Changes in Glycolytic Pathway in SARS-COV 2 Infection and Their Importance in Understanding the Severity of COVID-19

Bibliographic Details
Main Author: Santos, Adalberto Fernandes
Publication Date: 2021
Other Authors: Povoa, Pedro, Paixão, Paulo, Mendonça, António, Taborda-Barata, Luís
Format: Other
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/126487
Summary: Publisher Copyright: © Copyright © 2021 Santos, Póvoa, Paixão, Mendonça and Taborda-Barata.
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spelling Changes in Glycolytic Pathway in SARS-COV 2 Infection and Their Importance in Understanding the Severity of COVID-19COVID-19glycolytic pathwayhyperglycolysisoxidative phosphorylationreactive oxygen speciesChemistry(all)SDG 3 - Good Health and Well-beingPublisher Copyright: © Copyright © 2021 Santos, Póvoa, Paixão, Mendonça and Taborda-Barata.COVID-19 is an infectious disease caused by Coronavirus 2 (SARS-CoV-2) that may lead to a severe acute respiratory syndrome. Such syndrome is thought to be related, at least in part, to a dysregulation of the immune system which involves three main components: hyperactivity of the innate immune system; decreased production of type 1 Interferons (IFN) by SARS-CoV-2-infected cells, namely respiratory epithelial cells and macrophages; and decreased numbers of both CD4+ and particularly CD8+ T cells. Herein, we describe how excessive activation of the innate immune system and the need for viral replication in several cells of the infected organism promote significant alterations in cells’ energy metabolism (glucose metabolism), which may underlie the poor prognosis of the disease in severe situations. When activated, cells of the innate immune system reprogram their metabolism, and increase glucose uptake to ensure secretion of pro-inflammatory cytokines. Changes in glucose metabolism are also observed in pulmonary epithelial cells, contributing to dysregulation of cytokine synthesis and inflammation of the pulmonary epithelium. Controlling hyperglycolysis in critically ill patients may help to reduce the exaggerated production of pro-inflammatory cytokines and optimise the actions of the adaptive immune system. In this review, we suggest that the administration of non-toxic concentrations of 2-deoxy-D-glucose, the use of GLUT 1 inhibitors, of antioxidants such as vitamin C in high doses, as well as the administration of N-acetylcysteine in high doses, may be useful complementary therapeutic strategies for these patients, as suggested by some clinical trials and/ or reports. Overall, understanding changes in the glycolytic pathway associated with COVID-19 infection can help to find new forms of treatment for this disease.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Comprehensive Health Research Centre (CHRC) - pólo NMSRUNSantos, Adalberto FernandesPovoa, PedroPaixão, PauloMendonça, AntónioTaborda-Barata, Luís2021-10-22T03:43:14Z2021-09-102021-09-10T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://hdl.handle.net/10362/126487eng2296-2646PURE: 34203711https://doi.org/10.3389/fchem.2021.685196info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:56:46Zoai:run.unl.pt:10362/126487Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:27:50.047239Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Changes in Glycolytic Pathway in SARS-COV 2 Infection and Their Importance in Understanding the Severity of COVID-19
title Changes in Glycolytic Pathway in SARS-COV 2 Infection and Their Importance in Understanding the Severity of COVID-19
spellingShingle Changes in Glycolytic Pathway in SARS-COV 2 Infection and Their Importance in Understanding the Severity of COVID-19
Santos, Adalberto Fernandes
COVID-19
glycolytic pathway
hyperglycolysis
oxidative phosphorylation
reactive oxygen species
Chemistry(all)
SDG 3 - Good Health and Well-being
title_short Changes in Glycolytic Pathway in SARS-COV 2 Infection and Their Importance in Understanding the Severity of COVID-19
title_full Changes in Glycolytic Pathway in SARS-COV 2 Infection and Their Importance in Understanding the Severity of COVID-19
title_fullStr Changes in Glycolytic Pathway in SARS-COV 2 Infection and Their Importance in Understanding the Severity of COVID-19
title_full_unstemmed Changes in Glycolytic Pathway in SARS-COV 2 Infection and Their Importance in Understanding the Severity of COVID-19
title_sort Changes in Glycolytic Pathway in SARS-COV 2 Infection and Their Importance in Understanding the Severity of COVID-19
author Santos, Adalberto Fernandes
author_facet Santos, Adalberto Fernandes
Povoa, Pedro
Paixão, Paulo
Mendonça, António
Taborda-Barata, Luís
author_role author
author2 Povoa, Pedro
Paixão, Paulo
Mendonça, António
Taborda-Barata, Luís
author2_role author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Comprehensive Health Research Centre (CHRC) - pólo NMS
RUN
dc.contributor.author.fl_str_mv Santos, Adalberto Fernandes
Povoa, Pedro
Paixão, Paulo
Mendonça, António
Taborda-Barata, Luís
dc.subject.por.fl_str_mv COVID-19
glycolytic pathway
hyperglycolysis
oxidative phosphorylation
reactive oxygen species
Chemistry(all)
SDG 3 - Good Health and Well-being
topic COVID-19
glycolytic pathway
hyperglycolysis
oxidative phosphorylation
reactive oxygen species
Chemistry(all)
SDG 3 - Good Health and Well-being
description Publisher Copyright: © Copyright © 2021 Santos, Póvoa, Paixão, Mendonça and Taborda-Barata.
publishDate 2021
dc.date.none.fl_str_mv 2021-10-22T03:43:14Z
2021-09-10
2021-09-10T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/126487
url http://hdl.handle.net/10362/126487
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2296-2646
PURE: 34203711
https://doi.org/10.3389/fchem.2021.685196
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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