics of centrosome amplification
title_fullStr Population dynamics of centrosome amplification
title_full_unstemmed Population dynamics of centrosome amplification
title_sort Population dynamics of centrosome amplification
author Louro, Marco António Dias
author_facet Louro, Marco António Dias
author_role author
dc.contributor.none.fl_str_mv Bank, Cláudia
Bettencourt-Dias, Mónica
RUN
dc.contributor.author.fl_str_mv Louro, Marco António Dias
dc.subject.por.fl_str_mv centrosome amplification
mutation-selection balance
cancer
Plk4
cell cycle
Domínio/Área Científica::Ciências Naturais
topic centrosome amplification
mutation-selection balance
cancer
Plk4
cell cycle
Domínio/Área Científica::Ciências Naturais
description "Living organisms are fundamentally composed of cells and subject to evolutionary change. These are perhaps two of the most general concepts in biology. An integrative framework that encompasses both evolutionary and cell biology is necessary for understanding how cellular features change and diversify. Such a framework is crucial for understanding a plethora of phenomena, ranging from how cellular components expand and disappear across the tree of life to human disease. In this thesis, I make use of evolutionary and cell biological principles to address the causes and consequences of centriole number abnormalities.(...)"
publishDate 2024
dc.date.none.fl_str_mv 2024-05-21
2024-02
2024-05-21T00:00:00Z
2025-05-31T00:00:00Z
dc.type.driver.fl_str_mv doctoral thesis
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/169105
TID:101778783
url http://hdl.handle.net/10362/169105
identifier_str_mv TID:101778783
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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