Microscale flow dynamics of red blood cells in microchannels: an experimental and numerical analysis

Detalhes bibliográficos
Autor(a) principal: Lima, Rui A.
Data de Publicação: 2011
Outros Autores: Fernandes, Carla S., Dias, Ricardo P., Ishikawa, Takuji, Imai, Yohsuke, Yamaguchi, Takami
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://hdl.handle.net/10198/10314
Resumo: The blood flow dynamics in microcirculation depends strongly on the microvascular networks composed with short irregular vessel segments which are linked by numerous bifurcations. This paper presents the application of a confocal micro-PTV system to track RBCs through a rectangular polydimethysiloxane (PDMS) microchannel with a bifurcation. By using a confocal micro-PTV system, we have measured the effect of bifurcation on the flow behaviour of both fluorescent particles diluted in pure water and RBCs in concentrated suspensions. After performing simulations with the commercial finite element software package POLYFLOW, some experimental results were compared with the numerical results and the limitations of these simulations were outlined.
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spelling Microscale flow dynamics of red blood cells in microchannels: an experimental and numerical analysisBlood flowBifurcationMicrochannelMicrovascular networksThe blood flow dynamics in microcirculation depends strongly on the microvascular networks composed with short irregular vessel segments which are linked by numerous bifurcations. This paper presents the application of a confocal micro-PTV system to track RBCs through a rectangular polydimethysiloxane (PDMS) microchannel with a bifurcation. By using a confocal micro-PTV system, we have measured the effect of bifurcation on the flow behaviour of both fluorescent particles diluted in pure water and RBCs in concentrated suspensions. After performing simulations with the commercial finite element software package POLYFLOW, some experimental results were compared with the numerical results and the limitations of these simulations were outlined.This study was supported in part by the following grants: Grant-in-Aid for Science and Technology (BII/UNI/0532/EME/2008, PTDC/SAU-BEB/108728/2008, PTDC/SAUBEB/ 105650/2008 and PTDC/EME-MFE/099109/2008) from the Science and Technology Foundation (FCT) and COMPETE, Portugal and Grant-in-Aid for Scientific Research (S) from the Japan Society for the Promotion of Science (JSPS; No.19100008). We also acknowledge the support from the 2007 Global COE Program “Global Nano-Biomedical Engineering Education and Research Network”. The authors would like also to thank Dr. C. Balsa for his valuable assistance and support for the MATLAB numerical calculations and Ms. B. Oliveira, Ms. D. Cidre and Mr. M. Lagoela for their valuable technical assistance in this research work.SpringerBiblioteca Digital do IPBLima, Rui A.Fernandes, Carla S.Dias, Ricardo P.Ishikawa, TakujiImai, YohsukeYamaguchi, Takami2014-09-04T14:46:49Z20112011-01-01T00:00:00Zconference objectinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10198/10314engLima, R.; Fernandes, Carla S.; Dias, Ricardo P.; Ishikawa, T.; Imai, Y.; Yamaguchi, T. (2011). Microscale flow dynamics of red blood cells in microchannels: an experimental and numerical analysis. In 2nd ECCOMAS Thematic Conference on Computational Vision andMedical Image processing, VIPimage 2009. Dordrecht: Springer. p. 297-309. ISBN 978-94-007-0010-9978-94-007-0010-9info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-02-25T12:01:23Zoai:bibliotecadigital.ipb.pt:10198/10314Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T11:26:00.750315Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Microscale flow dynamics of red blood cells in microchannels: an experimental and numerical analysis
title Microscale flow dynamics of red blood cells in microchannels: an experimental and numerical analysis
spellingShingle Microscale flow dynamics of red blood cells in microchannels: an experimental and numerical analysis
Lima, Rui A.
Blood flow
Bifurcation
Microchannel
Microvascular networks
title_short Microscale flow dynamics of red blood cells in microchannels: an experimental and numerical analysis
title_full Microscale flow dynamics of red blood cells in microchannels: an experimental and numerical analysis
title_fullStr Microscale flow dynamics of red blood cells in microchannels: an experimental and numerical analysis
title_full_unstemmed Microscale flow dynamics of red blood cells in microchannels: an experimental and numerical analysis
title_sort Microscale flow dynamics of red blood cells in microchannels: an experimental and numerical analysis
author Lima, Rui A.
author_facet Lima, Rui A.
Fernandes, Carla S.
Dias, Ricardo P.
Ishikawa, Takuji
Imai, Yohsuke
Yamaguchi, Takami
author_role author
author2 Fernandes, Carla S.
Dias, Ricardo P.
Ishikawa, Takuji
Imai, Yohsuke
Yamaguchi, Takami
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Biblioteca Digital do IPB
dc.contributor.author.fl_str_mv Lima, Rui A.
Fernandes, Carla S.
Dias, Ricardo P.
Ishikawa, Takuji
Imai, Yohsuke
Yamaguchi, Takami
dc.subject.por.fl_str_mv Blood flow
Bifurcation
Microchannel
Microvascular networks
topic Blood flow
Bifurcation
Microchannel
Microvascular networks
description The blood flow dynamics in microcirculation depends strongly on the microvascular networks composed with short irregular vessel segments which are linked by numerous bifurcations. This paper presents the application of a confocal micro-PTV system to track RBCs through a rectangular polydimethysiloxane (PDMS) microchannel with a bifurcation. By using a confocal micro-PTV system, we have measured the effect of bifurcation on the flow behaviour of both fluorescent particles diluted in pure water and RBCs in concentrated suspensions. After performing simulations with the commercial finite element software package POLYFLOW, some experimental results were compared with the numerical results and the limitations of these simulations were outlined.
publishDate 2011
dc.date.none.fl_str_mv 2011
2011-01-01T00:00:00Z
2014-09-04T14:46:49Z
dc.type.driver.fl_str_mv conference object
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10198/10314
url http://hdl.handle.net/10198/10314
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Lima, R.; Fernandes, Carla S.; Dias, Ricardo P.; Ishikawa, T.; Imai, Y.; Yamaguchi, T. (2011). Microscale flow dynamics of red blood cells in microchannels: an experimental and numerical analysis. In 2nd ECCOMAS Thematic Conference on Computational Vision andMedical Image processing, VIPimage 2009. Dordrecht: Springer. p. 297-309. ISBN 978-94-007-0010-9
978-94-007-0010-9
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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