Development of barley and yeast β-glucan aerogels for drug delivery by supercritical fluids

Bibliographic Details
Main Author: Salgado, Marta
Publication Date: 2017
Other Authors: Santos, Filipa, Rodríguez-Rojo, Soraya, Reis, R. L., Duarte, Ana Rita C., Cocero, María José
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://hdl.handle.net/1822/51426
Summary: Polysaccharide aerogels are a good alternative as carriers for drug delivery, since they allow high loading of the active compounds in matrices that are non-toxic, biocompatible and from a renewable feedstock. In this work, barley and yeast β-glucans aerogels were produced by gelation in aqueous solution, followed by solvent exchange and drying with supercritical CO2. First, viscoelastic properties and melting profile of the hydrogels were determined. Then, the obtained aerogels were analyzed regarding morphology, mechanical properties and behavior in physiological fluid. Both in the hydrogels and in the aerogels, big differences were observed between barley and yeast β-glucans due to their different chain structure and gelation behavior. Finally, impregnation of acetylsalicylic acid was performed at the same time as the drying of the alcogels with supercritical CO2. The release profile of the drug in PBS was analyzed in order to determine the mechanism governing the release from the β-glucan matrix.
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spelling Development of barley and yeast β-glucan aerogels for drug delivery by supercritical fluidsAcetylsalicylic acidAerogelRheologySupercritical dryingSupercritical impregnationβ-Glucanbeta-glucanScience & TechnologyPolysaccharide aerogels are a good alternative as carriers for drug delivery, since they allow high loading of the active compounds in matrices that are non-toxic, biocompatible and from a renewable feedstock. In this work, barley and yeast β-glucans aerogels were produced by gelation in aqueous solution, followed by solvent exchange and drying with supercritical CO2. First, viscoelastic properties and melting profile of the hydrogels were determined. Then, the obtained aerogels were analyzed regarding morphology, mechanical properties and behavior in physiological fluid. Both in the hydrogels and in the aerogels, big differences were observed between barley and yeast β-glucans due to their different chain structure and gelation behavior. Finally, impregnation of acetylsalicylic acid was performed at the same time as the drying of the alcogels with supercritical CO2. The release profile of the drug in PBS was analyzed in order to determine the mechanism governing the release from the β-glucan matrix.Authors acknowledge Ministerio de Economía y Competitividad (MINECO) through project CTQ2013-44143-R and project PIP 063/ 147181 from Fundación General of the University of Valladolid for fi- nancial support. M. Salgado thanks to Ministerio de Educación, Ciencia y Deporte (MECD) for her FPU and mobility grants. S. Rodríguez-Rojo acknowledges to MINECO and UVa for her Juan de la Cierva fellowship (JCI-2012-14992). The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement number REGPOT-CT2012- 316331-POLARIS and from the project “Novel smart and biomimetic materials for innovative regenerative medicine approaches” RL1 − ABMR − NORTE-01-0124-FEDER-000016) co-financed by North Portugal Regional Operational Programme (ON.2–O Novo Norte), under the National Strategic Reference Framework (NSRF), through the European Regional Development Fund (ERDF).info:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoSalgado, MartaSantos, FilipaRodríguez-Rojo, SorayaReis, R. L.Duarte, Ana Rita C.Cocero, María José2017-11-022017-11-02T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/51426engSalgado M., Santos F., Rodríguez-Rojo S., Reis R. L., Duarte A. R. C., Cocero M. J. Development of barley and yeast β-glucan aerogels for drug delivery by supercritical fluids, Journal of CO₂ Utilization, Vol. 22, Issue -, pp. 262–269, doi:10.1016/j.jcou.2017.10.006, 20172212-982010.1016/j.jcou.2017.10.006https://www.sciencedirect.com/science/article/pii/S2212982017303190?via%3Dihubinfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-04-12T03:57:04Zoai:repositorium.sdum.uminho.pt:1822/51426Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T14:46:55.621715Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Development of barley and yeast β-glucan aerogels for drug delivery by supercritical fluids
title Development of barley and yeast β-glucan aerogels for drug delivery by supercritical fluids
spellingShingle Development of barley and yeast β-glucan aerogels for drug delivery by supercritical fluids
Salgado, Marta
Acetylsalicylic acid
Aerogel
Rheology
Supercritical drying
Supercritical impregnation
β-Glucan
beta-glucan
Science & Technology
title_short Development of barley and yeast β-glucan aerogels for drug delivery by supercritical fluids
title_full Development of barley and yeast β-glucan aerogels for drug delivery by supercritical fluids
title_fullStr Development of barley and yeast β-glucan aerogels for drug delivery by supercritical fluids
title_full_unstemmed Development of barley and yeast β-glucan aerogels for drug delivery by supercritical fluids
title_sort Development of barley and yeast β-glucan aerogels for drug delivery by supercritical fluids
author Salgado, Marta
author_facet Salgado, Marta
Santos, Filipa
Rodríguez-Rojo, Soraya
Reis, R. L.
Duarte, Ana Rita C.
Cocero, María José
author_role author
author2 Santos, Filipa
Rodríguez-Rojo, Soraya
Reis, R. L.
Duarte, Ana Rita C.
Cocero, María José
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Salgado, Marta
Santos, Filipa
Rodríguez-Rojo, Soraya
Reis, R. L.
Duarte, Ana Rita C.
Cocero, María José
dc.subject.por.fl_str_mv Acetylsalicylic acid
Aerogel
Rheology
Supercritical drying
Supercritical impregnation
β-Glucan
beta-glucan
Science & Technology
topic Acetylsalicylic acid
Aerogel
Rheology
Supercritical drying
Supercritical impregnation
β-Glucan
beta-glucan
Science & Technology
description Polysaccharide aerogels are a good alternative as carriers for drug delivery, since they allow high loading of the active compounds in matrices that are non-toxic, biocompatible and from a renewable feedstock. In this work, barley and yeast β-glucans aerogels were produced by gelation in aqueous solution, followed by solvent exchange and drying with supercritical CO2. First, viscoelastic properties and melting profile of the hydrogels were determined. Then, the obtained aerogels were analyzed regarding morphology, mechanical properties and behavior in physiological fluid. Both in the hydrogels and in the aerogels, big differences were observed between barley and yeast β-glucans due to their different chain structure and gelation behavior. Finally, impregnation of acetylsalicylic acid was performed at the same time as the drying of the alcogels with supercritical CO2. The release profile of the drug in PBS was analyzed in order to determine the mechanism governing the release from the β-glucan matrix.
publishDate 2017
dc.date.none.fl_str_mv 2017-11-02
2017-11-02T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/51426
url https://hdl.handle.net/1822/51426
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Salgado M., Santos F., Rodríguez-Rojo S., Reis R. L., Duarte A. R. C., Cocero M. J. Development of barley and yeast β-glucan aerogels for drug delivery by supercritical fluids, Journal of CO₂ Utilization, Vol. 22, Issue -, pp. 262–269, doi:10.1016/j.jcou.2017.10.006, 2017
2212-9820
10.1016/j.jcou.2017.10.006
https://www.sciencedirect.com/science/article/pii/S2212982017303190?via%3Dihub
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833594881821376512

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