Methicillin-Resistant Staphylococcus aureus
| Main Author: | |
|---|---|
| Publication Date: | 2025 |
| Other Authors: | , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Download full: | http://hdl.handle.net/10362/178780 |
Summary: | Publisher Copyright: © 2025 by the authors. |
| id |
RCAP_65fd1e209c868f405ffe41902fef9c46 |
|---|---|
| oai_identifier_str |
oai:run.unl.pt:10362/178780 |
| network_acronym_str |
RCAP |
| network_name_str |
Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| repository_id_str |
https://opendoar.ac.uk/repository/7160 |
| spelling |
Methicillin-Resistant Staphylococcus aureusThe Shifting Landscape in the United Arab Emiratesantimicrobial resistancegenotypingmicroarrayMRSAStaphylococcus aureusMicrobiologyBiochemistryPharmacology, Toxicology and Pharmaceutics(all)Microbiology (medical)Infectious DiseasesPharmacology (medical)SDG 3 - Good Health and Well-beingPublisher Copyright: © 2025 by the authors.Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a significant burden globally, particularly in the Arabian Gulf region. The United Arab Emirates (UAE) has experienced rising MRSA prevalence, with increasing diversity in the clonal complexes (CCs) identified. The COVID-19 pandemic, with its increased hospitalization rates and antibiotic use, may have further influenced MRSA’s genetic evolution and epidemiology in the country. Methods: To investigate this influence, genomic profiling of 310 MRSA clinical isolates collected between February and November 2022 was performed using a DNA microarray-based assay. Results: Isolates were assigned to 22 clonal complexes and 72 distinct strain assignments. The predominant clonal complexes were CC5, CC6, CC361, CC22, CC1, and CC8. Community-acquired MRSA lineages were dominant, with only one healthcare-associated MRSA lineage isolate identified. Upward trends of CC1153 were observed along with rare CCs, such as CC121-MRSA and CC7-MRSA, with the latter being reported for the first time in the Arabian Gulf region. The presence of pandemic strains USA300 CC8-MRSA-[IVa + ACME1] and CC8-MRSA-IV strains were also observed, including variants lacking Panton–Valentine leukocidin (pvl) genes and missing tst1 or enterotoxin genes. The PVL-negative CC772-MRSA-V/VT was identified, representing its first report in the UAE. A novel variant, CC361-MRSA-IV (tst1+/PVL+), was identified. Pvl genes were observed in 36% of the isolates, primarily from skin and soft tissue infections, while fusC (SCC-borne fusidic acid resistance) was identified in 13% of the isolates. Conclusions: The findings highlight the ongoing evolution of MRSA in the UAE, with the persistence and emergence of diverse and rare clonal complexes, driving the need for continuous genomic surveillance.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centre for Toxicogenomics and Human Health (ToxOmics)RUNBoucherabine, SyrineNassar, RaniaMohamed, LobnaHabous, MayaNabi, AnjuHusain, Riyaz AmiraliAlfaresi, MubarakOommen, SeemaKhansaheb, Hamda HassanAl Sharhan, MouzaCeliloglu, HandanRaja, Mubarak HussainAbdelkarim, EmanAli, NishiTausif, SalmanOlowoyeye, VictorySoares, Nelson CruzHachim, MahmoodMoradigaravand, DaneshEverett, DeanMueller, ElkeMonecke, StefanEhricht, RalfSenok, Abiola2025-02-10T21:19:55Z2025-012025-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/178780eng2079-6382PURE: 109216665https://doi.org/10.3390/antibiotics14010024info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-02-24T01:42:13Zoai:run.unl.pt:10362/178780Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T20:39:31.925191Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
Methicillin-Resistant Staphylococcus aureus The Shifting Landscape in the United Arab Emirates |
