Cysteine as a Carbon Source, a Hot Spot in Cancer Cells Survival

Bibliographic Details
Main Author: Serpa, Jacinta
Publication Date: 2020
Format: Other
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/100938
Summary: Cancer cells undergo a metabolic rewiring in order to fulfill the energy and biomass requirements. Cysteine is a pivotal organic compound that contributes for cancer metabolic remodeling at three different levels: (1) in redox control, free or as a component of glutathione; (2) in ATP production, via hydrogen sulfide (H2S) production, serving as a donor to electron transport chain (ETC), and (3) as a carbon source for biomass and energy production. In the present review, emphasis will be given to the role of cysteine as a carbon source, focusing on the metabolic reliance on cysteine, benefiting the metabolic fitness and survival of cancer cells. Therefore, the interplay between cysteine metabolism and other metabolic pathways, as well as the regulation of cysteine metabolism related enzymes and transporters, will be also addressed. Finally, the usefulness of cysteine metabolic route as a target in cancer treatment will be highlighted.
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spelling Cysteine as a Carbon Source, a Hot Spot in Cancer Cells Survivalcancer metabolic remodelingcysteinecysteine metabolismcysteine transporttargeting cysteine routeOncologyCancer ResearchSDG 3 - Good Health and Well-beingCancer cells undergo a metabolic rewiring in order to fulfill the energy and biomass requirements. Cysteine is a pivotal organic compound that contributes for cancer metabolic remodeling at three different levels: (1) in redox control, free or as a component of glutathione; (2) in ATP production, via hydrogen sulfide (H2S) production, serving as a donor to electron transport chain (ETC), and (3) as a carbon source for biomass and energy production. In the present review, emphasis will be given to the role of cysteine as a carbon source, focusing on the metabolic reliance on cysteine, benefiting the metabolic fitness and survival of cancer cells. Therefore, the interplay between cysteine metabolism and other metabolic pathways, as well as the regulation of cysteine metabolism related enzymes and transporters, will be also addressed. Finally, the usefulness of cysteine metabolic route as a target in cancer treatment will be highlighted.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNSerpa, Jacinta2020-07-15T23:10:42Z2020-06-232020-06-23T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://hdl.handle.net/10362/100938engPURE: 19061324https://doi.org/10.3389/fonc.2020.00947info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-10-21T01:36:01Zoai:run.unl.pt:10362/100938Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:17:37.883548Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Cysteine as a Carbon Source, a Hot Spot in Cancer Cells Survival
title Cysteine as a Carbon Source, a Hot Spot in Cancer Cells Survival
spellingShingle Cysteine as a Carbon Source, a Hot Spot in Cancer Cells Survival
Serpa, Jacinta
cancer metabolic remodeling
cysteine
cysteine metabolism
cysteine transport
targeting cysteine route
Oncology
Cancer Research
SDG 3 - Good Health and Well-being
title_short Cysteine as a Carbon Source, a Hot Spot in Cancer Cells Survival
title_full Cysteine as a Carbon Source, a Hot Spot in Cancer Cells Survival
title_fullStr Cysteine as a Carbon Source, a Hot Spot in Cancer Cells Survival
title_full_unstemmed Cysteine as a Carbon Source, a Hot Spot in Cancer Cells Survival
title_sort Cysteine as a Carbon Source, a Hot Spot in Cancer Cells Survival
author Serpa, Jacinta
author_facet Serpa, Jacinta
author_role author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv Serpa, Jacinta
dc.subject.por.fl_str_mv cancer metabolic remodeling
cysteine
cysteine metabolism
cysteine transport
targeting cysteine route
Oncology
Cancer Research
SDG 3 - Good Health and Well-being
topic cancer metabolic remodeling
cysteine
cysteine metabolism
cysteine transport
targeting cysteine route
Oncology
Cancer Research
SDG 3 - Good Health and Well-being
description Cancer cells undergo a metabolic rewiring in order to fulfill the energy and biomass requirements. Cysteine is a pivotal organic compound that contributes for cancer metabolic remodeling at three different levels: (1) in redox control, free or as a component of glutathione; (2) in ATP production, via hydrogen sulfide (H2S) production, serving as a donor to electron transport chain (ETC), and (3) as a carbon source for biomass and energy production. In the present review, emphasis will be given to the role of cysteine as a carbon source, focusing on the metabolic reliance on cysteine, benefiting the metabolic fitness and survival of cancer cells. Therefore, the interplay between cysteine metabolism and other metabolic pathways, as well as the regulation of cysteine metabolism related enzymes and transporters, will be also addressed. Finally, the usefulness of cysteine metabolic route as a target in cancer treatment will be highlighted.
publishDate 2020
dc.date.none.fl_str_mv 2020-07-15T23:10:42Z
2020-06-23
2020-06-23T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/100938
url http://hdl.handle.net/10362/100938
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv PURE: 19061324
https://doi.org/10.3389/fonc.2020.00947
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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