Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells

Bibliographic Details
Main Author: Nunes, Raquel J.
Publication Date: 2013
Other Authors: de Oliveira, Paula, Lages, Ana, Becker, Jörg D., Marcelino, Paulo, Barroso, Eduardo, Perdigoto, Rui, Kelly, Jeffery W., Quintas, Alexandre, Santos, Susana Constantino Rosa
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/50507
Summary: © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
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spelling Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cellsAngiogenesisEndothelial CellFamilial Amyloidotic PolyneuropathyGene ExpressionMicroarrayTransthyretinVascular Biology© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.Familial amyloidotic polyneuropathy (FAP) has a high prevalence in Portugal, and the most common form of hereditary amyloidosis is caused by an amyloidogenic variant of transthyretin (TTR) with a substitution of methionine for valine at position 30 (V30M). Until now, the available efficient therapy is liver transplantation, when performed in an early phase of the onset of the disease symptoms. However, transplanted FAP patients have a significantly higher incidence of early hepatic artery thrombosis compared with non-FAP transplanted patients. Because FAP was described as an independent risk factor for early hepatic artery thrombosis, more studies to understand the underlying mechanisms involved in this outcome are of the utmost importance. Knowing that the liver is the major site for TTR production, we investigated the biological effects of TTR proteins in the vasculature and on angiogenesis. In this study, we identified genes differentially expressed in endothelial cells exposed to the WT or V30M tetramer. We found that endothelial cells may acquire different molecular identities when exposed to these proteins, and consequently TTR could regulate angiogenesis. Moreover, we show that V30M decreases endothelial survival by inducing apoptosis, and it inhibits migration. These findings provide new knowledge that may have critical implications in the prevention of early hepatic artery thrombosis in FAP patients after liver transplantation.This work was supported by Fundação para a Ciencia e Tecnologia Grant PIC/IC/83062/2007. Supported by Fundação para a Ciencia e Tecnologia (FCT) Fellowship SFRH/BPD/43482/2008.ElsevierRepositório da Universidade de LisboaNunes, Raquel J.de Oliveira, PaulaLages, AnaBecker, Jörg D.Marcelino, PauloBarroso, EduardoPerdigoto, RuiKelly, Jeffery W.Quintas, AlexandreSantos, Susana Constantino Rosa2021-12-21T16:50:07Z20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50507engJ Biol Chem. 2013 Nov 1;288(44):31752-600021-925810.1074/jbc.M113.4698581083-351Xinfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:39:25Zoai:repositorio.ulisboa.pt:10451/50507Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:20:02.982724Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells
title Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells
spellingShingle Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells
Nunes, Raquel J.
Angiogenesis
Endothelial Cell
Familial Amyloidotic Polyneuropathy
Gene Expression
Microarray
Transthyretin
Vascular Biology
title_short Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells
title_full Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells
title_fullStr Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells
title_full_unstemmed Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells
title_sort Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells
author Nunes, Raquel J.
author_facet Nunes, Raquel J.
de Oliveira, Paula
Lages, Ana
Becker, Jörg D.
Marcelino, Paulo
Barroso, Eduardo
Perdigoto, Rui
Kelly, Jeffery W.
Quintas, Alexandre
Santos, Susana Constantino Rosa
author_role author
author2 de Oliveira, Paula
Lages, Ana
Becker, Jörg D.
Marcelino, Paulo
Barroso, Eduardo
Perdigoto, Rui
Kelly, Jeffery W.
Quintas, Alexandre
Santos, Susana Constantino Rosa
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Nunes, Raquel J.
de Oliveira, Paula
Lages, Ana
Becker, Jörg D.
Marcelino, Paulo
Barroso, Eduardo
Perdigoto, Rui
Kelly, Jeffery W.
Quintas, Alexandre
Santos, Susana Constantino Rosa
dc.subject.por.fl_str_mv Angiogenesis
Endothelial Cell
Familial Amyloidotic Polyneuropathy
Gene Expression
Microarray
Transthyretin
Vascular Biology
topic Angiogenesis
Endothelial Cell
Familial Amyloidotic Polyneuropathy
Gene Expression
Microarray
Transthyretin
Vascular Biology
description © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
publishDate 2013
dc.date.none.fl_str_mv 2013
2013-01-01T00:00:00Z
2021-12-21T16:50:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/50507
url http://hdl.handle.net/10451/50507
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Biol Chem. 2013 Nov 1;288(44):31752-60
0021-9258
10.1074/jbc.M113.469858
1083-351X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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