| title |
Methicillin-Resistant Staphylococcus aureus |
| spellingShingle |
Methicillin-Resistant Staphylococcus aureus Boucherabine, Syrine antimicrobial resistance genotyping microarray MRSA Staphylococcus aureus Microbiology Biochemistry Pharmacology, Toxicology and Pharmaceutics(all) Microbiology (medical) Infectious Diseases Pharmacology (medical) SDG 3 - Good Health and Well-being |
| title_short |
Methicillin-Resistant Staphylococcus aureus |
| title_full |
Methicillin-Resistant Staphylococcus aureus |
| title_fullStr |
Methicillin-Resistant Staphylococcus aureus |
| title_full_unstemmed |
Methicillin-Resistant Staphylococcus aureus |
| title_sort |
Methicillin-Resistant Staphylococcus aureus |
| author |
Boucherabine, Syrine |
| author_facet |
Boucherabine, Syrine Nassar, Rania Mohamed, Lobna Habous, Maya Nabi, Anju Husain, Riyaz Amirali Alfaresi, Mubarak Oommen, Seema Khansaheb, Hamda Hassan Al Sharhan, Mouza Celiloglu, Handan Raja, Mubarak Hussain Abdelkarim, Eman Ali, Nishi Tausif, Salman Olowoyeye, Victory Soares, Nelson Cruz Hachim, Mahmood Moradigaravand, Danesh Everett, Dean Mueller, Elke Monecke, Stefan Ehricht, Ralf Senok, Abiola |
| author_role |
author |
| author2 |
Nassar, Rania Mohamed, Lobna Habous, Maya Nabi, Anju Husain, Riyaz Amirali Alfaresi, Mubarak Oommen, Seema Khansaheb, Hamda Hassan Al Sharhan, Mouza Celiloglu, Handan Raja, Mubarak Hussain Abdelkarim, Eman Ali, Nishi Tausif, Salman Olowoyeye, Victory Soares, Nelson Cruz Hachim, Mahmood Moradigaravand, Danesh Everett, Dean Mueller, Elke Monecke, Stefan Ehricht, Ralf Senok, Abiola |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Centre for Toxicogenomics and Human Health (ToxOmics) RUN |
| dc.contributor.author.fl_str_mv |
Boucherabine, Syrine Nassar, Rania Mohamed, Lobna Habous, Maya Nabi, Anju Husain, Riyaz Amirali Alfaresi, Mubarak Oommen, Seema Khansaheb, Hamda Hassan Al Sharhan, Mouza Celiloglu, Handan Raja, Mubarak Hussain Abdelkarim, Eman Ali, Nishi Tausif, Salman Olowoyeye, Victory Soares, Nelson Cruz Hachim, Mahmood Moradigaravand, Danesh Everett, Dean Mueller, Elke Monecke, Stefan Ehricht, Ralf Senok, Abiola |
| dc.subject.por.fl_str_mv |
antimicrobial resistance genotyping microarray MRSA Staphylococcus aureus Microbiology Biochemistry Pharmacology, Toxicology and Pharmaceutics(all) Microbiology (medical) Infectious Diseases Pharmacology (medical) SDG 3 - Good Health and Well-being |
| topic |
antimicrobial resistance genotyping microarray MRSA Staphylococcus aureus Microbiology Biochemistry Pharmacology, Toxicology and Pharmaceutics(all) Microbiology (medical) Infectious Diseases Pharmacology (medical) SDG 3 - Good Health and Well-being |
| description |
Publisher Copyright: © 2025 by the authors. |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2025-02-10T21:19:55Z 2025-01 2025-01-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/178780 |
| url |
http://hdl.handle.net/10362/178780 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
2079-6382 PURE: 109216665 https://doi.org/10.3390/antibiotics14010024 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.source.none.fl_str_mv |
reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia instacron:RCAAP |
| instname_str |
FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia |
| instacron_str |
RCAAP |
| institution |
RCAAP |
| reponame_str |
Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| collection |
Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| repository.name.fl_str_mv |
Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia |
| repository.mail.fl_str_mv |
info@rcaap.pt |
| _version_ |
1833598778458767360 |