GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression

Bibliographic Details
Main Author: Pinheiro, Céline
Publication Date: 2011
Other Authors: Sousa, Bárbara, Albergaria, André, Paredes, Joana, Dufloth, Rozany, Vieira, Daniella, Schmitt, Fernando C., Baltazar, Fátima
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/1822/17364
Summary: We thank Dr. Vitor Carneiro (pathologist from the Hospital do Divino Espírito Santo, Ponta Delgada, São Miguel, Azores), for his help in retrieving the breast cancer samples for this study.
id RCAP_714e2da13c1f8d19eb1eea76f0a6d185
oai_identifier_str oai:repositorium.sdum.uminho.pt:1822/17364
network_acronym_str RCAP
network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository_id_str https://opendoar.ac.uk/repository/7160
spelling GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpressionGLUT1CAIXMonocarboxylate transporters (MCTs)CD147/EMMPRINBreast carcinomaImmunohistochemistryScience & TechnologyWe thank Dr. Vitor Carneiro (pathologist from the Hospital do Divino Espírito Santo, Ponta Delgada, São Miguel, Azores), for his help in retrieving the breast cancer samples for this study.The goal of the present work was to evaluate the correlation of glucose transporter 1 (GLUT1) and carbonic anhydrase IX (CAIX) with the monocarboxylate transporters 1 (MCT1) and 4 (MCT4) and their chaperone, CD147, in breast cancer. The clinico-pathological value of GLUT1 and CAIX was also evaluated. For that, we analysed the immunohistochemical expression of GLUT1 and CAIX, in a large series of invasive breast carcinoma samples (n=124), previously characterized for MCT1, MCT4 and CD147 expression. GLUT1 expression was found in 46% of the cases (57/124), while CAIX was found in 18% of the cases (22/122). Importantly, both MCT1 and CD147, but not MCT4, were associated with GLUT1 and CAIX expression. Also, GLUT1 and CAIX correlated with each other. Concerning the clinico-pathological values, GLUT1 was associated with high grade tumours, basal-like subtype, absence of progesterone receptor, presence of vimentin and high proliferative index as measured by Ki-67. Additionally, CAIX was associated with large tumour size, high histological grade, basal-like subtype, absence of estrogen and progesterone receptors and presence of basal cytokeratins and vimentin expression. Finally, patients with CAIX positive tumours had a significantly shorter disease-free survival. The association between MCT1 and both GLUT1 and CAIX may result from hypoxia-mediated metabolic adaptations, which confer a glycolytic, acid-resistant and more aggressive phenotype to cancer cells.CP and AA received fellowships from the Portuguese Foundation for Science and Technology (FCT), refs. SFRH/BD/27465/2006 and SFRH/BD/15316/2005, respectively. This work was supported by the FCT grant ref. PTDC/SAU-FCF/104347/2008, under the scope of “Programa Operacional Temático Factores de Competitividade” (COMPETE) of “Quadro Comunitário de Apoio III” and co-financed by Fundo Comunitário Europeu FEDER.Consejería de Sanidad de la Comunidad Autónoma de MurciaSociedad Española de Histología e Ingeniería Tisular; Histology and HistopathologyUniversidade do MinhoPinheiro, CélineSousa, BárbaraAlbergaria, AndréParedes, JoanaDufloth, RozanyVieira, DaniellaSchmitt, Fernando C.Baltazar, Fátima2011-102011-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/17364eng0213-391121870331http://www.hh.um.es/2011/HH_26_10_2011.htminfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-11T07:34:31Zoai:repositorium.sdum.uminho.pt:1822/17364Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T16:31:51.251088Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression
title GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression
spellingShingle GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression
Pinheiro, Céline
GLUT1
CAIX
Monocarboxylate transporters (MCTs)
CD147/EMMPRIN
Breast carcinoma
Immunohistochemistry
Science & Technology
title_short GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression
title_full GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression
title_fullStr GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression
title_full_unstemmed GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression
title_sort GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression
author Pinheiro, Céline
author_facet Pinheiro, Céline
Sousa, Bárbara
Albergaria, André
Paredes, Joana
Dufloth, Rozany
Vieira, Daniella
Schmitt, Fernando C.
Baltazar, Fátima
author_role author
author2 Sousa, Bárbara
Albergaria, André
Paredes, Joana
Dufloth, Rozany
Vieira, Daniella
Schmitt, Fernando C.
Baltazar, Fátima
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Pinheiro, Céline
Sousa, Bárbara
Albergaria, André
Paredes, Joana
Dufloth, Rozany
Vieira, Daniella
Schmitt, Fernando C.
Baltazar, Fátima
dc.subject.por.fl_str_mv GLUT1
CAIX
Monocarboxylate transporters (MCTs)
CD147/EMMPRIN
Breast carcinoma
Immunohistochemistry
Science & Technology
topic GLUT1
CAIX
Monocarboxylate transporters (MCTs)
CD147/EMMPRIN
Breast carcinoma
Immunohistochemistry
Science & Technology
description We thank Dr. Vitor Carneiro (pathologist from the Hospital do Divino Espírito Santo, Ponta Delgada, São Miguel, Azores), for his help in retrieving the breast cancer samples for this study.
publishDate 2011
dc.date.none.fl_str_mv 2011-10
2011-10-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/17364
url http://hdl.handle.net/1822/17364
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0213-3911
21870331
http://www.hh.um.es/2011/HH_26_10_2011.htm
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Consejería de Sanidad de la Comunidad Autónoma de Murcia
Sociedad Española de Histología e Ingeniería Tisular; Histology and Histopathology
publisher.none.fl_str_mv Consejería de Sanidad de la Comunidad Autónoma de Murcia
Sociedad Española de Histología e Ingeniería Tisular; Histology and Histopathology
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833596003452715008

Similar Items