Synthesis of phenolic compounds from virgin olive oil and their biological evaluation

Bibliographic Details
Main Author: Martins, B.T.
Publication Date: 2024
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/182542
Summary: "In recent years, investigating the bioactive compounds from natural sources, and their synthesis, has garnered significant attention due to their biological benefits. Among these, the phenolic compounds in extra virgin olive oil (EVOO) have been recognised for their diverse biological activities, including antioxidant, anti inflammatory and antiproliferative effects. This thesis delves into the synthesis, stability and biological evaluation of hydroxytyrosol (HT) and its derivatives, as well as the development of innovative synthetic strategies for the obtention of oleocanthal and oleacein, two other important phenolic compounds in EVOO. One of the main goals of this research was to develop efficient and scalable synthetic methods for HT and its derivatives, as detailed in Chapter 2. This chapter presents novel approaches for the regioselective synthesis of HT glucuronides and sulfates, overcoming challenges related to regioisomeric mixtures and paving the way for further biological studies."
id RCAP_6a63a4a16a580017d7f7b74ac621b691
oai_identifier_str oai:run.unl.pt:10362/182542
network_acronym_str RCAP
network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository_id_str https://opendoar.ac.uk/repository/7160
spelling Synthesis of phenolic compounds from virgin olive oil and their biological evaluationExtra Virgin Olive Oilbioactive compoundsphenolic compoundsasymmetric synthesisoleaceinaziridineshydroxytyrosololeocanthalDomínio/Área Científica::Ciências Naturais"In recent years, investigating the bioactive compounds from natural sources, and their synthesis, has garnered significant attention due to their biological benefits. Among these, the phenolic compounds in extra virgin olive oil (EVOO) have been recognised for their diverse biological activities, including antioxidant, anti inflammatory and antiproliferative effects. This thesis delves into the synthesis, stability and biological evaluation of hydroxytyrosol (HT) and its derivatives, as well as the development of innovative synthetic strategies for the obtention of oleocanthal and oleacein, two other important phenolic compounds in EVOO. One of the main goals of this research was to develop efficient and scalable synthetic methods for HT and its derivatives, as detailed in Chapter 2. This chapter presents novel approaches for the regioselective synthesis of HT glucuronides and sulfates, overcoming challenges related to regioisomeric mixtures and paving the way for further biological studies."Ventura, RitaRUNMartins, B.T.2025-03-202024-11-222025-11-30T00:00:00Z2025-03-20T00:00:00Zdoctoral thesisinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10362/182542TID:101818688enginfo:eu-repo/semantics/embargoedAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-04-28T01:34:03Zoai:run.unl.pt:10362/182542Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T06:33:30.878579Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Synthesis of phenolic compounds from virgin olive oil and their biological evaluation
title Synthesis of phenolic compounds from virgin olive oil and their biological evaluation
spellingShingle Synthesis of phenolic compounds from virgin olive oil and their biological evaluation
Martins, B.T.
Extra Virgin Olive Oil
bioactive compounds
phenolic compounds
asymmetric synthesis
oleacein
aziridines
hydroxytyrosol
oleocanthal
Domínio/Área Científica::Ciências Naturais
title_short Synthesis of phenolic compounds from virgin olive oil and their biological evaluation
title_full Synthesis of phenolic compounds from virgin olive oil and their biological evaluation
title_fullStr Synthesis of phenolic compounds from virgin olive oil and their biological evaluation
title_full_unstemmed Synthesis of phenolic compounds from virgin olive oil and their biological evaluation
title_sort Synthesis of phenolic compounds from virgin olive oil and their biological evaluation
author Martins, B.T.
author_facet Martins, B.T.
author_role author
dc.contributor.none.fl_str_mv Ventura, Rita
RUN
dc.contributor.author.fl_str_mv Martins, B.T.
dc.subject.por.fl_str_mv Extra Virgin Olive Oil
bioactive compounds
phenolic compounds
asymmetric synthesis
oleacein
aziridines
hydroxytyrosol
oleocanthal
Domínio/Área Científica::Ciências Naturais
topic Extra Virgin Olive Oil
bioactive compounds
phenolic compounds
asymmetric synthesis
oleacein
aziridines
hydroxytyrosol
oleocanthal
Domínio/Área Científica::Ciências Naturais
description "In recent years, investigating the bioactive compounds from natural sources, and their synthesis, has garnered significant attention due to their biological benefits. Among these, the phenolic compounds in extra virgin olive oil (EVOO) have been recognised for their diverse biological activities, including antioxidant, anti inflammatory and antiproliferative effects. This thesis delves into the synthesis, stability and biological evaluation of hydroxytyrosol (HT) and its derivatives, as well as the development of innovative synthetic strategies for the obtention of oleocanthal and oleacein, two other important phenolic compounds in EVOO. One of the main goals of this research was to develop efficient and scalable synthetic methods for HT and its derivatives, as detailed in Chapter 2. This chapter presents novel approaches for the regioselective synthesis of HT glucuronides and sulfates, overcoming challenges related to regioisomeric mixtures and paving the way for further biological studies."
publishDate 2024
dc.date.none.fl_str_mv 2024-11-22
2025-03-20
2025-11-30T00:00:00Z
2025-03-20T00:00:00Z
dc.type.driver.fl_str_mv doctoral thesis
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/182542
TID:101818688
url http://hdl.handle.net/10362/182542
identifier_str_mv TID:101818688
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833602717782638592

Similar Items