Increased frequency of circulating CCR5+ CD4+ T cells in human immunodeficiency virus type 2 infection

Bibliographic Details
Main Author: Soares, R.
Publication Date: 2006
Other Authors: Foxall, R., Albuquerque, A., Cortesão, C., Garcia, M., Victorino, R. M., Sousa, A. E.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/15880
Summary: © 2006, American Society for Microbiology. All Rights Reserved.
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spelling Increased frequency of circulating CCR5+ CD4+ T cells in human immunodeficiency virus type 2 infection© 2006, American Society for Microbiology. All Rights Reserved.CCR5 expression determines susceptibility to infection, cell tropism, and the rate of human immunodeficiency virus type 1 (HIV-1) disease progression. CCR5 is also considered the major HIV-2 coreceptor in vivo, in spite of broad coreceptor use in vitro. Here we report a significantly increased proportion of memory-effector CD4 T cells expressing CCR5 in HIV-2-infected patients correlating with CD4 depletion. Moreover, HIV-2 proviral DNA was essentially restricted to memory-effector CD4, suggesting that this is the main target for HIV-2. Similar levels of proviral DNA were found in the two infection categories. Thus, the reduced viremia and slow rate of CD4 decline that characterize HIV-2 infection seem to be unrelated to coreceptor availability.This work was supported by grants from Fundação para a Ciência e a Tecnologia (FCT) and Comissão Nacional de Luta Contra a SIDA to A.E.S. R.S., R.F., and C.C. received scholarships from FCT.American Society for MicrobiologyRepositório da Universidade de LisboaSoares, R.Foxall, R.Albuquerque, A.Cortesão, C.Garcia, M.Victorino, R. M.Sousa, A. E.2015-02-03T16:46:43Z20062006-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/15880engJournal of Virology, Dec. 2006, Vol. 80, No. 24, p. 12425–124290022-538Xhttp://dx.doi.org/ 10.1128/JVI.01557-06info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T13:16:21Zoai:repositorio.ulisboa.pt:10451/15880Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T02:39:33.734216Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Increased frequency of circulating CCR5+ CD4+ T cells in human immunodeficiency virus type 2 infection
title Increased frequency of circulating CCR5+ CD4+ T cells in human immunodeficiency virus type 2 infection
spellingShingle Increased frequency of circulating CCR5+ CD4+ T cells in human immunodeficiency virus type 2 infection
Soares, R.
title_short Increased frequency of circulating CCR5+ CD4+ T cells in human immunodeficiency virus type 2 infection
title_full Increased frequency of circulating CCR5+ CD4+ T cells in human immunodeficiency virus type 2 infection
title_fullStr Increased frequency of circulating CCR5+ CD4+ T cells in human immunodeficiency virus type 2 infection
title_full_unstemmed Increased frequency of circulating CCR5+ CD4+ T cells in human immunodeficiency virus type 2 infection
title_sort Increased frequency of circulating CCR5+ CD4+ T cells in human immunodeficiency virus type 2 infection
author Soares, R.
author_facet Soares, R.
Foxall, R.
Albuquerque, A.
Cortesão, C.
Garcia, M.
Victorino, R. M.
Sousa, A. E.
author_role author
author2 Foxall, R.
Albuquerque, A.
Cortesão, C.
Garcia, M.
Victorino, R. M.
Sousa, A. E.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Soares, R.
Foxall, R.
Albuquerque, A.
Cortesão, C.
Garcia, M.
Victorino, R. M.
Sousa, A. E.
description © 2006, American Society for Microbiology. All Rights Reserved.
publishDate 2006
dc.date.none.fl_str_mv 2006
2006-01-01T00:00:00Z
2015-02-03T16:46:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/15880
url http://hdl.handle.net/10451/15880
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Virology, Dec. 2006, Vol. 80, No. 24, p. 12425–12429
0022-538X
http://dx.doi.org/ 10.1128/JVI.01557-06
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833601443613900800

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