Dependence of cell proliferation on the morphology of starch based scaffolds for tissue engineering

• Main Author: Chung, S.
• Publication Date: 2008
• Other Authors: Martins, A., Correlo, V. M., Oliveira, J. T., Marques, A. P., Neves, N. M., Mano, J. F., Sousa, R. A., Reis, R. L.
• Language: eng
• Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
• Download full: http://hdl.handle.net/1822/59209
• topic: Ciências Médicas::Biotecnologia Médica; Engenharia e Tecnologia::Biotecnologia Industrial; Science & Technology

[Excerpt] In tissue engineering (TE), several biological, mechanical and geometrical design constraints need to be addressed in order to create an adequate micro-environment for cells response. In this study, the correlation between architectural features of the scaffold construct and cellular behavior was investigated for a blend of starch and polycaprolactone (SPCL). The aim was to determine the effects of scaffold parameters on mechanical properties on cell seeding efficiency and proliferation of human osteoblast-like cells (SaOs-2) of scaffolds obtained via Rapid Prototyping (Bioplotter) and fiber bonding. For fiber bonding, a L8 design of experiment approach was used to produce different scaffold morphologies and properties by systematically varying processing parameters. [...]